Pathogen-associated molecular patterns alter molecular clock gene expression in mouse splenocytes. [PDF]
PLoS ONE, 2017 Circadian rhythms are endogenous 24-h oscillations that influence a multitude of physiological processes. The pathogen-associated molecular pattern (PAMP), lipopolysaccharide, has been shown to modify the circadian molecular clock.
Adam C Silver
doaj +7 more sources
Helicobacter pylori Pathogen-Associated Molecular Patterns: Friends or Foes? [PDF]
Int J Mol Sci, 2022 Microbial infections are sensed by the host immune system by recognizing signature molecules called Pathogen-Associated Molecular Patterns—PAMPs. The binding of these biomolecules to innate immune receptors, called Pattern Recognition Receptors (PRRs), alerts the host cell, activating microbicidal and pro-inflammatory responses.
Eletto D +5 more
europepmc +6 more sources
Targeting Cytokines, Pathogen-Associated Molecular Patterns, and Damage-Associated Molecular Patterns in Sepsis via Blood Purification. [PDF]
Int J Mol Sci, 2021 Sepsis is characterized by a dysregulated immune response to infections that causes life-threatening organ dysfunction and even death. When infections occur, bacterial cell wall components (endotoxin or lipopolysaccharide), known as pathogen-associated molecular patterns, bind to pattern recognition receptors, such as toll-like receptors, to initiate ...
Moriyama K, Nishida O.
europepmc +6 more sources
COPD disease severity and innate immune response to pathogen-associated molecular patterns [PDF]
International Journal of COPD, 2016 Vincent S Fan,1,2 Sina A Gharib,2,3 Thomas R Martin,1,2 Mark M Wurfel2 1VA Puget Sound Health Care System, Seattle, WA, USA; 2Division of Pulmonary & Critical Care Medicine, Department of Medicine, University of Washington, Seattle WA, USA ...
Fan VS, Gharib SA, Martin TR, Wurfel MM
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Peripheral neural detection of danger-associated and pathogen-associated molecular patterns. [PDF]
Crit Care Med, 2013 Bidirectional links between the nervous and immune systems modulate inflammation. The cellular mechanisms underlying the detection of danger-associated molecular patterns and pathogen-associated molecular patterns by the nervous system are not well understood.
Ackland GL +4 more
europepmc +9 more sources
Structural basis for recognition of N-formyl peptides as pathogen-associated molecular patterns [PDF]
Nature Communications, 2022 Detection of invading bacteria is key to immunity. Here, the authors report cryo-electron microscopy structures of agonist-bound formyl peptide receptor 1 (FPR1), that reveal structural basis for recognition of bacteria-derived formyl peptides.
Geng Chen +14 more
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Scientific ReportsDamage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs) are key triggers of inflammation in sepsis. However, they have rarely been studied simultaneously.
Helena Alpkvist +7 more
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Natural and synthetic pathogen associated molecular patterns modulate galectin expression in cow blood [PDF]
Journal of Animal Science and Technology, 2019 Pathogen-associated Molecular Patterns (PAMPs) are highly conserved structural motifs that are recognized by Pathogen Recognition receptors (PRRs) to initiate immune responses.
Emmanuel Kwaku Asiamah +5 more
doaj +2 more sources
The Effects of Pathogen-Associated Molecular Patterns on Peripheral Blood Monocytes in Patients with Non-alcoholic Fatty Liver Disease. [PDF]
J Clin Exp Hepatol, 2022 Li Q, Rempel JD, Yang J, Minuk GY.
europepmc +2 more sources
Macrophages disseminate pathogen associated molecular patterns through the direct extracellular release of the soluble content of their phagolysosomes. [PDF]
Nat Commun, 2022 Recognition of pathogen-or-damage-associated molecular patterns is critical to inflammation. However, most pathogen-or-damage-associated molecular patterns exist within intact microbes/cells and are typically part of non-diffusible, stable macromolecules
Greene CJ +12 more
europepmc +3 more sources