Results 41 to 50 of about 10,508 (186)

Targeting alarmin release reverses Sjogren's syndrome phenotype by revitalizing Ca2+ signalling

Clinical and Translational Medicine, 2023
Background Primary Sjogren's syndrome (pSS) is a systemic autoimmune disease that is embodied by the loss of salivary gland function and immune cell infiltration, but the mechanism(s) are still unknown.
Yuyang Sun, Viviane Nascimento Da Conceicao, Arun Chauhan, Pramod Sukumaran, Pooja Chauhan, Julian L. Ambrus, Arjan Vissink, Frans G. M. Kroese, Madesh Muniswamy, Bibhuti B. Mishra, Brij B. Singh   +10 more
doaj   +1 more source

The Role of Airway Epithelial Cell Alarmins in Asthma

, 2022
The airway epithelium is the first line of defense for the lungs, detecting inhaled environmental threats through pattern recognition receptors expressed transmembrane or intracellularly.
Gail M. Gauvreau, Christiane E. Whetstone, Hafsa Omer, Maral Ranjbar, Ruth P. Cusack   +4 more
core   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Novel Biological Therapies for Severe Asthma Endotypes

Biomedicines, 2022
Severe asthma comprises several heterogeneous phenotypes, underpinned by complex pathomechanisms known as endotypes. The latter are driven by intercellular networks mediated by molecular components which can be targeted by specific monoclonal antibodies.
Corrado Pelaia, Giulia Pelaia, Claudia Crimi, Angelantonio Maglio, Anna Agnese Stanziola, Cecilia Calabrese, Rosa Terracciano, Federico Longhini, Alessandro Vatrella   +8 more
doaj   +1 more source

Role of alarmins in perioperative medicine. [PDF]

, 2018
Introduction: Inflammatory response (IR) is a fundamental reaction to the cell and tissue injury. It is aimed at correcting the pathologic condition and maintaining the structural and functional integrity of the organism. The insult with too extensive or
Máca, Jan
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A Cross-Sectional and Longitudinal Study to Define Alarmins and A-SAA Variants as Companion Markers in Early Rheumatoid Arthritis

Frontiers in Immunology, 2021
Nowadays, in the study of rheumatoid arthritis (RA), more and more interest is directed towards an earlier effective therapeutic intervention and the determination of companion markers for predicting response to therapy with the goal to prevent ...
Federica Ciregia, Gwenaël Nys, Gaël Cobraiville, Valérie Badot, Silvana Di Romana, Paschalis Sidiras, Tatiana Sokolova, Patrick Durez, Marianne Fillet, Michel G. Malaise, Dominique de Seny   +10 more
doaj   +1 more source

Topically Delivered Treg‐Attracting Microparticle‐Hydrogel Composites Recruit Regulatory T Cells and Limit Cardiac Injury After Severe Ischemia

Advanced Healthcare Materials, EarlyView.
CCL22‐releasing PLGA microparticles (MP) suspended in topically applied hydrogels (HEART) establish a sustained chemokine gradient at the injured myocardium. HEART recruits CCR4+ regulatory T cells, reduces infarct size and graft fibrosis, and improves cardiac function.
Matthew A. Borrelli, Alexis T. Reese, Jordan J. P. Warunek, Betsy Ann Varghese, Canxing Lin, Jeffery J. Baust, Brenda McMahon, Steven R. Little, Hēth R. Turnquist   +8 more
wiley   +1 more source

Role of Alarmins in the Pathogenesis of Systemic Sclerosis

, 2020
Systemic sclerosis (SSc) is a rare chronic autoimmune disease associated with significant morbidity and mortality. Two main subsets of SSc are recognized: (i) diffuse cutaneous SSc with rapidly progressive fibrosis of the skin, lungs, and other internal ...
Casciaro M., Gangemi S., Rosato E., Straface E., Giovannetti A., Pioggia G., Marco Casciaro, Elisabetta Straface, Antonello Giovannetti, Sebastiano Gangemi, Edoardo Rosato, Giovanni Pioggia   +11 more
core   +2 more sources

Alarmins and their pivotal role in the pathogenesis of spontaneous abortion: insights for therapeutic intervention

European Journal of Medical Research
Alarmins are a class of molecules released when affected cells damaged or undergo apoptosis. They contain various chemotactic and immunomodulatory proteins or peptides.
Qiqi Zhang, Dandan Yang, Xingxing Han, Yu Ren, Yongqi Fan, Chao Zhang, Lei Sun, Tingting Ye, Qiushuang Wang, Youhao Ban, Yunxia Cao, Huijuan Zou, Zhiguo Zhang   +12 more
doaj   +1 more source