Results 1 to 10 of about 41,603 (119)

The Comprehensive Role of High Mobility Group Box 1 (HMGB1) Protein in Different Tumors: A Pan-Cancer Analysis [PDF]

Journal of Inflammation Research, 2023
Hui Guan,1 Ming Zhong,1 Kongyang Ma,2 Chun Tang,1 Xiaohua Wang,1 Muzi Ouyang,3 Rencai Qin,2 Jiasi Chen,1 Enyi Zhu,1 Ting Zhu,1 Yongping Lu,1 Yu Liu,1 Chengzi Tian,4 Zhihua Zheng1 1Department of Nephrology, Center of Kidney and Urology, The Seventh ...
Guan H, Zhong M, Ma K, Tang C, Wang X, Ouyang M, Qin R, Chen J, Zhu E, Zhu T, Lu Y, Liu Y, Tian C, Zheng Z   +13 more
doaj   +2 more sources

Adenovirus protein VII binds the A-box of HMGB1 to repress interferon responses.

PLoS Pathogens, 2023
Viruses hijack host proteins to promote infection and dampen host defenses. Adenovirus encodes the multifunctional protein VII that serves both to compact viral genomes inside the virion and disrupt host chromatin.
Edward A Arnold, Robin J Kaai, Katie Leung, Mia R Brinkley, Laurel E Kelnhofer-Millevolte, Monica S Guo, Daphne C Avgousti   +6 more
doaj   +1 more source

Reactive oxygen species induce Cys106-mediated anti-parallel HMGB1 dimerization that protects against DNA damage

Redox Biology, 2021
Oxidative stress can induce covalent disulfide bond formation between protein-protein thiol groups and generate hydroxyl free radicals that damage DNA. HMGB1 is a DNA chaperone and damage-associated molecular pattern molecule.
Man Sup Kwak, Woo Joong Rhee, Yong Joon Lee, Hee Sue Kim, Young Hun Kim, Min Kyung Kwon, Jeon-Soo Shin   +6 more
doaj   +1 more source

β-catenin has potential effects on the expression, subcellular localization, and release of high mobility group box 1 during bovine herpesvirus 1 productive infection in MDBK cell culture

Virulence, 2021
High mobility group box 1 (HMGB1), a ubiquitous DNA-binding protein, can be released into extracellular space and function as a strong proinflammatory cytokine, which plays critical roles in the pathogenesis of various inflammatory diseases.
Wenqing Fan, Weifeng Yuan, Xiuyan Ding, Liqian Zhu   +3 more
doaj   +1 more source

Reappraisal of oxidized HMGB1 as a mediator and biomarker

Future Science OA, 2022
HMGB1 is a dual-function protein that acts as a chromatin-binding protein and as a danger-associated molecular pattern (DAMP) when released from activated immune cells or injured tissue.
Ross Pirnie, Kevin P Gillespie, Clementina Mesaros, Ian A Blair   +3 more
doaj   +1 more source

Histone H1 Differentially Inhibits DNA Bending by Reduced and Oxidized HMGB1 Protein. [PDF]

PLoS ONE, 2015
HMGB1 protein and linker histone H1 have overlapping binding sites in the nucleosome. HMGB1 has been implicated in many DNA-dependent processes in chromatin involving binding of specific proteins, including transcription factors, to DNA sites pre-bent by
Michal Štros, Eva Polanská, Martin Kučírek, Šárka Pospíšilová   +3 more
doaj   +1 more source

HMGB1 Translocation in Neurons after Ischemic Insult: Subcellular Localization in Mitochondria and Peroxisomes

Cells, 2020
High mobility group box-1 (HMGB1), a nonhistone chromatin DNA-binding protein, is released from neurons into the extracellular space under ischemic, hemorrhagic, and traumatic insults. However, the details of the time-dependent translocation of HMGB1 and
Dengli Wang, Keyue Liu, Yusuke Fukuyasu, Kiyoshi Teshigawara, Li Fu, Hidenori Wake, Aiji Ohtsuka, Masahiro Nishibori   +7 more
doaj   +1 more source

Elevated HMGB1 promotes the malignant progression and contributes to cisplatin resistance of non-small cell lung cancer

Hereditas, 2023
Background HMGB1 (high mobility group box B-1) exhibits crucial role in tumor genesis and development, including lung cancer. Whereas, more HMGB1-related details in non-small cell lung cancer (NSCLC) are still largely unclear.
Ying Ma, Qin Feng, Bateer Han, Rong Yu, Zhiyong Jin   +4 more
doaj   +1 more source

The Effect and Regulatory Mechanism of High Mobility Group Box-1 Protein on Immune Cells in Inflammatory Diseases

Cells, 2021
High mobility group box-1 protein (HMGB1), a member of the high mobility group protein superfamily, is an abundant and ubiquitously expressed nuclear protein.
Yun Ge, Man Huang, Yong-ming Yao
doaj   +1 more source

Binding of histone H1 to DNA is differentially modulated by redox state of HMGB1. [PDF]

PLoS ONE, 2014
HMGB1 is an architectural protein in chromatin, acting also as a signaling molecule outside the cell. Recent reports from several laboratories provided evidence that a number of both the intracellular and extracellular functions of HMGB1 may depend on ...
Eva Polanská, Šárka Pospíšilová, Michal Štros   +2 more
doaj   +1 more source