Results 1 to 10 of about 1,716 (68)

Airway Epithelium: A Neglected but Crucial Cell Type in Asthma Pathobiology

Diagnostics, 2023
The features of allergic asthma are believed to be mediated mostly through the Th2 immune response. In this Th2-dominant concept, the airway epithelium is presented as the helpless victim of Th2 cytokines. However, this Th2-dominant concept is inadequate
Ulaganathan Mabalirajan, Joytri Dutta, Sabita Singh   +2 more
exaly   +3 more sources

Canonical WNT Pathway Is Activated in the Airway Epithelium in Chronic Obstructive Pulmonary Disease

EBioMedicine, 2020
Background: Chronic obstructive pulmonary disease (COPD) is a devastating lung disease, mainly due to cigarette smoking, which represents the third cause of mortality worldwide.
François M Carlier, Charles Pilette, Sophie Gohy   +2 more
exaly   +3 more sources

Allicin Facilitates Airway Surface Liquid Hydration by Activation of CFTR

Frontiers in Pharmacology, 2022
Airway epithelium plays critical roles in regulating airway surface liquid (ASL), the alteration of which causes mucus stasis symptoms. Allicin is a compound released from garlic and harbors the capacity of lung-protection.
Zhuo-Er Qiu, Jian-Bang Xu, Jian-Bang Xu, Lei Chen, Ze-Xin Huang, Tian-Lun Lei, Zi-Yang Huang, Xiao-Chun Hou, Hai-Long Yang, Qin-Hua Lin, Yun-Xin Zhu, Lei Zhao, Lei Zhao, Wen-Liang Zhou, Yi-Lin Zhang   +14 more
doaj   +1 more source

The human airway epithelial basal cell transcriptome. [PDF]

PLoS ONE, 2011
The human airway epithelium consists of 4 major cell types: ciliated, secretory, columnar and basal cells. During natural turnover and in response to injury, the airway basal cells function as stem/progenitor cells for the other airway cell types.
Neil R Hackett, Renat Shaykhiev, Matthew S Walters, Rui Wang, Rachel K Zwick, Barbara Ferris, Bradley Witover, Jacqueline Salit, Ronald G Crystal   +8 more
doaj   +1 more source

Opto-electromechanical quantification of epithelial barrier function in injured and healthy airway tissues

APL Bioengineering, 2023
The airway epithelium lining the luminal surface of the respiratory tract creates a protective barrier that ensures maintenance of tissue homeostasis and prevention of respiratory diseases.
Jiawen Chen, Seyed Mohammad Mir, Maria R. Hudock, Meghan R. Pinezich, Panpan Chen, Matthew Bacchetta, Gordana Vunjak-Novakovic, Jinho Kim   +7 more
doaj   +1 more source

Airway epithelial cell-specific deletion of HMGB1 exaggerates inflammatory responses in mice with muco-obstructive airway disease

Frontiers in Immunology, 2023
High mobility group box 1 (HMGB1), a ubiquitous chromatin-binding protein required for gene transcription regulation, is released into the extracellular microenvironment by various structural and immune cells, where it is known to act as an alarmin. Here,
Yun Mao, Sonika Patial, Yogesh Saini
doaj   +1 more source

Conserved Mechanisms in the Formation of the Airways and Alveoli of the Lung

Frontiers in Cell and Developmental Biology, 2021
Branching is an intrinsic property of respiratory epithelium that can be induced and modified by signals emerging from the mesenchyme. However, during stereotypic branching morphogenesis of the airway, the relatively thick upper respiratory epithelium ...
David Warburton
doaj   +1 more source

Apical-Out Human Airway Organoids Modeling SARS-CoV-2 Infection

Viruses, 2023
The respiratory epithelium, particularly the airway epithelium, is the primary infection site for respiratory pathogens. The apical surface of epithelial cells is constantly exposed to external stimuli including invading pathogens. Efforts have been made
Man Chun Chiu, Shuxin Zhang, Cun Li, Xiaojuan Liu, Yifei Yu, Jingjing Huang, Zhixin Wan, Xiaoxin Zhu, Jie Zhou   +8 more
doaj   +1 more source

Establishing Bipotential Human Lung Organoid Culture System and Differentiation to Generate Mature Alveolar and Airway Organoids

Bio-Protocol, 2023
A robust in vitro model of the human respiratory epithelium, including the alveolar and the airway epithelium, is essential for understanding the biology and pathology of the human respiratory system.
Man Chun Chiu, Cun Li, Yifei Yu, Xiaojuan Liu, Jingjing Huang, Zhixin Wan, Kwok Yung Yuen, Jie Zhou   +7 more
doaj   +1 more source

Fibroblast growth factor-9 expression in airway epithelial cells amplifies the type I interferon response and alters influenza A virus pathogenesis.

PLoS Pathogens, 2022
Influenza A virus (IAV) preferentially infects conducting airway and alveolar epithelial cells in the lung. The outcome of these infections is impacted by the host response, including the production of various cytokines, chemokines, and growth factors ...
Bradley E Hiller, Yongjun Yin, Yi-Chieh Perng, Ítalo de Araujo Castro, Lindsey E Fox, Marissa C Locke, Kristen J Monte, Carolina B López, David M Ornitz, Deborah J Lenschow   +9 more
doaj   +1 more source