Damage-associated molecular patterns (DAMPs) in diseases: implications for therapy [PDF]
Molecular BiomedicineDamage-associated molecular patterns (DAMPs) are endogenous danger signal molecules released by damaged, stressed or dead cells that bind to pattern recognition receptors (PRRs), activating immune responses and inflammatory signaling pathways to play ...
Heya Lin +4 more
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Inflammation and damage-associated molecular patterns in major psychiatric disorders [PDF]
Trends in Psychiatry and Psychotherapy, 2023 Background Emerging evidence indicates that inflammation plays an important role as a mechanism underlying mental disorders. However, most of the research on inflammatory mechanisms focuses on serum levels of interleukins and very few studies have ...
Fernanda Endler Valiati +7 more
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Damage-associated molecular patterns and coagulation. [PDF]
Br J HaematolDamage‐associated molecular patterns (DAMPs), released into the extracellular space following tissue injury, are increasingly recognised as potent procoagulant molecules integral to haemostasis and the pathogenesis of thrombosis. Their procoagulant influence spans all phases of the cell‐based model of coagulation while simultaneously extending beyond ...
Yong J, Toh CH.
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Damage-associated molecular patterns (DAMPs) in vascular diseases. [PDF]
J Biol ChemResearch into the role of chronic sterile inflammation (i.e., a prolonged inflammatory state not caused by an infectious agent) in vascular disease progression has continued to grow over the last few decades. DAMPs have a critical role in this research due to their ability to link stress-causing cardiovascular risk factors to inflammatory phenotypes ...
Antonello J, Roy P.
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Mitochondria-Derived Damage-Associated Molecular Patterns in Neurodegeneration [PDF]
Frontiers in Immunology, 2017 Inflammation is increasingly implicated in neurodegenerative disease pathology. As no acquired pathogen appears to drive this inflammation, the question of what does remains.
Russell H. Swerdlow +9 more
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Damage-Associated Molecular Patterns and Pattern Recognition Receptors in the Podocyte. [PDF]
J Am Soc NephrolPodocytes possess immune system components allowing for a variety of innate responses to endogenous and exogenous stimuli. Recently, several groups have linked inappropriate innate immune signaling to podocyte injury, particularly chronic, sustained injury; however, the immune capabilities of podocytes have not been fully elucidated.
Myette RL +6 more
europepmc +4 more sources
Damage-Associated Molecular Patterns (DAMPs) in Retinal Disorders. [PDF]
Int J Mol Sci, 2022 Damage-associated molecular patterns (DAMPs) are endogenous danger molecules released from the extracellular and intracellular space of damaged tissue or dead cells. Recent evidence indicates that DAMPs are associated with the sterile inflammation caused by aging, increased ocular pressure, high glucose, oxidative stress, ischemia, mechanical trauma ...
Mahaling B +7 more
europepmc +4 more sources
Changes of Damage Associated Molecular Patterns in COVID-19 Patients
Infectious Diseases & Immunity, 2021 . Background:. The development of severe coronavirus disease 2019 (COVID-19) is associated with systemic hyperinflammation, which drives multi-organ failure and death.
Xing Fan +14 more
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Kinetics of Circulating Damage-Associated Molecular Patterns in Sepsis [PDF]
Journal of Immunology Research, 2015 Circulating levels of conventional biomarkers and damage-associated molecular patterns were examined in 30 severe sepsis patients (20 survivors and 10 nonsurvivors).
Takahiro Miki, Toshiaki Iba
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Damage-associated molecular patterns in bacteraemic infection, including a comparative analysis with bacterial DNA, a pathogen-associated molecular pattern [PDF]
Scientific ReportsDamage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs) are key triggers of inflammation in sepsis. However, they have rarely been studied simultaneously.
Helena Alpkvist +7 more
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