Results 61 to 70 of about 51,717 (306)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

HMGB1-MVs initiate mineralization both in vitro and in vivo.

open access: yes, 2016
(A) Control-MVs or HMGB1-MVs from RAW264.7 cells initiated mineralization in type I collagen-coated dishes was determined by Alizarin Red staining and stains were eluted and measured at 405 nm.
Jun-Jie Bei (3165936)   +8 more
core   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

open access: yesFEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa   +2 more
wiley   +1 more source

Long Non-Coding RNA PITPNA-AS1 Accelerates the Progression of Colorectal Cancer Through miR-129-5p/HMGB1 Axis

open access: yesCancer Management and Research, 2020
Chuanping Yuan, Ling Yang Department of Oncology, The Xinyu People’s Hospital, Xinyu, Jiangxi 338000, People’s Republic of ChinaCorrespondence: Ling YangDepartment of Oncology, The Xinyu People’s Hospital, No.369 Xinxin North Road ...
Yuan C, Yang L
doaj  

High-mobility group chromosomal box protein 1 (HMGB1) mRNA is predominantly upregulated in areas of tissue destruction

open access: yes, 2011
Copyright information:Taken from "Morphological characterization of intra-articular HMGB1 expression during the course of collagen-induced arthritis"http://arthritis-research.com/content/9/2/R35Arthritis Research & Therapy 2007;9(2):R35-R35.Published ...
Riikka Söderling (32046)   +6 more
core   +1 more source

Pull‐and‐Push Nanotherapeutic Hydrogels: Scavenging Inflammatory Triggers While Driving Tissue Regeneration in Burn Wounds

open access: yesAdvanced Functional Materials, EarlyView.
A nanounit‐assembled hydrogel employing a “pull‐and‐push” strategy simultaneously scavenges pro‐inflammatory cell‐free DNA (cfDNA) and delivers regenerative therapeutics in response to burn‐induced hyperthermia. By repolarizing macrophages and promoting angiogenesis, this multifunctional platform accelerates burn wound healing, offering a blueprint for
Han‐Sem Kim   +9 more
wiley   +1 more source

CircCFL1/MiR-107 Axis Targeting HMGB1 Promotes the Malignant Progression of Diffuse Large B-Cell Lymphoma Tumors

open access: yesCancer Management and Research, 2020
Xiaowei Chen,1,* Xiaobin Xie,2,* Wei Zhou1 1Department of Hematology, Guangzhou First People’s Hospital, South China University of Technology, Guangzhou 510080, Guangdong, People’s Republic of China; 2Department of Pathology, School of Basic ...
Chen X, Xie X, Zhou W
doaj  

A substantial portion of cells expressing cytoplasmic high-mobility group chromosomal box protein 1 (HMGB1) are also ED1-positive

open access: yes, 2011
Copyright information:Taken from "Morphological characterization of intra-articular HMGB1 expression during the course of collagen-induced arthritis"http://arthritis-research.com/content/9/2/R35Arthritis Research & Therapy 2007;9(2):R35-R35.Published ...
Riikka Söderling (32046)   +6 more
core   +1 more source

HMGB1 in severe soft tissue infections caused by Streptococcus pyogenes [PDF]

open access: yes, 2014
Extracellular High Mobility Group Box 1 (HMGB1) has been associated with acute and chronic inflammatory conditions. However, little is known about HMGB1 in necrotizing bacterial infections.
Carl-Johan Treutiger   +25 more
core   +1 more source

Cold Atmospheric Plasma‐Activated Decellularized Extracellular Matrix Gel as a Tumor‐Infiltrating Immunoactivation Platform for Post‐Surgical Cancer Immunotherapy

open access: yesAdvanced Materials, EarlyView.
An injectable cold atmospheric plasma‐activated decellularized tumor extracellular matrix hydrogel is introduced as a post‐surgical immunoactivation platform. The engineered gel attracts residual tumor cells and induces immunogenic cell death, reshaping the tumor microenvironment and eliciting systemic antitumor immunity. In combination with checkpoint
Tianxu Fang   +5 more
wiley   +1 more source

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