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Airway Epithelium: A Neglected but Crucial Cell Type in Asthma Pathobiology
Diagnostics, 2023 The features of allergic asthma are believed to be mediated mostly through the Th2 immune response. In this Th2-dominant concept, the airway epithelium is presented as the helpless victim of Th2 cytokines. However, this Th2-dominant concept is inadequate
Ulaganathan Mabalirajan +2 more
exaly +3 more sources
Canonical WNT pathway is activated in the airway epithelium in chronic obstructive pulmonary disease
EBioMedicine, 2020 Background: Chronic obstructive pulmonary disease (COPD) is a devastating lung disease, mainly due to cigarette smoking, which represents the third cause of mortality worldwide.
François Carlier +2 more
exaly +3 more sources
Influence of Hypoxia on the Airway Epithelium. [PDF]
Physiol ResThe necessity of oxygen for metabolic processes means that hypoxia can lead to serious cell and tissue damage. On the other hand, in some situations, hypoxia occurs under physiological conditions and serves as an important regulation factor. The airway epithelium is specific in that it gains oxygen not only from the blood supply but also directly from ...
Procházková K, Uhlík J.
europepmc +3 more sources
Barrier function of airway tract epithelium [PDF]
Tissue Barriers, 2013 Airway epithelium contributes significantly to the barrier function of airway tract. Mucociliary escalator, intercellular apical junctional complexes which regulate paracellular permeability and antimicrobial peptides secreted by the airway epithelial cells are the three primary components of barrier function of airway tract. These three components act
Shyamala Ganesan, Adam T Comstock
exaly +3 more sources
Airway epithelium in lung transplantation: a potential actor for post-transplant complications? [PDF]
European Respiratory ReviewLung transplantation, a critical intervention for end-stage lung diseases, is frequently challenged by post-transplant complications. Indeed, primary graft dysfunction, anastomotic complications, infections and acute and chronic rejections pose ...
Jules Milesi +3 more
doaj +2 more sources
Allicin Facilitates Airway Surface Liquid Hydration by Activation of CFTR
Frontiers in Pharmacology, 2022 Airway epithelium plays critical roles in regulating airway surface liquid (ASL), the alteration of which causes mucus stasis symptoms. Allicin is a compound released from garlic and harbors the capacity of lung-protection.
Zhuo-Er Qiu +14 more
doaj +1 more source
Engineering Airway Epithelium [PDF]
Journal of Biomedicine and Biotechnology, 2012 Airway epithelium is constantly presented with injurious signals, yet under healthy circumstances, the epithelium maintains its innate immune barrier and mucociliary elevator function. This suggests that airway epithelium has regenerative potential (I. R. Telford and C. F. Bridgman, 1990).
John P. Soleas +4 more
openaire +4 more sources
The human airway epithelial basal cell transcriptome. [PDF]
PLoS ONE, 2011 The human airway epithelium consists of 4 major cell types: ciliated, secretory, columnar and basal cells. During natural turnover and in response to injury, the airway basal cells function as stem/progenitor cells for the other airway cell types.
Neil R Hackett +8 more
doaj +1 more source
APL Bioengineering, 2023 The airway epithelium lining the luminal surface of the respiratory tract creates a protective barrier that ensures maintenance of tissue homeostasis and prevention of respiratory diseases.
Jiawen Chen +7 more
doaj +1 more source
Function of the airway epithelium in asthma. [PDF]
Journal of biological regulators and homeostatic agents, 2012 Asthma is traditionally defined as a chronic disease characterized by bronchial hyper-responsiveness and lung inflammation. The airway inflammation and remodelling together likely explain the clinical manifestations of asthma. The mechanisms by which the external environmental cues, together with the complex genetic actions, propagate the inflammatory ...
LEONARDI, SALVATORE +9 more
openaire +8 more sources