Results 31 to 40 of about 67,377 (251)

Lung epithelium development and airway regeneration

Frontiers in Cell and Developmental Biology, 2022
The lung is composed of a highly branched airway structure, which humidifies and warms the inhaled air before entering the alveolar compartment. In the alveoli, a thin layer of epithelium is in close proximity with the capillary endothelium, allowing for an efficient exchange of oxygen and carbon dioxide.
Evelien Eenjes, Dick Tibboel, Rene M.H. Wijnen, Robbert J. Rottier, Robbert J. Rottier   +4 more
openaire   +3 more sources

Validation of the Human Ozone Challenge Model as a Tool for Assessing Anti-Inflammatory Drugs in Early Development [PDF]

, 2005
This study aimed to test the utility of the ozone challenge model for profiling novel compounds designed to reduce airway inflammation. The authors used a randomized, doubledummy, double-blind, placebo-controlled 3-period crossover design alternating ...
Vessey, Rupert S. J., Holz, Olaf, Rudolf A. Jörres, Kai Richter, Simpson, Kathy J., Tal-Singer, Ruth, Helgo Magnussen, Magnussen, Helgo, Anthony Gibson, Stanislawa Janicki, Kanniess, Frank, Richter, Kai, Ruth Tal-Singer, Gibson, Anthony, Kathy J. Simpson, Frank Kanniess, Janicki, Stanislawa, Rupert S. J. Vessey, Jörres, Rudolf A., Olaf Holz   +19 more
core   +1 more source

Surprises from the airway epithelium [PDF]

Proceedings of the National Academy of Sciences, 2001
The epithelium of the pulmonary airways subserves a wide range of functions, from providing a barrier against inhaled particles and pathogens to transmitting signals to subepithelial cells. Given the central place of the epithelium in respiratory tract pathophysiology, the molecular determinants of epithelial function are appropriately the focus of ...
openaire   +2 more sources

Elevated Paracellular Glucose Flux across Cystic Fibrosis Airway Epithelial Monolayers Is an Important Factor for Pseudomonas aeruginosa Growth.

, 2013
People with cystic fibrosis (CF) who develop related diabetes (CFRD) have accelerated pulmonary decline, increased infection with antibiotic-resistant Pseudomonas aeruginosa and increased pulmonary exacerbations.
James P Garnett, Tarran Robert, Ward, Christopher, Ward Christopher, Michael A Gray, Baines, DL, Garnett, James P., Robert Tarran, Christopher Ward, Ward, C, Garnett, JP, Baker, EH, Brodlie Malcolm, Baker, Emma H., Tarran, Robert, Gray Michael A., Brodlie, Malcolm, Baker Emma H., Garnett James P., Brodlie, M, Deborah L Baines, Baines Deborah L., Gray, Michael A., Baines, Deborah L., Gray, MA, Malcolm Brodlie, Tarran, R, Emma H Baker   +27 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Effects of Oxidative Stress on Airway Epithelium Permeability in Asthma and Potential Implications for Patients with Comorbid Obesity

, 2023
Haein R Kim, Jennifer L Ingram, Loretta G Que Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University Medical Center, Durham, NC, USACorrespondence: Haein R Kim, Division of Pulmonary, Allergy and Critical Care Medicine, Duke ...
Que LG, Kim HR, Ingram JL
core  

A Novel Decellularized Fibrocartilage Graft Promotes Tympanic Membrane Repair

Advanced Healthcare Materials, EarlyView.
An off‐the‐shelf decellularized porcine meniscus fibrocartilage graft (MEND) is engineered for pediatric tympanoplasty. Featuring a microchannel architecture that promotes host cell invasion, MEND rapidly closes tympanic membrane perforations and fully remodels in vivo, outperforming fascia and matching cartilage grafts while avoiding donor‐site ...
Paul M. Gehret, Ryan M. Friedman, Gautham Nair, Stephanie L. Fung, Dana D. Ragbirsingh, John Germiller, Riccardo Gottardi   +6 more
wiley   +1 more source

Functional Precision Oncology Approach Using Nanoliter Droplet Array for Drug Sensitivity Testing in Lung Cancer

Advanced Healthcare Materials, EarlyView.
A miniaturized drug sensitivity and resistance testing (DSRT) workflow based on the Droplet Microarray (DMA) platform enables functional drug testing using minimal patient‐derived tumor material. By screening nanoliter‐scale droplets containing as few as 300 cells, this approach generates reproducible and tumor‐specific drug response profiles ...
Maryam Salarian, Vicky L. Schiling, Thomas Muley, Michael Allgäuer, Florian Eichhorn, Michael Meister, Marc A. Schneider, Anna A. Popova   +7 more
wiley   +1 more source