Results 11 to 20 of about 41,481 (235)

Protraction of neuropathic pain by morphine is mediated by spinal damage associated molecular patterns (DAMPs) in male rats. [PDF]

Brain Behav Immun, 2018
We have recently reported that a short course of morphine, starting 10days after sciatic chronic constriction injury (CCI), prolonged the duration of mechanical allodynia for months after morphine ceased. Maintenance of this morphine-induced persistent sensitization was dependent on spinal NOD-like receptor protein 3 (NLRP3) inflammasomes-protein ...
Grace PM, Strand KA, Galer EL, Rice KC, Maier SF, Watkins LR.   +5 more
europepmc   +6 more sources

Damage-associated molecular patterns (DAMPs) in vascular diseases. [PDF]

J Biol Chem
Research into the role of chronic sterile inflammation (i.e., a prolonged inflammatory state not caused by an infectious agent) in vascular disease progression has continued to grow over the last few decades. DAMPs have a critical role in this research due to their ability to link stress-causing cardiovascular risk factors to inflammatory phenotypes ...
Antonello J, Roy P.
europepmc   +3 more sources

Mitochondrial damage-associated molecular patterns (mito-DAMPs): Determinants of hepatopathy progression and therapeutic implications

Pharmacological Research
Liver diseases, as the primary representative disorders of the digestive tract, encompass metabolic dysfunction-associated steatotic liver disease (MASLD), liver fibrosis, and malignant liver or gallbladder cancers and pose a significant health challenge
Ranyi Luo, Yun Yang, Yinhao Zhang, Xiaoyong Xue, Mengyu Guo, Xiaojiaoyang Li   +5 more
doaj   +3 more sources

Damage-associated molecular patterns in vitiligo: igniter fuse from oxidative stress to melanocyte loss

Redox Report, 2022
Objectives The pathogenesis of vitiligo remains unclear. In this review, we comprehensively describe the role of damage associated molecular patterns (DAMPs) during vitiligo pathogenesis.Methods Published papers on vitiligo, oxidative stress and DAMPs ...
Jingying Wang, Yinghao Pan, Guangmin Wei, Hanxiao Mao, Rulan Liu, Yuanmin He   +5 more
doaj   +1 more source

The Damage-Associated Molecular Patterns (DAMPs) as Potential Targets to Treat Osteoarthritis: Perspectives From a Review of the Literature. [PDF]

Front Med (Lausanne), 2020
During the osteoarthritis (OA) process, activation of immune systems, whether innate or adaptive, is strongly associated with low-grade systemic inflammation. This process is initiated and driven in the synovial membrane, especially by synovium cells, themselves previously activated by damage-associated molecular patterns (DAMPs) released during ...
Lambert C, Zappia J, Sanchez C, Florin A, Dubuc JE, Henrotin Y.   +5 more
europepmc   +6 more sources

Role of Damage-Associated Molecular Pattern/Cell Death Pathways in Vaccine-Induced Immunity

Viruses, 2021
Immune responses induced by natural infection and vaccination are known to be initiated by the recognition of microbial patterns by cognate receptors, since microbes and most vaccine components contain pathogen-associated molecular patterns.
Sun Min Lee, Paul Kim, Jinsuh You, Eui Ho Kim   +3 more
doaj   +1 more source

Danger signals in traumatic hemorrhagic shock and new lines for clinical applications

Frontiers in Physiology, 2023
Hemorrhage is the leading cause of death in severe trauma injuries. When organs or tissues are subjected to prolonged hypoxia, danger signals—known as damage-associated molecular patterns (DAMPs)—are released into the intercellular environment.
Frédérique Dufour-Gaume, Nadira Frescaline, Venetia Cardona, Nicolas J. Prat   +3 more
doaj   +1 more source

Bullatacin triggers immunogenic cell death of colon cancer cells by activating endoplasmic reticulum chaperones

Journal of Inflammation, 2021
Background It is well accepted that the immune system efficiently contributes to positive outcomes of chemotherapeutic cancer treatment by activating immunogenic cell death (ICD).
Fangtian Fan, Peiliang Shen, Yue Ma, Wangbo Ma, Hongyan Wu, Hao Liu, Qing An   +6 more
doaj   +1 more source

AIM/CD5L attenuates DAMPs in the injured brain and thereby ameliorates ischemic stroke

Cell Reports, 2021
Summary: The sterile inflammation caused by damage-associated molecular patterns (DAMPs) worsens the prognosis following primary injury such as ischemic stroke. However, there are no effective treatments to regulate DAMPs.
Natsumi Maehara, Kaori Taniguchi, Ami Okuno, Hideaki Ando, Aika Hirota, Zhiheng Li, Ching-Ting Wang, Satoko Arai, Toru Miyazaki   +8 more
doaj   +1 more source

In silico selection of damage-associated molecular patterns (DAMPS) and their receptors in humans

Research, Society and Development, 2022
Damage-associated molecular patterns (DAMPs) are intracellular molecules released into the extracellular environment after injury. These are recognized by pattern recognition receptors (PRRs) and activate the innate immune system, triggering an inflammatory response.
Erika Aparecida Oliveira, Rebeca Louise de Araujo Brabosa, Wanderley José Mantovani Bittencourt, Laura Cristina Jardim Porto Pimenta, Luciano José Pereira, Elaine Maria Seles Dorneles, Ana Paula Peconick   +6 more
openaire   +2 more sources