Results 21 to 30 of about 375,726 (199)

Metformin reduces airway glucose permeability and hyperglycaemia-induced Staphylococcus aureus load independently of effects on blood glucose [PDF]

, 2013
Background Diabetes is a risk factor for respiratory infection, and hyperglycaemia is associated with increased glucose in airway surface liquid and risk of Staphylococcus aureus infection.
Garnett, James P, Tregoning, John S, Baines, DL, Baines, Deborah L, Knight, Gwenan M, Naik, S, Lindsay, JA, Tregoning, JS, Naik, Sonam, Garnett, JP, Baker, EH, Lindsay, Jodi A, Gill, S, Baker, Emma H, Gill, Simren, Knight, GM   +15 more
core   +1 more source

Smoking-mediated up-regulation of GAD67 expression in the human airway epithelium

Respiratory Research, 2010
Background The production of gamma-amino butyric acid (GABA) is dependent on glutamate decarboxylases (GAD65 and GAD67), the enzymes that catalyze the decarboxylation of glutamate to GABA.
Strulovici-Barel Yael, Salit Jacqueline, Ferris Barbara, Wang Rui, Wang Guoqing, Hackett Neil R, Crystal Ronald G   +6 more
doaj   +1 more source

SARS-CoV-2 Infection of Airway Epithelium Triggers Pulmonary Endothelial Cell Activation and Senescence Associated with Type I IFN Production

Cells, 2022
Airway epithelial cells represent the main target of SARS-CoV-2 replication but several pieces of evidence suggest that endothelial cells (ECs), lining pulmonary blood vessels, are key players in lung injury in COVID-19 patients.
Veronica Bordoni, Davide Mariotti, Giulia Matusali, Francesca Colavita, Eleonora Cimini, Giuseppe Ippolito, Chiara Agrati   +6 more
doaj   +1 more source

Effect of terbutaline on hyperpnoea-induced bronchoconstriction and urinary club cell protein 16 in athletes [PDF]

, 2013
This article is made available through the Brunel Open Access Publishing Fund and is distributed by the Creative Commons CC-BY 3.0 license, under which all are free to reuse or distribute the article under the condition that this original publication ...
Romer, L. M., Simpson, Andrew, L. Bjermer, P. Kippelen, A. J. Simpson, L. M. Romer, Bjermer, Leif, Romer, L M., Simpson, AJ, Tufvesson, E, Anderson, S. D., Simpson, A. J., S. D. Anderson, Bjermer, L, Tufvesson, Ellen, Kippelen, P, Tufvesson, E., Romer, LM, Bjermer, L., Anderson, SD, Kippelen, P., E. Tufvesson, Bjermer, Leif,, Tufvesson, Ellen,, Lund University.   +24 more
core   +1 more source

Role of airway epithelial barrier dysfunction in pathogenesis of asthma

Allergology International, 2018
Bronchial asthma is characterized by persistent cough, increased sputum, and repeated wheezing. The pathophysiology underlying these symptoms is the hyper-responsiveness of the airway along with chronic airway inflammation.
Yasuhiro Gon, Shu Hashimoto
doaj   +1 more source

Cell-intrinsic differences between human airway epithelial cells from children and adults

iScience, 2022
Summary: The airway epithelium is a protective barrier that is maintained by the self-renewal and differentiation of basal stem cells. Increasing age is a principle risk factor for chronic lung diseases, but few studies have explored age-related ...
Elizabeth F. Maughan, Robert E. Hynds, Adam Pennycuick, Ersilia Nigro, Kate H.C. Gowers, Celine Denais, Sandra Gómez-López, Kyren A. Lazarus, Jessica C. Orr, David R. Pearce, Sarah E. Clarke, Dani Do Hyang Lee, Maximillian N.J. Woodall, Tereza Masonou, Katie-Marie Case, Vitor H. Teixeira, Benjamin E. Hartley, Richard J. Hewitt, Chadwan Al Yaghchi, Gurpreet S. Sandhu, Martin A. Birchall, Christopher O’Callaghan, Claire M. Smith, Paolo De Coppi, Colin R. Butler, Sam M. Janes   +25 more
doaj   +1 more source

Elevated Paracellular Glucose Flux across Cystic Fibrosis Airway Epithelial Monolayers Is an Important Factor for Pseudomonas aeruginosa Growth. [PDF]

, 2013
People with cystic fibrosis (CF) who develop related diabetes (CFRD) have accelerated pulmonary decline, increased infection with antibiotic-resistant Pseudomonas aeruginosa and increased pulmonary exacerbations.
James P Garnett, Tarran Robert, Ward, Christopher, Ward Christopher, Michael A Gray, Baines, DL, Garnett, James P., Robert Tarran, Christopher Ward, Ward, C, Garnett, JP, Baker, EH, Brodlie Malcolm, Baker, Emma H., Tarran, Robert, Gray Michael A., Brodlie, Malcolm, Baker Emma H., Garnett James P., Brodlie, M, Deborah L Baines, Baines Deborah L., Gray, Michael A., Baines, Deborah L., Gray, MA, Malcolm Brodlie, Tarran, R, Emma H Baker   +27 more
core   +1 more source

Genes associated with MUC5AC expression in small airway epithelium of human smokers and non-smokers

BMC Medical Genomics, 2012
Background Mucus hypersecretion contributes to the morbidity and mortality of smoking-related lung diseases, especially chronic obstructive pulmonary disease (COPD), which starts in the small airways.
Wang Guoqing, Xu Zhibo, Wang Rui, Al-Hijji Mohammed, Salit Jacqueline, Strulovici-Barel Yael, Tilley Ann E, Mezey Jason G, Crystal Ronald G   +8 more
doaj   +1 more source

Spatial characteristics of neutrophils and eosinophils in conducting airway mucosa of mice with induced allergic airway inflammation

Медицинская иммунология, 2023
Daily inhaled antigens induce cellular immune response in the airways. In case of allergens, allergic airway inflammation is usually represented by eosinophils, however, neutrophil infiltration is also observed during severe asthma.
M. A. Shevchenko, D. E. Murova, E. A. Servuli   +2 more
doaj   +1 more source

The cullin4A is up-regulated in chronic obstructive pulmonary disease patient and contributes to epithelial-mesenchymal transition in small airway epithelium

Respiratory Research, 2019
Background Chronic obstructive pulmonary disease (COPD) is a common respiratory disease with high morbidity and mortality. The most important pathophysiological change of COPD is airway obstruction.
Yidan Ren, Yi Zhang, Lixia Fan, Qinlian Jiao, Yunshan Wang, Qin Wang   +5 more
doaj   +1 more source