Results 41 to 50 of about 9,358 (229)

Alarmin‐induced cell migration [PDF]

European Journal of Immunology, 2013
Alarmins are endogenous, constitutively available, damage‐associated molecular patterns that upon release can mobilize and activate various leukocytes for the induction of innate and adaptive immune responses. For our immune system to function appropriately, it relies on navigating various leukocytes to distinct places at the right time.
De, Yang, Feng, Wei, Poonam, Tewary, O M Zack, Howard, Joost J, Oppenheim   +4 more
openaire   +2 more sources

Non-Vesicular Release of Alarmin Prothymosin α Complex Associated with Annexin-2 Flop-Out

Cells, 2023
Nuclear protein prothymosin α (ProTα) is a unique member of damage-associated molecular patterns (DAMPs)/alarmins. ProTα prevents neuronal necrosis by causing a cell death mode switch in serum-starving or ischemic/reperfusion models in vitro and in vivo.
Hiroshi Ueda
doaj   +1 more source

Brain-released alarmins and stress response synergize in accelerating atherosclerosis progression after stroke. [PDF]

, 2018
Stroke induces a multiphasic systemic immune response, but the consequences of this response on atherosclerosis-a major source of recurrent vascular events-have not been thoroughly investigated.
Singh, Vikramjeet, Huber, G., Stefan Roth, Gauberti, M., Bianchi, Marco E., Gauberti, Maxime, Helena Erlandsson Harris, Antoine Anfray, Georg Huber, Tiedt, Steffen, Maxime Gauberti, Huber, Georg, Daniel J. Antoine, Holdt, Lesca M., Orset, C., Bernhagen, Jürgen, Christof Haffner, Engelhardt, Britta, Harris, H.E., Britta Engelhardt, Antoine, Daniel J., Martin Dichgans, Marco E. Bianchi, Bianchi, M.E., Vivien, D., Roth, Stefan, Schindler, L., Holdt, L.M., Engelhardt, B., Cyrille Orset, Bianchi, Marco E, Fournier, A., Geerlof, Arie, Fournier, Antoine, Orset, Cyrille, Geerlof, A., Bernhagen, J., Vivien, Denis, Lesca M. Holdt, Liesz, A., Schindler, Lisa, Anfray, A., Harris, Helena Erlandsson, Liesz, Arthur, Denis Vivien, Steffen Tiedt, Jürgen Bernhagen, Holdt, Lesca M, Vikramjeet Singh, Arthur Liesz, Haffner, C., Singh, V.K., Antoine Fournier, Antoine, D.J., Anfray, Antoine, Antoine, Daniel J, Dichgans, Martin, Tiedt, S., Haffner, Christof, Lisa Schindler, Roth, S., Arie Geerlof, Dichgans, M.   +62 more
core   +1 more source

Glucose Induces IL-1α-Dependent Inflammation and Extracellular Matrix Proteins Expression and Deposition in Renal Tubular Epithelial Cells in Diabetic Kidney Disease

Frontiers in Immunology, 2020
Diabetes mellitus is linked with metabolic stress that induces cellular damage and can provoke renal inflammation and fibrotic responses that eventually lead to chronic kidney disease. Because the inflammasome, interleukin 1 (IL-1), IL-1α/IL-β, and IL-1R
Talal Salti, Khaled Khazim, Khaled Khazim, Khaled Khazim, Rami Haddad, Salvatore Campisi-Pinto, Gil Bar-Sela, Gil Bar-Sela, Idan Cohen   +8 more
doaj   +1 more source

The Role of Alarmins in the Pathogenesis of Asthma. [PDF]

Biomolecules
Asthma is defined as a chronic respiratory disease, the processes of which are mainly related to the hyperreactivity of the immune system. Airway hyperresponsiveness and remodeling are other hallmarks of asthma that are strongly involved in the progression of the disease.
Plewa P, Pokwicka J, Bakinowska E, Kiełbowski K, Pawlik A.   +4 more
europepmc   +4 more sources

Involvement of Oxidative Stress in Protective Cardiac Functions of Calprotectin

Cells, 2022
Calprotectin (CLP) belonging to the S-100 protein family is a heterodimeric complex (S100A8/S100A9) formed by two binding proteins. Upon cell activation, CLP stored in neutrophils is released extracellularly in response to inflammatory stimuli and acts ...
Luc Rochette, Geoffrey Dogon, Eve Rigal, Marianne Zeller, Yves Cottin, Catherine Vergely   +5 more
doaj   +1 more source

Alarmins and Related Molecules in Elective Surgery

Folia Biologica, 2023
Surgery is associated with alterations of alarmins’ and related molecules’ levels. The aim of this study was to investigate which biomarkers are most involved in surgery. The studied group consisted of 58 patients with inguinal or umbilical hernia or cholecystolithiasis and 21 healthy controls for compa­rison.
Sabina, Strohalmová, Kateřina, Levová, Aleš Antonín, Kuběna, David, Hoskovec, Zdeněk, Krška, Tomáš, Zima, Marta, Kalousová   +6 more
openaire   +2 more sources

Targeting alarmin release reverses Sjogren's syndrome phenotype by revitalizing Ca2+ signalling

Clinical and Translational Medicine, 2023
Background Primary Sjogren's syndrome (pSS) is a systemic autoimmune disease that is embodied by the loss of salivary gland function and immune cell infiltration, but the mechanism(s) are still unknown.
Yuyang Sun, Viviane Nascimento Da Conceicao, Arun Chauhan, Pramod Sukumaran, Pooja Chauhan, Julian L. Ambrus, Arjan Vissink, Frans G. M. Kroese, Madesh Muniswamy, Bibhuti B. Mishra, Brij B. Singh   +10 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Proteomics reveals distinct mechanisms regulating the release of cytokines and alarmins during pyroptosis [PDF]

, 2021
A major pathway for proinflammatory protein release by macrophages is inflammasome-mediated pyroptotic cell death. As conventional secretion, unconventional secretion, and cell death are executed simultaneously, however, the cellular mechanisms ...
Phulphagar, Kshiti, Frauenstein, Annika, Rieckmann, J., Swietlik, J., Meissner, F., Ebner, S., Phulphagar, K., Frauenstein, A., Rieckmann, Jan, Meissner, Felix, Swietlik, Jonathan J., Kuehn, L., Kühn, Lars I., Ebner, Stefan   +13 more
core   +2 more sources