Results 21 to 30 of about 62,023 (261)
Cells, 2022 Airway epithelial cells represent the main target of SARS-CoV-2 replication but several pieces of evidence suggest that endothelial cells (ECs), lining pulmonary blood vessels, are key players in lung injury in COVID-19 patients.
Veronica Bordoni +6 more
doaj +1 more source
Медицинская иммунология, 2023 Daily inhaled antigens induce cellular immune response in the airways. In case of allergens, allergic airway inflammation is usually represented by eosinophils, however, neutrophil infiltration is also observed during severe asthma.
M. A. Shevchenko +2 more
doaj +1 more source
Rhinovirus and COPD airway epithelium [PDF]
Pulmonary and Critical Care Medicine, 2017 Chronic Obstructive Pulmonary Disease (COPD) is characterized by irreversible airflow limitation. It is a global disease and expected to be the third leading cause of death. Respiratory exacerbations are associated with increased mortality and morbidity in this patient population.
Nicole, Owuor +3 more
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Smoking-mediated up-regulation of GAD67 expression in the human airway epithelium
Respiratory Research, 2010 Background The production of gamma-amino butyric acid (GABA) is dependent on glutamate decarboxylases (GAD65 and GAD67), the enzymes that catalyze the decarboxylation of glutamate to GABA.
Strulovici-Barel Yael +6 more
doaj +1 more source
Cell-intrinsic differences between human airway epithelial cells from children and adults
iScience, 2022 Summary: The airway epithelium is a protective barrier that is maintained by the self-renewal and differentiation of basal stem cells. Increasing age is a principle risk factor for chronic lung diseases, but few studies have explored age-related ...
Elizabeth F. Maughan +25 more
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Role of airway epithelial barrier dysfunction in pathogenesis of asthma
Allergology International, 2018 Bronchial asthma is characterized by persistent cough, increased sputum, and repeated wheezing. The pathophysiology underlying these symptoms is the hyper-responsiveness of the airway along with chronic airway inflammation.
Yasuhiro Gon, Shu Hashimoto
doaj +1 more source
Death at the airway epithelium in asthma [PDF]
Cell Research, 2013 Allergic asthma is an inflammatory disease of the airways in which epithelial cells, dendritic cells and innate lymphoid cells are increasingly implicated. Recent findings suggest that apoptotic cells are phagocytosed by airway epithelial cells in a Rac1-dependent manner and this leads to dampening of innate and adaptive immunity to allergens.
Bart N Lambrecht, Hamida Hammad
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Respiratory Research, 2019 Background Chronic obstructive pulmonary disease (COPD) is a common respiratory disease with high morbidity and mortality. The most important pathophysiological change of COPD is airway obstruction.
Yidan Ren +5 more
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Genes associated with MUC5AC expression in small airway epithelium of human smokers and non-smokers
BMC Medical Genomics, 2012 Background Mucus hypersecretion contributes to the morbidity and mortality of smoking-related lung diseases, especially chronic obstructive pulmonary disease (COPD), which starts in the small airways.
Wang Guoqing +8 more
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GemC1 controls multiciliogenesis in the airway epithelium [PDF]
The EMBO Reports, 2016 Multiciliated cells are terminally differentiated, post-mitotic cells that form hundreds of motile cilia on their apical surface. Defects in multiciliated cells lead to disease, including mucociliary clearance disorders that result from ciliated cell disfunction in airways.
Marina Arbi +7 more
openaire +2 more sources