Results 1 to 10 of about 9,358 (229)
Schizophrenia and Alarmins [PDF]
Medicina, 2022 Schizophrenia, consisting of a group of severe psychiatric disorders with a complex etiology, is a leading cause of disability globally. Due to the lack of objective indicators, accurate diagnosis and selection of effective treatments for schizophrenia ...
Huan Ma, Ning Cheng, Caiyi Zhang
doaj +4 more sources
Monoclonal Antibodies Targeting Alarmins: A New Perspective for Biological Therapies of Severe Asthma [PDF]
Biomedicines, 2021 Alarmins are innate cytokines, including thymic stromal lymphopoietin (TSLP), interleukin-33 (IL-33), and interleukin-25 (IL-25), which are mainly produced by airway epithelium and exert a prominent role in asthma pathobiology.
Alessandro Vatrella +2 more
exaly +6 more sources
Role of Damage-Associated Molecular Patterns (DAMPs/Alarmins) in Severe Ocular Allergic Diseases [PDF]
Cells, 2022 Severe ocular allergic diseases, such as atopic keratoconjunctivitis and vernal keratoconjunctivitis, cause severe allergic inflammation in the conjunctiva and corneal epithelial damage, resulting in visual disturbances. The involvement of damage (danger)
Kenji Yamashiro +2 more
exaly +4 more sources
Alarmins, COVID-19 and comorbidities [PDF]
Annals of Medicine, 2021 The coronavirus SARS-CoV-2, the aetiological agent of COVID-19 disease, is representing a worldwide threat for the medical community and the society at large so that it is being defined as “the twenty-first-century disease”.
Eleonora Di Salvo +4 more
doaj +6 more sources
The Role of Alarmins in the Pathogenesis of Rheumatoid Arthritis, Osteoarthritis, and Psoriasis [PDF]
Current Issues in Molecular BiologyAlarmins are immune-activating factors released after cellular injury or death. By secreting alarmins, cells can interact with immune cells and induce a variety of inflammatory responses.
Andrzej Pawlik +2 more
exaly +4 more sources
Alarmins in Osteoporosis, RAGE, IL-1, and IL-33 Pathways: A Literature Review [PDF]
Medicina (Lithuania), 2020 Alarmins are endogenous mediators released by cells following insults or cell death to alert the host’s innate immune system of a situation of danger or harm.
Sebastiano Gangemi +2 more
exaly +5 more sources
Alarmins in Chronic Spontaneous Urticaria: Immunological Insights and Therapeutic Perspectives [PDF]
BiomedicinesBackground: In the world, approximately 1% of the population suffers from chronic spontaneous urticaria (CSU), burdening patients’ quality of life and challenging clinicians in terms of treatment.
Sebastiano Gangemi +2 more
exaly +4 more sources
Alarmins: Feel the Stress [PDF]
The Journal of Immunology, 2017 Abstract Over the last decade, danger-associated molecular pattern molecules, or alarmins, have been recognized as signaling mediators of sterile inflammatory responses after trauma and injury. In contrast with the accepted passive release models suggested by the “danger hypothesis,” it was recently shown that alarmins can also directly ...
Rider, P. +5 more
core +6 more sources
Alarmins and c-Jun N-Terminal Kinase (JNK) Signaling in Neuroinflammation [PDF]
Cells, 2020 Neuroinflammation is involved in the progression or secondary injury of multiple brain conditions, including stroke and neurodegenerative diseases.
Nina D. Anfinogenova +3 more
doaj +2 more sources
Alarmins: awaiting a clinical response [PDF]
Journal of Clinical Investigation, 2012 Alarmins are endogenous molecules that are constitutively available and released upon tissue damage and activate the immune system. Current evidence indicates that uncontrolled and excessive release of alarmins contributes to the dysregulated processes seen in many inflammatory and autoimmune conditions, as well as tumorigenesis and cancer spread ...
Chan, James K +7 more
openaire +5 more sources