Results 11 to 20 of about 375,726 (199)

Human airway xenograft models of epithelial cell regeneration [PDF]

Respiratory Research, 2000
Regeneration and restoration of the airway epithelium after mechanical, viral or bacterial injury have a determinant role in the evolution of numerous respiratory diseases such as chronic bronchitis, asthma and cystic fibrosis.
Puchelle Edith, Peault Bruno
doaj   +2 more sources

Disparate oxidant gene expression of airway epithelium compared to alveolar macrophages in smokers

Respiratory Research, 2009
Background The small airway epithelium and alveolar macrophages are exposed to oxidants in cigarette smoke leading to epithelial dysfunction and macrophage activation. In this context, we asked: what is the transcriptome of oxidant-related genes in small
Hackett Neil R, Harvey Ben-Gary, Carolan Brendan J, O'Connor Timothy P, Cassano Patricia A, Crystal Ronald G   +5 more
doaj   +2 more sources

In vivo models of human airway epithelium repair and regeneration

European Respiratory Review, 2005
Despite an efficient defence system, the airway surface epithelium, in permanent contact with the external milieu, is frequently injured by inhaled pollutants, microorganisms and viruses.
C. Coraux, R. Hajj, P. Lesimple, E. Puchelle   +3 more
doaj   +1 more source

Targeting TSLP With shRNA Alleviates Airway Inflammation and Decreases Epithelial CCL17 in a Murine Model of Asthma

Molecular Therapy: Nucleic Acids, 2016
Airway epithelium defends the invasion from microorganisms and regulates immune responses in allergic asthma. Thymic stromal lymphopoietin (TSLP) from inflamed epithelium promotes maturation of dendritic cells (DCs) to prime Th2 responses via CCL17 ...
Yi-Lien Chen, Bor-Luen Chiang
doaj   +2 more sources

Pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional

Nature Communications, 2021
Environmental and genetic risk factors affect the distal airway epithelium in idiopatic pulmonary fibrosis (IPF) but the role of the epithelium in IPF remains unclear.
Ian T. Stancil, Jacob E. Michalski, Duncan Davis-Hall, Hong Wei Chu, Jin-Ah Park, Chelsea M. Magin, Ivana V. Yang, Bradford J. Smith, Evgenia Dobrinskikh, David A. Schwartz   +9 more
doaj   +1 more source

Direct in vivo gene transfer to the airway epithelium employing adenovirus-polylysine-DNA complexes [PDF]

, 1993
Adenovirus-polylysine-DNA complexes were evaluated for their capacity to accomplish direct in vivo gene transfer to airway epithelium employing a rodent model.
Miller, L., Rømer, M., Wagner, E., Harris, C. E., Hu, P.-C., Wagner, Ernst, Cotten, Matt, Cotten, M., Agarwal, Santosh, Curiel, David T., Agarwal, S., Gao, L., Harris, C., Romer, M., Curiel, D.   +14 more
core   +1 more source

Urinary CC16 after challenge with dry air hyperpnoea and mannitol in recreational summer athletes [PDF]

, 2013
Airway epithelial injury is regarded as a key contributing factor to the pathogenesis of exercise-induced bronchoconstriction (EIB) in athletes. The concentration of the pneumoprotein club cell (Clara cell) CC16 in urine has been found to be a non ...
Pascale Kippelen, Leena Ali, Ali, Leena, Anderson, Sandra D., Bjermer, Leif, Tufvesson, E, Bjermer, L, Tufvesson, Ellen, Ali, L, Kippelen, P, Kippelen, Pascale, Leif Bjermer, Sandra D. Anderson, Anderson, SD, Ellen Tufvesson, Tufvesson, Ellen,, Bjermer, Leif,, Lund University.   +17 more
core   +1 more source

EGF-induced bronchial epithelial cells drive neutrophil chemotactic and anti-apoptotic activity in asthma [PDF]

, 2013
Chronic damage and repair of the bronchial epithelium are features of asthma. We have previously reported that ex vivo stimulation of normal bronchial epithelial cells with epidermal growth factor (EGF), a key factor of epithelial repair, enhances the ...
Donna E Davies, Cornelius Victoria, Grégory Seumois, Lau, LC, Karl J Staples, Cornelius, Victoria, Dorinsky, P, Victoria Cornelius, Davies Donna E., Dinesh Bagmane (457229), Staples, Karl J., Uddin, Mohib, Ratko Djukanović, Pandurangan Vijayanand, Victoria Cornelius (457230), Lau, Laurie C., Mohib Uddin (457226), Karl J. Staples (457228), Bagmane, Dinesh, Ratko Djukanović (457232), Paul Dorinsky, Pandurangan Vijayanand (277869), Djukanović Ratko, Lau, Laurie C, Grégory Seumois (5656213), Lau Laurie C., Staples, KJ, Vijayanand, P, Vijayanand, Pandurangan, Laurie C. Lau (457227), Seumois, G, Uddin, M, Staples, Karl J, Davies, Donna E, Staples Karl J., Davies, DE, Donna E. Davies (137702), Seumois Grégory, Djukanović, R, Dinesh Bagmane, Djukanović, Ratko, Cornelius, V, Davies, Donna E., Laurie C Lau, Dorinsky Paul, Paul Dorinsky (457231), Dorinsky, Paul, Seumois, Grégory, Bagmane Dinesh, Uddin Mohib, Bagmane, D, Mohib Uddin, Vijayanand Pandurangan   +52 more
core   +2 more sources

Airway Epithelial-Derived Immune Mediators in COVID-19

Viruses, 2023
The airway epithelium, which lines the conducting airways, is central to the defense of the lungs against inhaled particulate matter and pathogens such as SARS-CoV-2, the virus that causes COVID-19.
Tony J. F. Guo, Gurpreet K. Singhera, Janice M. Leung, Delbert R. Dorscheid   +3 more
doaj   +1 more source

Engineering Airway Epithelium [PDF]

, 2018
Airway epithelium is constantly presented with injurious signals, yet under healthy circumstances, the epithelium maintains its innate immune barrier and mucociliary elevator function. This suggests that airway epithelium has regenerative potential (I. R.
Paz, Ana, McGuigan, Alison, Soleas, John P., Marcus, Paula, Waddell, Thomas K.   +4 more
core   +1 more source