Results 51 to 60 of about 9,358 (229)
Novel Biological Therapies for Severe Asthma Endotypes
Biomedicines, 2022 Severe asthma comprises several heterogeneous phenotypes, underpinned by complex pathomechanisms known as endotypes. The latter are driven by intercellular networks mediated by molecular components which can be targeted by specific monoclonal antibodies.
Corrado Pelaia +8 more
doaj +1 more source
Prothymosin Alpha: An Alarmin and More...
Current Medicinal Chemistry, 2017 Prothymosin alpha (proTα) is a ubiquitous polypeptide first isolated by Haritos in 1984, whose role still remains partly elusive. We know that proTα acts both, intracellularly, as an anti-apoptotic and proliferation mediator, and extracellularly, as a biologic response modifier mediating immune responses similarly to molecules termed as "alarmins". Our
Samara, P. +11 more
openaire +3 more sources
Advanced Science, EarlyView.Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...
Zhuojin Li +8 more
wiley +1 more source
Frontiers in Immunology, 2021 Nowadays, in the study of rheumatoid arthritis (RA), more and more interest is directed towards an earlier effective therapeutic intervention and the determination of companion markers for predicting response to therapy with the goal to prevent ...
Federica Ciregia +10 more
doaj +1 more source
Matrix Stiffness Induces Endothelial Network Senescence
Advanced Science, EarlyView.Using a 3D human in vitro model that decouples mechanical stress from inflammatory or biochemical signals, matrix stiffening induces a senescence phenotype in endothelial networks. This mechano‐induced senescence activates Notch signaling, and pharmacologic Notch inhibition attenuates this stiffness‐induced senescence.
Jiyeon Song +6 more
wiley +1 more source
Role of alarmins in perioperative medicine. [PDF]
, 2018 Introduction: Inflammatory response (IR) is a fundamental reaction to the cell and tissue injury. It is aimed at correcting the pathologic condition and maintaining the structural and functional integrity of the organism. The insult with too extensive or
Máca, Jan
core
Cardiac Alarmins as Residual Risk Markers of Atherosclerosis under Hypolipidemic Therapy [PDF]
, 2022 Increased levels of low-density lipoproteins are the main risk factor in the initiation and progression of atherosclerosis. Although statin treatment can effectively lower these levels, there is still a residual risk of cardiovascular events.
Antohe, Felicia +13 more
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International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Background Chronic rhinosinusitis (CRS) and allergic rhinitis (AR) are two highly prevalent airway diseases in the United States. While the coexistence of CRS and asthma is well recognized, less is known about the development of new‐onset asthma in CRS, particularly in the context of comorbid AR. This study assessed the impact of CRS and AR on
Austin J. Lee, Mohamad R. Chaaban
wiley +1 more source
HMGB1, IL-1alpha, IL-33 and S100 proteins: dual-function alarmins [PDF]
, 2017 Our immune system is based on the close collaboration of the innate and adaptive immune systems for the rapid detection of any threats to the host. Recognition of pathogen-derived molecules is entrusted to specific germline-encoded signaling receptors ...
Bertheloot, Damien, Latz, Eicke
core +2 more sources
European Journal of Medical ResearchAlarmins are a class of molecules released when affected cells damaged or undergo apoptosis. They contain various chemotactic and immunomodulatory proteins or peptides.
Qiqi Zhang +12 more
doaj +1 more source