Sterile inflammation in MASH: emerging role of extracellular RNA and therapeutic strategies [PDF]
npj Metabolic Health and DiseaseMetabolic dysfunction-associated steatotic liver disease (MASLD) and its advanced form, metabolic dysfunction-associated steatohepatitis (MASH), are major global health issues involving metabolic dysfunction, hepatic lipotoxicity, and chronic ...
Sana Raza +6 more
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The Role of Non-LTR Retrotransposons in Sterile Inflammation: Mechanisms and Therapeutic Potential [PDF]
BiomedicinesNon-long terminal repeat (Non-LTR) retrotransposons are mobile genetic elements that replicate through a “copy-and-paste” mechanism, enabling their expansion within the genome.
Hua Yang +8 more
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Sterile inflammation: sensing and reacting to damage [PDF]
Nature Reviews Immunology, 2010 Over the past several decades, much has been revealed about the nature of the host innate immune response to microorganisms, with the identification of pattern recognition receptors (PRRs) and pathogen-associated molecular patterns, which are the conserved microbial motifs sensed by these receptors.
Grace Y Chen +2 more
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Sterile inflammation of peritoneal membrane caused by peritoneal dialysis: focus on the communication between immune cells and peritoneal stroma [PDF]
Frontiers in ImmunologyPeritoneal dialysis is a widely used method for treating kidney failure. However, over time, the peritoneal structure and function can deteriorate, leading to the failure of this therapy.
Hongyong Su +9 more
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Distinguishing sterile inflammation from graft infection [PDF]
Journal of Cardiothoracic SurgeryWe describe the case of a 68-year-old man who underwent ascending aortic replacement and thoracic endovascular aortic repair. Four years later, the patient developed neck pain on the right side and chest computed tomography showed expansion of fluid in ...
Atsuyuki Mitsuishi +3 more
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Mitochondrial ACOD1/IRG1 in infection and sterile inflammation. [PDF]
J Intensive Med, 2022 Immunometabolism is a dynamic process involving the interplay of metabolism and immune response in health and diseases. Increasing evidence suggests that impaired immunometabolism contributes to infectious and inflammatory diseases. In particular, the mitochondrial enzyme aconitate decarboxylase 1 (ACOD1, best known as immunoresponsive gene 1 [IRG1 ...
Wu R, Kang R, Tang D.
europepmc +3 more sources
Crosstalk between myocardial autophagy and sterile inflammation in the development of heart failure [PDF]
Autophagy ReportsHeart failure, a leading driver of global mortality, remains a topic of intense contemporary research interest due to the prevailing unmet need in cardiometabolic therapeutics. Numerous mechanisms with the potential to influence the onset and development
Jialing Tang +4 more
doaj +2 more sources
Sterile inflammation alters neutrophil kinetics in mice. [PDF]
J Leukoc Biol, 2022 Abstract Neutrophils play a crucial role in establishing inflammation in response to an infection or injury, but their production rates, as well as blood and tissue residence times, remain poorly characterized under these conditions.
Alakesh A +3 more
europepmc +4 more sources
Hemopexin alleviates sterile inflammation in ischemia-reperfusion-induced lung injury [PDF]
Frontiers in ImmunologyIntroductionPulmonary ischemia-reperfusion (IR) injury (IRI) plays a significant role in various lung disorders and is a key factor in the development of primary graft dysfunction following lung transplantation.
Tomoyuki Nakagiri +14 more
doaj +2 more sources
Identifying biomarkers deciphering sepsis from trauma-induced sterile inflammation and trauma-induced sepsis [PDF]
Frontiers in Immunology, 2023 ObjectiveThe purpose of this study was to identify a panel of biomarkers for distinguishing early stage sepsis patients from non-infected trauma patients.BackgroundAccurate differentiation between trauma-induced sterile inflammation and real infective ...
Praveen Papareddy +11 more
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