Results 61 to 70 of about 56,183 (304)
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
, 2011 Copyright information:Taken from "Morphological characterization of intra-articular HMGB1 expression during the course of collagen-induced arthritis"http://arthritis-research.com/content/9/2/R35Arthritis Research & Therapy 2007;9(2):R35-R35.Published ...
Riikka Söderling (32046) +6 more
core +1 more source
Cancer Management and Research, 2020 Xiaowei Chen,1,* Xiaobin Xie,2,* Wei Zhou1 1Department of Hematology, Guangzhou First People’s Hospital, South China University of Technology, Guangzhou 510080, Guangdong, People’s Republic of China; 2Department of Pathology, School of Basic ...
Chen X, Xie X, Zhou W
doaj
JACC: Basic to Translational Science, 2019 [Figure: see text]
Raucci, Angela, Capogrossi, Maurizio C.
openaire +2 more sources
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
HMGB1-MVs initiate mineralization both in vitro and in vivo.
, 2016 (A) Control-MVs or HMGB1-MVs from RAW264.7 cells initiated mineralization in type I collagen-coated dishes was determined by Alizarin Red staining and stains were eluted and measured at 405 nm.
Jun-Jie Bei (3165936) +8 more
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand +5 more
wiley +1 more source
High-mobility group box protein 1 (HMGB1) expression in collagen-induced arthritis
, 2011 The presence of cells expressing HMGB1 in the invading pannus of collagen-induced arthritis is shown. In this experiment, the section was stained for HMGB1 using affinity-purified polyclonal rabbit anti-HMGB1 antibodies (BD Pharmingen, San Diego, CA, USA)
David S Pisetsky (23495) +2 more
core +1 more source
Frontiers in Bioscience-LandmarkBackground: Macrophage polarization is involved in the development of ulcerative colitis (UC). This study investigated the mechanism by which high mobility group box-1 protein (HMGB1) regulates macrophage polarization through metabolic
Fenfen Wang +5 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian +6 more
wiley +1 more source