Results 51 to 60 of about 45,099 (293)
HMGB1-RAGE Axis Makes No Contribution to Cardiac Remodeling Induced by Pressure-Overload. [PDF]
, 2016 High-mobility group box1 (HMGB1) exerts effects on inflammation by binding to receptor for advanced glycation end products (RAGE) or Toll-like receptor 4.
Hairuo Lin (3161859) +25 more
core +1 more source
Post-translational modifications on protein VII are not required for HMGB1 binding but are important to render HMGB1 insoluble. [PDF]
, 2023 A. Schematic of point mutations in VII∆PTM expressed in A549 cells with doxycycline (dox) inducible promoter. B. B2H results of interaction between protein VII∆PTM and HMGB1 constructs as depicted. C.
Monica S. Guo (16979653) +6 more
core +1 more source
Propofol inhibits invasion and migration of esophageal squamous carcinoma cell line KYSE150 through miR-218 [PDF]
Jichu yixue yu linchuang, 2020 Objective To investigate the effect of propofol on invasion and migration of esophageal squamous cancer cell line KYSE150 and potential mechanism. Methods KYSE150 cells were treated with 0, 2.5, 5 and 10 μg/L propofol,Transwell chamber and scratch assay ...
GAO Hong, JIN Hui, LIU Chun-zhi, YANG Jing-yuan
doaj
Regulation of Neurogenesis in Mouse Brain by HMGB1
Cells, 2020 The High Mobility Group Box 1 (HMGB1) is the most abundant nuclear nonhistone protein that is involved in transcription regulation. In addition, HMGB1 has previously been found as an extracellularly acting protein enhancing neurite outgrowth in cultured ...
Xiang Zhao +4 more
doaj +1 more source
Intracellular HMGB1: defender of client proteins and cell fate
Oncotarget, 2015 Inflammatory and infectious diseases are often characterized by large amounts of epithelial cell death. This is particularly true for the inflammatory bowel diseases (IBD) of the gastrointestinal tract. Under normal homeostatic conditions, epithelial cells lining the intestines (IEC) undergo an orderly progression from undifferentiated, self-renewing ...
Jeannette, Messer, Eugene, Chang
openaire +2 more sources
European Journal of Inflammation, 2014 Close talk between inflammatory mediators and immunological cytokines has been discovered and reported. In this study, the role of nuclear factor of activated T cell-2 (NFAT2) in regulation of high mobility group box-1 (HMGB1) release was investigated ...
H. Liu +6 more
doaj +1 more source
PLoS ONE, 2014 HMGB1 is a nuclear component involved in nucleosome stabilization and transcription regulation, but extracellularly it is able to serve as a potential late mediator of lethality.
Noriyuki Kuroda +5 more
doaj +1 more source
Journal of Translational Medicine, 2012 Background High mobility group box 1(HMGB1) overexpression has been reported in a variety of human cancers. However, the role of HMGB1 in hepatocellular carcinoma (HCC) remains unclear.
Liu Furong +5 more
doaj +1 more source
Evidence for Involvement of HMGB1 Protein in Human DNA Mismatch Repair [PDF]
Journal of Biological Chemistry, 2004 Defects in human DNA mismatch repair predispose to cancer, but many components of the pathway have not been identified. We report here the identification and characterization of a novel component required for mismatch repair in human cells. A 30-kDa protein was purified to homogeneity by virtue of its ability to complement a depleted HeLa extract in ...
Fenghua, Yuan +4 more
openaire +2 more sources
Recognition of DNA Interstrand Cross-link of Antitumor Cisplatin by HMGB1 Protein, [PDF]
Biochemistry, 2003 Several proteins that specifically bind to DNA modified by cisplatin, including those containing HMG-domains, mediate antitumor activity of this drug. Oligodeoxyribonucleotide duplexes containing a single, site-specific interstrand cross-link of cisplatin were probed for recognition by the rat chromosomal protein HMGB1 and its domains A and B using the
Jana, Kasparkova +6 more
openaire +2 more sources