Results 71 to 80 of about 56,183 (304)

HMGB1/TLR4 Signaling Affects Regulatory T Cells in Acute Lung Injury

Journal of Inflammation Research, 2021
Min Zhou,1,* Yadi Zhang,2,* Rui Tang,1 Haiyan Liu,1 Min Du,1 Zhi Gao,1 Zongshu Ji,1 Haoshu Fang3 1Neurocritical Care Unit, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei,
Zhou M, Zhang Y, Tang R, Liu H, Du M, Gao Z, Ji Z, Fang H   +7 more
doaj  

HMGB1-dependent and -independent autophagy [PDF]

Autophagy, 2014
HMGB1 (high mobility group box 1) is a multifunctional, ubiquitous protein located inside and outside cells that plays a critical role in various physiological and pathological processes including cell development, differentiation, inflammation, immunity, metastasis, metabolism, and death. Increasing evidence demonstrates that HMGB1-dependent autophagy
Sun, Xiaofang, Tang, Daolin
openaire   +2 more sources

Multifunctional Neutrophil Nanovesicles Induce Remodeling of Tumor Immune Microenvironment and Synergistic Multimodal Tumor Therapy

Advanced Functional Materials, EarlyView.
Schematic illustration of the engineered RN@FDT for multimodal tumor therapy. a) Fabrication of FD&DOX/TFA‐loaded RGD‐NNV (RN@FDT) and the light‐triggered disassemble of RN@FDT. b) After internalized by tumor cells, RN@FDT are disintegrated under NIR‐II laser irradiation to boost PTT and induce cell apoptosis.
Jiahui Zhang, Cheng Ji, Xin‐Jian Fang, Yu Qian, Jiayuan Shi, Wenhui Liu, Baiyuan Fan, Yuan Zhong, Jiayi Wang, Dan Yu, Maoye Wang, Min Fu, Xiaoxin Zhang, Runbi Ji, Hélder A. Santos, Hongbo Zhang, Xu Zhang   +16 more
wiley   +1 more source

High-mobility group chromosomal box protein 1 (HMGB1) mRNA is predominantly upregulated in areas of tissue destruction

, 2011
Copyright information:Taken from "Morphological characterization of intra-articular HMGB1 expression during the course of collagen-induced arthritis"http://arthritis-research.com/content/9/2/R35Arthritis Research & Therapy 2007;9(2):R35-R35.Published ...
Riikka Söderling (32046), Helena Erlandsson Harris (32049), Karin Palmblad (32044), Ann-Charlotte Aveberger (32047), Erik Sundberg (18849), Ulf Andersson (32048), Margarita Diez (32045)   +6 more
core   +1 more source

Nuclear Pore Mechanotransduction in Oncology: A Structural Axis of Vulnerability for Targeted Intervention

Advanced Materials, EarlyView.
Cancer‐associated NPC remodeling creates a high‐flux, low‐stringency nuclear state that supports malignant adaptation but increases mechanical fragility. Targeting the FG‐barrier or NPC scaffold may drive mechanostat failure, envelope rupture, DNA damage, and loss of nuclear integrity.
Sílvio Terra Stefanello, Caren Rigon Mizdal, Aline Franzen da Silva, Yun Qian, Wei‐En Yuan, Victor Shahin   +5 more
wiley   +1 more source

A substantial portion of cells expressing cytoplasmic high-mobility group chromosomal box protein 1 (HMGB1) are also ED1-positive

, 2011
Copyright information:Taken from "Morphological characterization of intra-articular HMGB1 expression during the course of collagen-induced arthritis"http://arthritis-research.com/content/9/2/R35Arthritis Research & Therapy 2007;9(2):R35-R35.Published ...
Riikka Söderling (32046), Helena Erlandsson Harris (32049), Karin Palmblad (32044), Ann-Charlotte Aveberger (32047), Erik Sundberg (18849), Ulf Andersson (32048), Margarita Diez (32045)   +6 more
core   +1 more source

High mobility group box 1 attenuates aortic stenosis by modulating macrophages to reduce valvular calcification

Polish Journal of Pathology
Our previous study demonstrated that HMGB1 may suppress M1 macrophage polarisation and mitigate the progression of calcific aortic valve disease (CAVD).
Dong Zhao, Yun Zhao, Li-Na Luan
doaj   +1 more source

CD9+ B Cells Induce T Follicular Helper Cell Apoptosis to Regulate Germinal Center Regression

Advanced Science, EarlyView.
A unique subset of CD9+ B cells regulates germinal center B (GC‐B) cell regression by inducing T follicular helper (Tfh) cell apoptosis through multiple signaling pathways, such as ALCAM‐CD6. FOXP1 plays a key role in GC‐B cell differentiation. These findings clarify mechanisms of GC degeneration and termination and offer potential targets for adenoid ...
Wenjing Liao, Lijuan Song, Meiqian Xu, Tianhao Liang, Yixuan Chen, Gui Chen, Zaihuan Lin, Huakang Du, Guofei Feng, Zhiming Feng, Qi Zhang, Fan Pan, Saixuan Yang, Xinyin Zhang, Wenxu Peng, Tianlong Li, Zhuoshen Lin, Yabang Chen, Jiayi Liu, Baoxin Peng, Yan Liu, Xing Niu, Ting Li, Chengyu Huang, Ke Mo, Jianlei Xie, Yu Zou, Xiaowen Zhang   +27 more
wiley   +1 more source

Neutrophil extracellular traps mediate the crosstalk between glioma progression and the tumor microenvironment via the HMGB1/RAGE/IL-8 axis

Cancer Biology & Medicine, 2020
Objective: Neutrophil extracellular traps (NETs) produced by tumor-infiltrating neutrophils (TINs) are associated with poor prognosis in patients with several types of cancer.
Caijun Zha, Xiangqi Meng, Lulu Li, Shan Mi, Da Qian, Ziwei Li, Pengfei Wu, Shaoshan Hu, Shihong Zhao, Jinquan Cai, Yanhong Liu   +10 more
doaj   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source