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Sterile inflammation in laminopathies [PDF]
European Journal of Cell BiologySterile inflammation, an immune response triggered in the absence of pathogens, plays a key role in various chronic diseases, including aging-related disorders, cancer, and autoimmune conditions.
Rafael Cancado de Faria, Susana Gonzalo
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Sterile inflammation in liver transplantation [PDF]
Frontiers in Medicine, 2023 Sterile inflammation is the immune response to damage-associated molecular patterns (DAMPs) released during cell death in the absence of foreign pathogens. In the setting of solid organ transplantation, ischemia-reperfusion injury results in mitochondria-
Riley Kahan +6 more
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Damage-mediated macrophage polarization in sterile inflammation [PDF]
Frontiers in Immunology, 2023 Most of the leading causes of death, such as cardiovascular diseases, cancer, dementia, neurodegenerative diseases, and many more, are associated with sterile inflammation, either as a cause or a consequence of these conditions.
Gábor Koncz +8 more
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SHP2‐Triggered Endothelial Cell Activation Fuels Estradiol‐Independent Endometrial Sterile Inflammation [PDF]
Advanced ScienceSterile inflammation occurs in various chronic diseases due to many nonmicrobe factors. Examples include endometrial hyperplasia (EH), endometriosis, endometrial cancer, and breast cancer, which are all sterile inflammation diseases induced by estrogen ...
Jie Pan +10 more
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Sterile inflammation and the NLRP3 inflammasome in cardiometabolic disease [PDF]
Biomedical Journal, 2023 Inflammation plays an important role in the pathophysiology of cardiometabolic diseases. Sterile inflammation, a non-infectious and damage-associated molecular pattern (DAMP)-induced innate response, is now well-established to be closely associated with ...
Sungji Cho, Fan Ying, Gary Sweeney
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HMGB1 is a mediator of cuproptosis-related sterile inflammation [PDF]
Frontiers in Cell and Developmental Biology, 2022 Cuproptosis is a recently recognized modality of cell death driven by intracellular copper-dependent mitochondrial stress. However, the mediators of the sterile inflammatory response to cuproptotic death are undetermined.
Jiao Liu +4 more
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Frontiers in Immunology, 2013 Inflammation is a coordinated response of the immune system which is aimed at maintaining or restoring tissue integrity. Sterile inflammation can be triggered by physical, chemical, or metabolic noxious stimuli. The individual stimuli (genomic stress, ER stress, hypoxic stress, nutrient stress, etc.) promote a carefully choreographed set of cell ...
Anna eRubartelli +3 more
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STING Signaling and Sterile Inflammation [PDF]
Frontiers in Immunology, 2021 Innate immunity is regulated by a broad set of evolutionary conserved receptors to finely probe the local environment and maintain host integrity. Besides pathogen recognition through conserved motifs, several of these receptors also sense aberrant or ...
Isabelle Couillin, Nicolas Riteau
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Sterile Inflammation in Drosophila [PDF]
Mediators of Inflammation, 2015 The study of immune responses in Drosophila has already yielded significant results with impacts on our understanding of vertebrate immunity, such as the characterization of the Toll receptor. Several recent papers have focused on the humoral response to
Zeeshan Shaukat +2 more
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Cerebral sterile inflammation in neurodegenerative diseases [PDF]
Inflammation and Regeneration, 2020 Therapeutic strategies for regulating neuroinflammation are expected in the development of novel therapeutic agents to prevent the progression of central nervous system (CNS) pathologies. An understanding of the detailed molecular and cellular mechanisms
Kento Otani, Takashi Shichita
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