Results 71 to 80 of about 45,099 (293)

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Elevation of Proinflammatory Cytokine HMGB1 in the Synovial Fluid of Patients With Legg‐Calvé‐Perthes Disease and Correlation With IL‐6

JBMR Plus, 2021
Legg‐Calvé‐Perthes disease (LCPD) is a childhood ischemic osteonecrosis (ON) of the femoral head associated with the elevation of proinflammatory cytokine interleukin‐6 (IL‐6) in the synovial fluid.
Nobuhiro Kamiya, Harry KW Kim
doaj   +1 more source

Role of HMGB1 Protein in Experimental Myocardial Infarction

The FASEB Journal, 2019
Introduction Myocardial infarction (MI) results from a reduction in coronary blood flow which is extensive enough to render the oxygen supply to myocardial tissues insufficient. MI remains a leading cause of morbidity and mortality among all cardiovascular diseases over the world.
Martina Cebova, Andrej Barta, Michaela Kosutova, Olga Pechanova   +3 more
openaire   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Pull‐and‐Push Nanotherapeutic Hydrogels: Scavenging Inflammatory Triggers While Driving Tissue Regeneration in Burn Wounds

Advanced Functional Materials, EarlyView.
A nanounit‐assembled hydrogel employing a “pull‐and‐push” strategy simultaneously scavenges pro‐inflammatory cell‐free DNA (cfDNA) and delivers regenerative therapeutics in response to burn‐induced hyperthermia. By repolarizing macrophages and promoting angiogenesis, this multifunctional platform accelerates burn wound healing, offering a blueprint for
Han‐Sem Kim, Seong‐Jin Shin, Sak Lee, Nandin Mandakhbayar, Ji‐Hye Kang, Da‐Young Kong, Seong‐Doo Hong, Ueon Sang Shin, Hae‐Won Kim, Jung‐Hwan Lee   +9 more
wiley   +1 more source

HMGB-1 - a novel mediator of inflammatory-induced renal epithelial mesenchymal transition [PDF]

, 2010
Background: High mobility group box protein 1 (HMGB-1) is a chromatin binding protein that bends DNA thereby facilitating gene transcription. HMGB-1 has also been observed as an extracellular secreted protein in serum of patients with sepsis and has ...
Ryan, Michael P., Michael P. Ryan, Slattery, Craig, Tara McMorrow, Nolan, Stephen, Ronan Feighery, Craig Slattery, Feighery, Ronan, Stephen Nolan, Julie Lynch, Lynch, Julie, McMorrow, Tara   +11 more
core   +1 more source

Stepwise release of biologically active HMGB1 during HSV-2 infection. [PDF]

PLoS ONE, 2011
BACKGROUND: High mobility group box 1 protein (HMGB1) is a major endogenous danger signal that triggers inflammation and immunity during septic and aseptic stresses. HMGB1 recently emerged as a key soluble factor in the pathogenesis of various infectious
Chloé Borde, Stéphanie Barnay-Verdier, Claire Gaillard, Hakim Hocini, Vincent Maréchal, Joël Gozlan   +5 more
doaj   +1 more source

Temporal Immune and Metabolic Shifts Drive the Anti‐Tumor Efficacy of Resiquimod‐Loaded Nanoparticles in Peritoneal Carcinomatosis

Advanced Healthcare Materials, EarlyView.
Peritoneal carcinomatosis is a hard‐to‐treat spread of abdominal cancers that often returns after therapy. Nanoparticles were developed to retain an immune‐boosting drug in the abdomen. When combined with chemotherapy in mice, this approach eliminated tumors in many cases and prevented recurrence, helping the immune system mount a stronger, longer ...
Vanessa Chan, Po‐Han Chao, XuXin Sun, Jun Han, Sarah MacPherson, Lucas J. Andrew, Noah Y. Brittain, Tien Do, Marcel B. Bally, Julian J. Lum, Shyh‐Dar Li   +10 more
wiley   +1 more source

Increased dermal expression of chromatin-associated protein HMGB1 and concomitant T-cell expression of the DNA RAGE in patients with psoriasis vulgaris [PDF]

, 2019
Lisa Strohbuecker,1 Hans Koenen,2 Esther van Rijssen,2 Bram van Cranenbroek,2 Esther Fasse,2 Irma Joosten,2 Andreas Körber,1 Christoph Bergmann3 1Department of Dermatology, University Hospital Essen, 45147 Essen, Germany; 2Department of Laboratory ...
van Rijssen E, Joosten I, van Cranenbroek B, Fasse E, Körber A, Koenen H, Bergmann C, Strohbuecker L   +7 more
core  

Sputum biomarkers and the prediction of clinical outcomes in patients with cystic fibrosis. [PDF]

, 2012
Lung function, acute pulmonary exacerbations (APE), and weight are the best clinical predictors of survival in cystic fibrosis (CF); however, underlying mechanisms are incompletely understood.
Rogers, S.L., Sturrock, A., Carveth, Holly, William Walsh, Christen Lane, Walsh, W., James Moore, Li, Yanping, Keogh, R.H., Cox, D.R., Jun Chen (4238), Li, Y., Holly Carveth (143299), Carveth Holly, Judy L. Jensen (143284), William Walsh (143288), Anne Sturrock (143317), Liou Theodore G., Robert Paine III (143322), Ruth H. Keogh (143278), Paine, Robert, Teresa Clark (143295), Hoidal, John R, Cox David R., Adler Frederick R., Moore James, Hoidal John R., Liou, T.G., Shaunessy L. Rogers (143305), Rogers Shaunessy L., David R. Cox (77429), John R. Hoidal (143328), Lane Christen, Lane, C., Ruth H Keogh, Chen, Jun, Packer Kristyn, Kristyn Packer (143291), Frederick R. Adler (143274), Packer, K., Paine Robert, Clark, Teresa, Keogh, Ruth H, Anne Sturrock, Paine, R., Theodore G Liou, David R Cox, Robert Paine, Walsh William, Packer, Kristyn, Hoidal, J.R., Jensen, Judy L, Sturrock, Anne, Yanping Li (90163), Moore, J., Sturrock Anne, Kristyn Packer, Shaunessy L Rogers, Frederick R Adler, Adler, F.R., Clark, T., Rogers, Shaunessy L, Jensen, J.L., Yanping Li, Keogh Ruth H., Chen Jun, Adler, Frederick R, Jun Chen, Liou, Theodore G, Clark Teresa, Theodore G. Liou (143270), Judy L Jensen, John R Hoidal, Li Yanping, Lane, Christen, Christen Lane (143311), Holly Carveth, Chen, J., James Moore (22922), Walsh, William, Teresa Clark, Carveth, H., Jensen Judy L., Cox, David R, Moore, James   +84 more
core   +1 more source