Results 61 to 70 of about 1,269 (186)

Alarmins link neutrophils and dendritic cells [PDF]

Trends in Immunology, 2009
Neutrophils are the first major population of leukocyte to infiltrate infected or injured tissues and are crucial for initiating host innate defense and adaptive immunity. Although the contribution of neutrophils to innate immune defense is mediated predominantly by phagocytosis and killing of microorganisms, neutrophils also participate in the ...
De, Yang, Gonzalo, de la Rosa, Poonam, Tewary, Joost J, Oppenheim   +3 more
openaire   +2 more sources

PTX3 Predicts Myocardial Damage and Fibrosis in Duchenne Muscular Dystrophy

Frontiers in Physiology, 2020
Pentraxin 3 (PTX3) is a main component of the innate immune system by inducing complement pathway activation, acting as an inflammatory mediator, coordinating the functions of macrophages/dendritic cells and promoting apoptosis/necrosis. Additionally, it
Andrea Farini, Chiara Villa, Dario Di Silvestre, Pamela Bella, Luana Tripodi, Rossana Rossi, Clementina Sitzia, Stefano Gatti, Pierluigi Mauri, Yvan Torrente   +9 more
doaj   +1 more source

Vitamin D analogs differentially control antimicrobial peptide/"alarmin" expression in psoriasis [PDF]

, 2009
Antimicrobial peptides (AMPs) are strongly expressed in lesional skin in psoriasis and play an important role as proinflammatory "alarmins" in this chronic skin disease.
Koglin, Sarah, Ulrich Zügel, Thomas Ruzicka, Büchau Amanda, Dombrowski, Yvonne, Zügel, Ulrich, Steinmeyer, Andreas, Jürgen Schauber, Schauber, Jürgen, Büchau, Amanda, Sarah Koglin, Steinmeyer Andreas, Bradac, Eva, Mark Peric, Schauber Jürgen, Koglin Sarah, Amanda Büchau, Zügel Ulrich, Yvonne Dombrowski, Eva Bradac, Katrin Gross, Peric Mark, Gross, Katrin, Dombrowski Yvonne, Peric, Mark, Andreas Steinmeyer, Dombrowski, Yvonne; id_orcid, Bradac Eva, Groß Katrin, Ruzicka, Thomas, Ruzicka Thomas   +30 more
core   +1 more source

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source

Mitochondrial Damage-Associated Molecular Patterns: From Inflammatory Signaling to Human Diseases

Frontiers in Immunology, 2018
Over the recent years, much has been unraveled about the pro-inflammatory properties of various mitochondrial molecules once they are leaving the mitochondrial compartment.
Serge Grazioli, Serge Grazioli, Jérôme Pugin   +2 more
doaj   +1 more source

Exercise‐specific plasma proteomic signatures in racehorses: Candidates for training adaptation and peak load monitoring

Equine Veterinary Journal, EarlyView.
Abstract Background Racehorses undergo profound physiological changes with training and competition, but current biomarkers inadequately capture the complex molecular dynamics of exercise. This study aimed to identify novel plasma biomarkers of training adaptation and peak load using high‐throughput proteomics.
Jowita Grzędzicka, Bianka Świderska, Ewa Sitkiewicz, Izabela Dąbrowska, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Brain-released alarmins and stress response synergize in accelerating atherosclerosis progression after stroke.

, 2018
Stroke induces a multiphasic systemic immune response, but the consequences of this response on atherosclerosis-a major source of recurrent vascular events-have not been thoroughly investigated.
Singh, Vikramjeet, Huber, G., Stefan Roth, Gauberti, M., Bianchi, Marco E., Gauberti, Maxime, Helena Erlandsson Harris, Antoine Anfray, Georg Huber, Tiedt, Steffen, Maxime Gauberti, Huber, Georg, Daniel J. Antoine, Holdt, Lesca M., Orset, C., Bernhagen, Jürgen, Christof Haffner, Engelhardt, Britta, Harris, H.E., Britta Engelhardt, Antoine, Daniel J., Martin Dichgans, Marco E. Bianchi, Bianchi, M.E., Vivien, D., Roth, Stefan, Schindler, L., Holdt, L.M., Engelhardt, B., Cyrille Orset, Bianchi, Marco E, Fournier, A., Geerlof, Arie, Fournier, Antoine, Orset, Cyrille, Geerlof, A., Bernhagen, J., Vivien, Denis, Lesca M. Holdt, Liesz, A., Schindler, Lisa, Anfray, A., Harris, Helena Erlandsson, Liesz, Arthur, Denis Vivien, Steffen Tiedt, Jürgen Bernhagen, Holdt, Lesca M, Vikramjeet Singh, Arthur Liesz, Haffner, C., Singh, V.K., Antoine Fournier, Antoine, D.J., Anfray, Antoine, Antoine, Daniel J, Dichgans, Martin, Tiedt, S., Haffner, Christof, Lisa Schindler, Roth, S., Arie Geerlof, Dichgans, M.   +62 more
core   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

The Multitasking Potential of Alarmins and Atypical Chemokines [PDF]

Frontiers in Medicine, 2019
When the human genome was sequenced, it came as a surprise that it contains "only" 21,306 protein-coding genes. However, complexity and diversity are multiplied by alternative splicing, non-protein-coding transcripts, or post-translational modifications (PTMs) on proteome level.
Aphrodite Kapurniotu, Ozgun Gokce, Jürgen Bernhagen, Jürgen Bernhagen, Jürgen Bernhagen   +4 more
openaire   +4 more sources

Targeting Inflammatory Alarmin S100A9 Modulates Activation of Pro‐Inflammatory Macrophage to Protect Nasal Epithelial Cells From LPS‐Induced Epithelial–Mesenchymal Transition

Microbiology and Immunology, EarlyView.
ABSTRACT Chronic rhinosinusitis with nasal polyps (CRSwNP) exhibits pronounced endotypic heterogeneity, with macrophages serving as key drivers of sustained mucosal inflammation. In this study, we identify S100A9 as a macrophage‐derived alarmin that is markedly elevated in CRSwNP tissues.
Yunxiang Ji, Jia Luan, Fang Yuan, Zhao Wang, Ran Wei, Guangbin Sun   +5 more
wiley   +1 more source