Results 41 to 50 of about 407,636 (275)

Mitochondrial damage-associated molecular patterns and vascular function [PDF]

European Heart Journal, 2014
Immune system activation occurs not only due to foreign stimuli, but also due to endogenous molecules. As such, endogenous molecules that are released into the circulation due to cell death and/or injury alarm the immune system that something has disturbed homeostasis and a response is needed.
Camilla Ferreira, Wenceslau, Cameron G, McCarthy, Theodora, Szasz, Kathryn, Spitler, Styliani, Goulopoulou, R Clinton, Webb   +5 more
openaire   +2 more sources

The Roles of Mitochondrial Damage-Associated Molecular Patterns in Diseases [PDF]

Antioxidants & Redox Signaling, 2015
Mitochondria, vital cellular power plants to generate energy, are involved in immune responses. Mitochondrial damage-associated molecular patterns (DAMPs) are molecules that are released from mitochondria to extracellular space during cell death and include not only proteins but also DNA or lipids.
Kiichi, Nakahira, Shu, Hisata, Augustine M K, Choi   +2 more
openaire   +2 more sources

Key Events Participating in the Pathogenesis of  Alcoholic Liver Disease

Biomolecules, 2017
Alcoholic liver disease (ALD) is a leading cause of morbidity and mortality worldwide. It ranges from fatty liver to steatohepatitis, fibrosis, cirrhosis and hepatocellular carcinoma.The most prevalent forms of ALD are alcoholic fatty liver, alcoholic ...
Fernando Magdaleno, Chuck C. Blajszczak, Natalia Nieto   +2 more
doaj   +1 more source

Damage-Associated Molecular Patterns Control Neutrophil Recruitment [PDF]

Journal of Innate Immunity, 2013
Neutrophils are recruited to a site of infection or injury where they help initiate the acute inflammatory response. In instances of sterile inflammation, where no microbial threats are present, this neutrophil recruitment is mediated by the release of danger signals or damage-associated molecular patterns (DAMPs) from disrupted cells and tissues.
Keir, Pittman, Paul, Kubes
openaire   +2 more sources

Activation and regulation mechanisms of NOD-like receptors based on structural biology

Frontiers in Immunology, 2022
Innate immunity is a primary defense system against microbial infections. Innate immune pattern recognition receptors (PRRs) play pivotal roles in detection of invading pathogens.
Umeharu Ohto
doaj   +1 more source

Damage-Associated Molecular Pattern-Triggered Immunity in Plants [PDF]

Frontiers in Plant Science, 2019
كعملية عالمية في الكائنات متعددة الخلايا، بما في ذلك الحيوانات والنباتات، عادة ما تصدر الخلايا إشارات خطر عند المعاناة من هجمات الميكروبات والحيوانات العاشبة، أو الأضرار المادية. تشمل هذه الإشارات، التي يطلق عليها الأنماط الجزيئية المرتبطة بالضرر (DAMPs)، بشكل أساسي جدار الخلية أو شظايا البروتين خارج الخلية والببتيدات والنيوكليوتيدات والأحماض الأمينية.
Sen Hou, Zunyong Liu, Hexi Shen, Daoji Wu   +3 more
openaire   +3 more sources

Bullatacin triggers immunogenic cell death of colon cancer cells by activating endoplasmic reticulum chaperones

Journal of Inflammation, 2021
Background It is well accepted that the immune system efficiently contributes to positive outcomes of chemotherapeutic cancer treatment by activating immunogenic cell death (ICD).
Fangtian Fan, Peiliang Shen, Yue Ma, Wangbo Ma, Hongyan Wu, Hao Liu, Qing An   +6 more
doaj   +1 more source

Damage-associated molecular patterns in cancer: a double-edged sword [PDF]

Oncogene, 2016
Damage-associated molecular patterns (DAMPs) are released in response to cell death and stress, and are potent triggers of sterile inflammation. Recent evidence suggests that DAMPs may also have a key role in the development of cancer, as well as in the host response to cytotoxic anti-tumor therapy.
Hernandez, Celine, Huebener, Peter, Schwabe, Robert F.   +2 more
openaire   +2 more sources

High-risk alcohol consumption is associated with mitochondrial damage-associated molecular patterns in people living with HIV. [PDF]

Drug Alcohol Depend Rep
Alcohol (i.e., ethanol; EtOH) use disorders are common in people with HIV (PWH) and are associated with poor health outcomes. One potential reason for these poor health outcomes in PWH is that alcohol use is associated with mitochondrial damage and ...
Gilstrap SR, Ho MD, Hobson JM, White-Gilliam DM, Freij K, Owens MA, Cody SL, Thomas SJ, Sorge RE, Goodin BR.   +9 more
europepmc   +2 more sources

Cross Kingdom Immunity: The Role of Immune Receptors and Downstream Signaling in Animal and Plant Cell Death

Frontiers in Immunology, 2021
Both plants and animals are endowed with sophisticated innate immune systems to combat microbial attack. In these multicellular eukaryotes, innate immunity implies the presence of cell surface receptors and intracellular receptors able to detect danger ...
Thibault Roudaire, Marie-Claire Héloir, David Wendehenne, Aymeric Zadoroznyj, Aymeric Zadoroznyj, Laurence Dubrez, Laurence Dubrez, Benoit Poinssot   +7 more
doaj   +1 more source