C-terminal domain of nonhistone protein HMGB1 as a modulator of HMGB1–DNA structural interactions [PDF]
Spectroscopy, 2010 The HMGB1 protein (High Mobility Group protein 1) participates in the formation of functionally significant DNA-protein complexes. HMGB1 protein contains two DNA-binding domains and negatively charged C-terminal region. The latter consists of continuous sequence of dicarboxylic amino acids residues.
Chikhirzhina, E. +4 more
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Redox properties of the A‐domain of the HMGB1 protein [PDF]
FEBS Letters, 2008 MINT‐6795963: txn (uniprotkb:P10599) and HMGB1 (uniprotkb:P09429) bind
Sahu, Debashish +3 more
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The telomeric protein TERF2/TRF2 impairs HMGB1-driven autophagy [PDF]
Autophagy, 2022 TERF2/TRF2 is a pleiotropic telomeric protein that plays a crucial role in tumor formation and progression through several telomere-dependent and -independent mechanisms. Here, we uncovered a novel function for this protein in regulating the macroautophagic/autophagic process upon different stimuli. By using both biochemical and cell biology approaches,
Iachettini Sara +8 more
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Inhibition of HMGB1/RAGE-mediated endocytosis by HMGB1 antagonist box A, anti-HMGB1 antibodies, and cholinergic agonists suppresses inflammation [PDF]
Molecular Medicine, 2019 Background Extracellular high mobility group box 1 protein (HMGB1) serves a central role in inflammation as a transporter protein, which binds other immune-activating molecules that are endocytosed via the receptor for advanced glycation end-products ...
Huan Yang +12 more
doaj +3 more sources
Histone H1 Differentially Inhibits DNA Bending by Reduced and Oxidized HMGB1 Protein. [PDF]
PLoS ONE, 2015 HMGB1 protein and linker histone H1 have overlapping binding sites in the nucleosome. HMGB1 has been implicated in many DNA-dependent processes in chromatin involving binding of specific proteins, including transcription factors, to DNA sites pre-bent by
Michal Štros +3 more
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Emerging roles for HMGB1 protein in immunity, inflammation, and cancer [PDF]
ImmunoTargets and Therapy, 2015 High-mobility group box 1 (HMGB1) protein is a member of the highly conserved non-histone DNA binding protein family. First identified in 1973, as one of a group of chromatin-associated proteins with high acidic and basic amino acid content, it was so named for its characteristic rapid mobility in polyacrylamide gel electrophoresis.
MARTINOTTI, Simona +2 more
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The nuclear protein HMGB1, a new kind of chemokine? [PDF]
FEBS Letters, 2003 The chromosomal protein HMGB1 is now regarded as a proinflammatory cytokine. Importantly, HMGB1 has chemotactic activity suggesting its involvement in the early and late events of the inflammatory reaction. Therefore, HMGB1 has all the hallmarks of a chemokine (chemotactic cytokine).
Degryse, Bernard, de Virgilio, Maddalena
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Determinants of Specific Binding of HMGB1 Protein to Hemicatenated DNA Loops [PDF]
Journal of Molecular Biology, 2005 Protein HMGB1 has long been known as one of the most abundant non-histone proteins in the nucleus of mammalian cells, and has regained interest recently for its function as an extracellular cytokine. As a DNA-binding protein, HMGB1 facilitates DNA-protein interactions by increasing the flexibility of the double helix, and binds specifically to ...
Jaouen, Sandrine +5 more
openaire +5 more sources
High-Mobility Group Box 1 (Hmgb1) Protein Evaluation in Mptp-Induced Zebrafish Model of Parkinson’s Disease [PDF]
, 2021 Molecular studies have proven beneficial in understanding the pathophysiology of PD. Besides, the advancing application of zebrafish as a PD model has enabled researchers to conduct molecular studies with more promising outcomes and significance. Current
Mohamed, Wael +6 more
core +1 more source
Reappraisal of oxidized HMGB1 as a mediator and biomarker
Future Science OA, 2022 HMGB1 is a dual-function protein that acts as a chromatin-binding protein and as a danger-associated molecular pattern (DAMP) when released from activated immune cells or injured tissue.
Ross Pirnie +3 more
doaj +1 more source