Results 1 to 10 of about 45,099 (293)
Metabolic Syndrome and Autophagy: Focus on HMGB1 Protein. [PDF]
Front Cell Dev Biol, 2021 Metabolic syndrome (MetS) affects the population worldwide and results from several factors such as genetic background, environment and lifestyle. In recent years, an interplay among autophagy, metabolism, and metabolic disorders has become apparent.
Frisardi V, Matrone C, Street ME.
europepmc +10 more sources
Insights into telomeric G-quadruplex DNA recognition by HMGB1 protein. [PDF]
Nucleic Acids Res, 2019 Abstract HMGB1 is a ubiquitous non-histone protein, which biological effects depend on its expression and subcellular location. Inside the nucleus, HMGB1 is engaged in many DNA events such as DNA repair, transcription and telomere maintenance.
Amato J +13 more
europepmc +7 more sources
Functional Diversity of Non-Histone Chromosomal Protein HmgB1 [PDF]
International Journal of Molecular Sciences, 2020 The functioning of DNA in the cell nucleus is ensured by a multitude of proteins, whose interactions with DNA as well as with other proteins lead to the formation of a complicated, organized, and quite dynamic system known as chromatin. This review is devoted to the description of properties and structure of the progenitors of the most abundant non ...
Alexander Polyanichko +2 more
exaly +5 more sources
HMGB1 protein as a novel target for cancer. [PDF]
Toxicol Rep, 2019 Highly conserved nuclear protein High Mobility Group Box1 (HMGB1) present in mammals has functionality as an immuno-modulator in the form of cytokine molecule, as a nuclear factor to regulate these molecules and DNA structural determination. It has proximal homologous DNA binding domains Box-A, Box-B and distal C-terminal domain. Reduced form exists in
Tripathi A, Shrinet K, Kumar A.
europepmc +4 more sources
Adenovirus protein VII binds the A-box of HMGB1 to repress interferon responses. [PDF]
PLoS Pathogens, 2023 Viruses hijack host proteins to promote infection and dampen host defenses. Adenovirus encodes the multifunctional protein VII that serves both to compact viral genomes inside the virion and disrupt host chromatin.
Edward A Arnold +6 more
doaj +2 more sources
The Comprehensive Role of High Mobility Group Box 1 (HMGB1) Protein in Different Tumors: A Pan-Cancer Analysis [PDF]
Journal of Inflammation Research, 2023 Hui Guan,1 Ming Zhong,1 Kongyang Ma,2 Chun Tang,1 Xiaohua Wang,1 Muzi Ouyang,3 Rencai Qin,2 Jiasi Chen,1 Enyi Zhu,1 Ting Zhu,1 Yongping Lu,1 Yu Liu,1 Chengzi Tian,4 Zhihua Zheng1 1Department of Nephrology, Center of Kidney and Urology, The Seventh ...
Guan H +13 more
doaj +2 more sources
Analysis of glycyrrhizin binding to protein HMGB1
Medicine in Drug Discovery, 2020 Glycyrrhizin (GLR) is triterpenoid saponin used for the treatment of various of liver and skin diseases. GLR blocks the nucleocytoplasmic translocation of the protein HMGB1, thereby inhibiting its extracellular release and its functions as a damage-associated molecular pattern molecule.
Christian Bailly
exaly +3 more sources
The redox-sensitive protein HMGB1: intracellular and extracellular roles
Experimental and Molecular MedicineHMGB1 is a non-histone nuclear protein that is primarily located in the nucleus. It can be translocated to the cytoplasm and secreted into the extracellular space upon stimulation.
Man Sup Kwak +3 more
doaj +3 more sources
Redox Biology, 2021 Oxidative stress can induce covalent disulfide bond formation between protein-protein thiol groups and generate hydroxyl free radicals that damage DNA. HMGB1 is a DNA chaperone and damage-associated molecular pattern molecule.
Man Sup Kwak +6 more
doaj +1 more source
Virulence, 2021 High mobility group box 1 (HMGB1), a ubiquitous DNA-binding protein, can be released into extracellular space and function as a strong proinflammatory cytokine, which plays critical roles in the pathogenesis of various inflammatory diseases.
Wenqing Fan +3 more
doaj +1 more source