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The telomeric protein TERF2/TRF2 impairs HMGB1-driven autophagy
Autophagy, 2022 TERF2/TRF2 is a pleiotropic telomeric protein that plays a crucial role in tumor formation and progression through several telomere-dependent and -independent mechanisms. Here, we uncovered a novel function for this protein in regulating the macroautophagic/autophagic process upon different stimuli. By using both biochemical and cell biology approaches,
Iachettini Sara +8 more
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Molecular Medicine, 2019 Background Extracellular high mobility group box 1 protein (HMGB1) serves a central role in inflammation as a transporter protein, which binds other immune-activating molecules that are endocytosed via the receptor for advanced glycation end-products ...
Huan Yang +12 more
doaj +1 more source
The nuclear protein HMGB1, a new kind of chemokine? [PDF]
FEBS Letters, 2003 The chromosomal protein HMGB1 is now regarded as a proinflammatory cytokine. Importantly, HMGB1 has chemotactic activity suggesting its involvement in the early and late events of the inflammatory reaction. Therefore, HMGB1 has all the hallmarks of a chemokine (chemotactic cytokine).
Degryse, Bernard, de Virgilio, Maddalena
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Molecular Medicine, 2013 High mobility group box 1 (HMGB1) is a DNA-binding protein that possesses cytokinelike, proinflammatory properties when released extracellularly in the C23–C45 disulfide form. HMGB1 also plays a key role as a mediator of acute and chronic inflammation in
Sodam Kim +8 more
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Determinants of Specific Binding of HMGB1 Protein to Hemicatenated DNA Loops [PDF]
Journal of Molecular Biology, 2005 Protein HMGB1 has long been known as one of the most abundant non-histone proteins in the nucleus of mammalian cells, and has regained interest recently for its function as an extracellular cytokine. As a DNA-binding protein, HMGB1 facilitates DNA-protein interactions by increasing the flexibility of the double helix, and binds specifically to ...
Jaouen, Sandrine +5 more
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Identification and characterization of the lamprey high-mobility group box 1 gene. [PDF]
PLoS ONE, 2012 High-mobility group box 1 (HMGB1), a highly conserved DNA-binding protein, plays an important role in maintaining nucleosome structures, transcription, and inflammation. We identified a homolog of HMGB1 in the Japanese lamprey (Lampetra japonica).
Yue Pang, Rong Xiao, Xin Liu, Qingwei Li
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High mobility group box 1 induced human lung myofibroblasts differentiation and enhanced migration by activation of MMP-9. [PDF]
PLoS ONE, 2015 High mobility group box 1 (HMGB1) is a nuclear protein that involves the binding with DNA and influences chromatin regulation and transcription. HMGB1 is also a cytokine that can activate monocytes and neutrophils involved in inflammation. In this study,
Chen-Chen Lee +4 more
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Zhongliu Fangzhi Yanjiu, 2018 Objective To investigate the role of High-mobility group box-1 (HMGB1) protein in regulating the expression of cancer stem cell markers Nanog, OCT4 and Sox2.
WANG Hua +4 more
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HMGB1: A novel Beclin 1-binding protein active in autophagy [PDF]
Autophagy, 2010 The autophagosome delivers damaged cytoplasmic constituents and proteins to the lysosome or to the extracellular space. Beclin 1, an essential: autophagic protein, is a BH3-only protein that binds Bcl-2 anti-apoptotic family members and has a critical role in the initiation of autophagy.
Rui, Kang +4 more
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Aberrant Expression of High Mobility Group Box Protein 1 in the Idiopathic Inflammatory Myopathies
Frontiers in Cell and Developmental Biology, 2020 IntroductionHigh Mobility Group Box Protein 1 (HMGB1) is a DNA-binding protein that exerts inflammatory or pro-repair effects upon translocation from the nucleus.
Jessica Day +16 more
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