Results 21 to 30 of about 45,099 (293)

The Effect and Regulatory Mechanism of High Mobility Group Box-1 Protein on Immune Cells in Inflammatory Diseases

open access: yesCells, 2021
High mobility group box-1 protein (HMGB1), a member of the high mobility group protein superfamily, is an abundant and ubiquitously expressed nuclear protein.
Yun Ge, Man Huang, Yong-ming Yao
doaj   +1 more source

Protein VII directly binds HMGB1. [PDF]

open access: yes, 2023
A. Left: Schematic of the bacterial two-hybrid (B2H) assay. Right: Empty vectors or no interaction between the bait and prey proteins results in beige colony (top and middle) while a direct interaction results in pink colony (bottom). B.
Monica S. Guo (16979653)   +6 more
core   +1 more source

HMGB1 Translocation in Neurons after Ischemic Insult: Subcellular Localization in Mitochondria and Peroxisomes

open access: yesCells, 2020
High mobility group box-1 (HMGB1), a nonhistone chromatin DNA-binding protein, is released from neurons into the extracellular space under ischemic, hemorrhagic, and traumatic insults. However, the details of the time-dependent translocation of HMGB1 and
Dengli Wang   +7 more
doaj   +1 more source

Elevated HMGB1 promotes the malignant progression and contributes to cisplatin resistance of non-small cell lung cancer

open access: yesHereditas, 2023
Background HMGB1 (high mobility group box B-1) exhibits crucial role in tumor genesis and development, including lung cancer. Whereas, more HMGB1-related details in non-small cell lung cancer (NSCLC) are still largely unclear.
Ying Ma   +4 more
doaj   +1 more source

Magnesium sulfate reduces vascular endothelial cell apoptosis in rats with preeclampsia via the miR-218-5p/HMGB1 pathway

open access: yesClinical and Experimental Hypertension, 2022
Objective This study aims to investigate the mechanism by which magnesium sulfate regulates the miR-218-5p/HMGB-pathway-mediated apoptosis of vascular endothelial cells (VECs) in rats with preeclampsia (PE).
Jiacui Zheng   +5 more
doaj   +1 more source

High Mobility Group Box 1 (HMGB1) Induces Toll-Like Receptor 4-Mediated Production of the Immunosuppressive Protein Galectin-9 in Human Cancer Cells [PDF]

open access: yes, 2021
High mobility group box 1 (HMGB1) is a non-histone protein which is predominantly localised in the cell nucleus. However, stressed, dying, injured or dead cells can release this protein into the extracellular matrix passively.
Klenova, Elena   +11 more
core   +1 more source

Binding of histone H1 to DNA is differentially modulated by redox state of HMGB1. [PDF]

open access: yesPLoS ONE, 2014
HMGB1 is an architectural protein in chromatin, acting also as a signaling molecule outside the cell. Recent reports from several laboratories provided evidence that a number of both the intracellular and extracellular functions of HMGB1 may depend on ...
Eva Polanská   +2 more
doaj   +1 more source

Post-Translational Modification of HMGB1 Disulfide Bonds in Stimulating and Inhibiting Inflammation

open access: yesCells, 2021
High mobility group box 1 protein (HMGB1), a highly conserved nuclear DNA-binding protein, is a “damage-associated molecular pattern” molecule (DAMP) implicated in both stimulating and inhibiting innate immunity.
Ulf Andersson   +2 more
doaj   +1 more source

Correlation between MMP-9 and extracellular cytokine HMGB1 in prediction of human ischemic stroke outcome [PDF]

open access: yes, 2014
Ischemic stroke (IS) outcome predictors include clinical features, biochemical parameters and some risk factors. The relations between two main players in the ischemic brain, MMPs and HMGB1, were estimated in the plasma of ischemic stroke patients ...
Kalandadze, Iagor   +7 more
core   +1 more source

NMR studies of DNA recognition mechanism of HMGB1 protein [PDF]

open access: yesNucleic Acids Symposium Series, 2009
A 2'-deoxyuridylate dimer cyclized via cross-linkage by an ethylene (U(et)(p)U) or a propylene (U(pr)(p)U) linker at the 5-position was incorporated into DNA oligomers. Fluorescence resonance energy transfer (FRET) experiments showed that they bent at approximately 90 degrees .
Kyoko, Furuita   +5 more
openaire   +2 more sources

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