Results 41 to 50 of about 41,752 (255)
Journal of Translational Medicine, 2012 Background High mobility group box 1(HMGB1) overexpression has been reported in a variety of human cancers. However, the role of HMGB1 in hepatocellular carcinoma (HCC) remains unclear.
Liu Furong +5 more
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Neuropathic pain in rats with a partial sciatic nerve ligation is alleviated by intravenous injection of monoclonal antibody to high mobility group box-1. [PDF]
PLoS ONE, 2013 High mobility group box-1 (HMGB1) is associated with the pathogenesis of inflammatory diseases. A previous study reported that intravenous injection of anti-HMGB1 monoclonal antibody significantly attenuated brain edema in a rat model of stroke, possibly
Yoki Nakamura +7 more
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Targeting Inflammation Driven by HMGB1
Frontiers in Immunology, 2020 High mobility group box 1 (HMGB1) is a highly conserved, nuclear protein present in all cell types. It is a multi-facet protein exerting functions both inside and outside of cells.
Huan Yang, Haichao Wang, Ulf Andersson
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Propofol inhibits invasion and migration of esophageal squamous carcinoma cell line KYSE150 through miR-218 [PDF]
Jichu yixue yu linchuang, 2020 Objective To investigate the effect of propofol on invasion and migration of esophageal squamous cancer cell line KYSE150 and potential mechanism. Methods KYSE150 cells were treated with 0, 2.5, 5 and 10 μg/L propofol,Transwell chamber and scratch assay ...
GAO Hong, JIN Hui, LIU Chun-zhi, YANG Jing-yuan
doaj
Role of HMGB1 Protein in Experimental Myocardial Infarction
The FASEB Journal, 2019 Introduction Myocardial infarction (MI) results from a reduction in coronary blood flow which is extensive enough to render the oxygen supply to myocardial tissues insufficient. MI remains a leading cause of morbidity and mortality among all cardiovascular diseases over the world.
Martina Cebova +3 more
openaire +1 more source
Computational and Structural Biotechnology Journal, 2019 High-mobility Group Box 1 (HMGB1) is an abundant protein present in all mammalian cells and involved in several processes. During inflammation or tissue damage, HMGB1 is released in the extracellular space and, depending on its redox state, can form a ...
Enrico M.A. Fassi +7 more
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
FEBS Open Bio, EarlyView.We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa +2 more
wiley +1 more source
Advanced Functional Materials, EarlyView.A nanounit‐assembled hydrogel employing a “pull‐and‐push” strategy simultaneously scavenges pro‐inflammatory cell‐free DNA (cfDNA) and delivers regenerative therapeutics in response to burn‐induced hyperthermia. By repolarizing macrophages and promoting angiogenesis, this multifunctional platform accelerates burn wound healing, offering a blueprint for
Han‐Sem Kim +9 more
wiley +1 more source
Antioxidants, 2020 High-mobility group box 1 (HMGB1) is a protein that is part of a larger family of non-histone nuclear proteins. HMGB1 is a ubiquitary protein with different isoforms, linked to numerous physiological and pathological pathways.
Marcella Nebbioso +6 more
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