Damage-associated molecular patterns (DAMPs) in diseases: implications for therapy [PDF]
Molecular BiomedicineDamage-associated molecular patterns (DAMPs) are endogenous danger signal molecules released by damaged, stressed or dead cells that bind to pattern recognition receptors (PRRs), activating immune responses and inflammatory signaling pathways to play ...
Heya Lin +4 more
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Role of Damage-Associated Molecular Patterns (DAMPs/Alarmins) in Severe Ocular Allergic Diseases [PDF]
Cells, 2022 Severe ocular allergic diseases, such as atopic keratoconjunctivitis and vernal keratoconjunctivitis, cause severe allergic inflammation in the conjunctiva and corneal epithelial damage, resulting in visual disturbances. The involvement of damage (danger)
Ken Fukuda +6 more
doaj +4 more sources
Old and new damage‐associated molecular patterns (DAMPs) in autoimmune diseases
Rheumatology & Autoimmunity, 2022 All organisms living in complex environments have evolved effective mechanisms of dynamic responses to extracellular stimuli. The immune system activates when damaged or injured cells release damage‐associated molecular patterns (DAMPs).
Na Kang +3 more
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Untangling Local Pro-Inflammatory, Reparative, and Regulatory Damage-Associated Molecular-Patterns (DAMPs) Pathways to Improve Transplant Outcomes [PDF]
Frontiers in Immunology, 2021 Detrimental inflammatory responses after solid organ transplantation are initiated when immune cells sense pathogen-associated molecular patterns (PAMPs) and certain damage-associated molecular patterns (DAMPs) released or exposed during transplant ...
Gaelen K. Dwyer +4 more
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Damage-Associated Molecular Patterns (DAMPs) in Retinal Disorders. [PDF]
Int J Mol Sci, 2022 Damage-associated molecular patterns (DAMPs) are endogenous danger molecules released from the extracellular and intracellular space of damaged tissue or dead cells. Recent evidence indicates that DAMPs are associated with the sterile inflammation caused by aging, increased ocular pressure, high glucose, oxidative stress, ischemia, mechanical trauma ...
Mahaling B +7 more
europepmc +5 more sources
Role of Damage-Associated Molecular Patterns (DAMPS) in the Postoperative Period after Colorectal Surgery. [PDF]
Int J Mol Sci, 2023 Anastomotic leakage (AL) is a defect of the intestinal wall at the anastomotic site and is one of the most severe complications in colorectal surgery. Previous studies have shown that the immune system response plays a significant role in the development of AL.
Caballero-Herrero MJ +4 more
europepmc +4 more sources
Mitochondrial dysfunction and damage associated molecular patterns (DAMPs) in chronic inflammatory diseases. [PDF]
Mitochondrion, 2018 Inflammation represents a comprehensive host response to external stimuli for the purpose of eliminating the offending agent, minimizing injury to host tissues and fostering repair of damaged tissues back to homeostatic levels. In normal physiologic context, inflammatory response culminates with the resolution of infection and tissue damage response ...
Dela Cruz CS, Kang MJ.
europepmc +5 more sources
The Role of Damage-Associated Molecular Patterns (DAMPs) in Human Diseases : Part II: DAMPs as diagnostics, prognostics and therapeutics in clinical medicine [PDF]
Sultan Qaboos University Medical Journal, 2015 This article is the second part of a review that addresses the role of damage-associated molecular patterns (DAMPs) in human diseases by presenting examples of traumatic (systemic inflammatory response syndrome), cardiovascular (myocardial infarction ...
Walter G. Land
doaj +6 more sources
Damage-associated molecular patterns (DAMPs) released after burn are associated with inflammation and monocyte activation. [PDF]
Burns, 2017 Burns are associated with activation of the innate immunity that can contribute to complications. Damage-associated molecular patterns (DAMPs) released after tissue injury play a critical role in the activation of the innate immunity, which appears to be mediated via toll-like receptors (TLRs).
Rani M +3 more
europepmc +5 more sources
Beyond pathogens: a narrative review of the immunological nexus of damage-associated molecular patterns and inflammasome activation in sterile AECOPD [PDF]
Frontiers in ImmunologyThe acute exacerbation of chronic obstructive pulmonary disease (AECOPD) has traditionally been attributed to pathogen-associated molecular patterns (PAMPs); however, emerging evidence highlights the critical role of damage-associated molecular patterns (
Chenwen Peng +13 more
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