Results 31 to 40 of about 62,023 (261)

SOX21 modulates SOX2-initiated differentiation of epithelial cells in the extrapulmonary airways

eLife, 2021
SOX2 expression levels are crucial for the balance between maintenance and differentiation of airway progenitor cells during development and regeneration. Here, we describe patterning of the mouse proximal airway epithelium by SOX21, which coincides with
Evelien Eenjes, Marjon Buscop-van Kempen, Anne Boerema-de Munck, Gabriela G Edel, Floor Benthem, Lisette de Kreij-de Bruin, Marco Schnater, Dick Tibboel, Jennifer Collins, Robbert J Rottier   +9 more
doaj   +1 more source

A bipotential organoid model of respiratory epithelium recapitulates high infectivity of SARS-CoV-2 Omicron variant

Cell Discovery, 2022
The airways and alveoli of the human respiratory tract are lined by two distinct types of epithelium, which are the primary targets of respiratory viruses.
Man Chun Chiu, Cun Li, Xiaojuan Liu, Yifei Yu, Jingjing Huang, Zhixin Wan, Ding Xiao, Hin Chu, Jian-Piao Cai, Biao Zhou, Ko-Yung Sit, Wing-Kuk Au, Kenneth Kak-Yuen Wong, Gang Li, Jasper Fuk-Woo Chan, Kelvin Kai-Wang To, Zhiwei Chen, Shibo Jiang, Hans Clevers, Kwok Yung Yuen, Jie Zhou   +20 more
doaj   +1 more source

Lung epithelium development and airway regeneration

Frontiers in Cell and Developmental Biology, 2022
The lung is composed of a highly branched airway structure, which humidifies and warms the inhaled air before entering the alveolar compartment. In the alveoli, a thin layer of epithelium is in close proximity with the capillary endothelium, allowing for an efficient exchange of oxygen and carbon dioxide.
Evelien Eenjes, Dick Tibboel, Rene M.H. Wijnen, Robbert J. Rottier, Robbert J. Rottier   +4 more
openaire   +3 more sources

Surprises from the airway epithelium [PDF]

Proceedings of the National Academy of Sciences, 2001
The epithelium of the pulmonary airways subserves a wide range of functions, from providing a barrier against inhaled particles and pathogens to transmitting signals to subepithelial cells. Given the central place of the epithelium in respiratory tract pathophysiology, the molecular determinants of epithelial function are appropriately the focus of ...
openaire   +2 more sources

The Dual Role of the Airway Epithelium in Asthma: Active Barrier and Regulator of Inflammation

Cells, 2023
Chronic airway inflammation is the cornerstone on which bronchial asthma arises, and in turn, chronic inflammation arises from a complex interplay between environmental factors such as allergens and pathogens and immune cells as well as structural cells ...
Andreas Frey, Lars P. Lunding, Michael Wegmann   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Paracrine signaling of ferroptotic airway epithelium in crystalline silica-induced pulmonary fibrosis augments local fibroblast activation through glycolysis reprogramming

Ecotoxicology and Environmental Safety
Chronic exposure to crystalline silica (CS) contributes to pulmonary fibrosis. Airway epithelium dysfunction and fibroblast activation have both been recognized as pivotal players, alongside disturbances in ferroptosis and glycolysis reprogramming ...
Qianmin Li, Yi Ling, Yu Ma, Tao Zhang, Youjing Yang, Shasha Tao   +5 more
doaj   +1 more source

Expression of ICAM-1 on human bronchial epithelial cells after influenza virus infection

Allergology International, 1996
Damage of bronchial epithelium is a feature of airway viral infection and airway inflammatory disease, such as bronchial asthma. Adhesion molecules, which are expressed on bronchial epithelium, play an important role in the pathogenesis of epithelial ...
Satoshi Matsukura, Fumio Kokubu, Hiromichi Noda, Hiroyuki Watanabe, Kunihiko Fukuchi, Kunio Gomi, Mitsuru Adachi   +6 more
doaj   +1 more source

In vivo disruption of TGF-beta signaling by Smad7 in airway epithelium alleviates allergic asthma but aggravates lung carcinogenesis in mouse. [PDF]

PLoS ONE, 2010
BACKGROUND: TGF-beta has been postulated to play an important role in the maintenance of epithelial homeostasis and the development of epithelium-derived cancers.
Xiaolin Luo, Qiurong Ding, Min Wang, Zhigang Li, Kairui Mao, Bing Sun, Yi Pan, Zhenzhen Wang, Ying Qin Zang, Yan Chen   +9 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source