Results 41 to 50 of about 1,269 (186)

Alarmin‐induced cell migration [PDF]

European Journal of Immunology, 2013
Alarmins are endogenous, constitutively available, damage‐associated molecular patterns that upon release can mobilize and activate various leukocytes for the induction of innate and adaptive immune responses. For our immune system to function appropriately, it relies on navigating various leukocytes to distinct places at the right time.
De, Yang, Feng, Wei, Poonam, Tewary, O M Zack, Howard, Joost J, Oppenheim   +4 more
openaire   +2 more sources

Glucose Induces IL-1α-Dependent Inflammation and Extracellular Matrix Proteins Expression and Deposition in Renal Tubular Epithelial Cells in Diabetic Kidney Disease

Frontiers in Immunology, 2020
Diabetes mellitus is linked with metabolic stress that induces cellular damage and can provoke renal inflammation and fibrotic responses that eventually lead to chronic kidney disease. Because the inflammasome, interleukin 1 (IL-1), IL-1α/IL-β, and IL-1R
Talal Salti, Khaled Khazim, Khaled Khazim, Khaled Khazim, Rami Haddad, Salvatore Campisi-Pinto, Gil Bar-Sela, Gil Bar-Sela, Idan Cohen   +8 more
doaj   +1 more source

Targeting alarmin release reverses Sjogren's syndrome phenotype by revitalizing Ca2+ signalling

Clinical and Translational Medicine, 2023
Background Primary Sjogren's syndrome (pSS) is a systemic autoimmune disease that is embodied by the loss of salivary gland function and immune cell infiltration, but the mechanism(s) are still unknown.
Yuyang Sun, Viviane Nascimento Da Conceicao, Arun Chauhan, Pramod Sukumaran, Pooja Chauhan, Julian L. Ambrus, Arjan Vissink, Frans G. M. Kroese, Madesh Muniswamy, Bibhuti B. Mishra, Brij B. Singh   +10 more
doaj   +1 more source

Involvement of Oxidative Stress in Protective Cardiac Functions of Calprotectin

Cells, 2022
Calprotectin (CLP) belonging to the S-100 protein family is a heterodimeric complex (S100A8/S100A9) formed by two binding proteins. Upon cell activation, CLP stored in neutrophils is released extracellularly in response to inflammatory stimuli and acts ...
Luc Rochette, Geoffrey Dogon, Eve Rigal, Marianne Zeller, Yves Cottin, Catherine Vergely   +5 more
doaj   +1 more source

Alarmins and Related Molecules in Elective Surgery

Folia Biologica, 2023
Surgery is associated with alterations of alarmins’ and related molecules’ levels. The aim of this study was to investigate which biomarkers are most involved in surgery. The studied group consisted of 58 patients with inguinal or umbilical hernia or cholecystolithiasis and 21 healthy controls for compa­rison.
Sabina, Strohalmová, Kateřina, Levová, Aleš Antonín, Kuběna, David, Hoskovec, Zdeněk, Krška, Tomáš, Zima, Marta, Kalousová   +6 more
openaire   +2 more sources

Novel Biological Therapies for Severe Asthma Endotypes

Biomedicines, 2022
Severe asthma comprises several heterogeneous phenotypes, underpinned by complex pathomechanisms known as endotypes. The latter are driven by intercellular networks mediated by molecular components which can be targeted by specific monoclonal antibodies.
Corrado Pelaia, Giulia Pelaia, Claudia Crimi, Angelantonio Maglio, Anna Agnese Stanziola, Cecilia Calabrese, Rosa Terracciano, Federico Longhini, Alessandro Vatrella   +8 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A Cross-Sectional and Longitudinal Study to Define Alarmins and A-SAA Variants as Companion Markers in Early Rheumatoid Arthritis

Frontiers in Immunology, 2021
Nowadays, in the study of rheumatoid arthritis (RA), more and more interest is directed towards an earlier effective therapeutic intervention and the determination of companion markers for predicting response to therapy with the goal to prevent ...
Federica Ciregia, Gwenaël Nys, Gaël Cobraiville, Valérie Badot, Silvana Di Romana, Paschalis Sidiras, Tatiana Sokolova, Patrick Durez, Marianne Fillet, Michel G. Malaise, Dominique de Seny   +10 more
doaj   +1 more source

The Role of Airway Epithelial Cell Alarmins in Asthma

, 2022
The airway epithelium is the first line of defense for the lungs, detecting inhaled environmental threats through pattern recognition receptors expressed transmembrane or intracellularly.
Gail M. Gauvreau, Christiane E. Whetstone, Hafsa Omer, Maral Ranjbar, Ruth P. Cusack   +4 more
core   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source