Results 31 to 40 of about 41,752 (255)
Intracellular HMGB1: defender of client proteins and cell fate
Oncotarget, 2015 Inflammatory and infectious diseases are often characterized by large amounts of epithelial cell death. This is particularly true for the inflammatory bowel diseases (IBD) of the gastrointestinal tract. Under normal homeostatic conditions, epithelial cells lining the intestines (IEC) undergo an orderly progression from undifferentiated, self-renewing ...
Jeannette, Messer, Eugene, Chang
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Evidence for Involvement of HMGB1 Protein in Human DNA Mismatch Repair [PDF]
Journal of Biological Chemistry, 2004 Defects in human DNA mismatch repair predispose to cancer, but many components of the pathway have not been identified. We report here the identification and characterization of a novel component required for mismatch repair in human cells. A 30-kDa protein was purified to homogeneity by virtue of its ability to complement a depleted HeLa extract in ...
Fenghua, Yuan +4 more
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Mediators of Inflammation, 2012 Cardiac hypertrophy is an independent predictor of cardiovascular morbidity and mortality. In recent years, evidences suggest that high-mobility group box 1 (HMGB1) protein, an inflammatory cytokine, participates in cardiac remodeling; however, the ...
Fei-fei Su +6 more
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HMGB1 mediates lipopolysaccharide-induced macrophage autophagy and pyroptosis
BMC Molecular and Cell Biology, 2023 Autophagy and pyroptosis of macrophages play important protective or detrimental roles in sepsis. However, the underlying mechanisms remain unclear.
Jiawei Shang +5 more
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PRRSV Induces HMGB1 Phosphorylation at Threonine-51 Residue to Enhance Its Secretion
Viruses, 2022 Porcine reproductive and respiratory syndrome virus (PRRSV) induces secretion of high mobility group box 1 (HMGB1) to mediate inflammatory response that is involved in the pulmonary injury of infected pigs.
Rong Wang +8 more
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Recognition of DNA Interstrand Cross-link of Antitumor Cisplatin by HMGB1 Protein, [PDF]
Biochemistry, 2003 Several proteins that specifically bind to DNA modified by cisplatin, including those containing HMG-domains, mediate antitumor activity of this drug. Oligodeoxyribonucleotide duplexes containing a single, site-specific interstrand cross-link of cisplatin were probed for recognition by the rat chromosomal protein HMGB1 and its domains A and B using the
Jana, Kasparkova +6 more
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European Journal of Inflammation, 2014 Close talk between inflammatory mediators and immunological cytokines has been discovered and reported. In this study, the role of nuclear factor of activated T cell-2 (NFAT2) in regulation of high mobility group box-1 (HMGB1) release was investigated ...
H. Liu +6 more
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PLoS ONE, 2014 HMGB1 is a nuclear component involved in nucleosome stabilization and transcription regulation, but extracellularly it is able to serve as a potential late mediator of lethality.
Noriyuki Kuroda +5 more
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Regulation of Neurogenesis in Mouse Brain by HMGB1
Cells, 2020 The High Mobility Group Box 1 (HMGB1) is the most abundant nuclear nonhistone protein that is involved in transcription regulation. In addition, HMGB1 has previously been found as an extracellularly acting protein enhancing neurite outgrowth in cultured ...
Xiang Zhao +4 more
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Emerging roles for HMGB1 protein in immunity, inflammation, and cancer
ImmunoTargets and Therapy, 2015 High-mobility group box 1 (HMGB1) protein is a member of the highly conserved non-histone DNA binding protein family. First identified in 1973, as one of a group of chromatin-associated proteins with high acidic and basic amino acid content, it was so named for its characteristic rapid mobility in polyacrylamide gel electrophoresis.
MARTINOTTI, Simona +2 more
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