Results 11 to 20 of about 62,023 (261)

Airway epithelial cell-specific deletion of HMGB1 exaggerates inflammatory responses in mice with muco-obstructive airway disease

Frontiers in Immunology, 2023
High mobility group box 1 (HMGB1), a ubiquitous chromatin-binding protein required for gene transcription regulation, is released into the extracellular microenvironment by various structural and immune cells, where it is known to act as an alarmin. Here,
Yun Mao, Sonika Patial, Yogesh Saini
doaj   +1 more source

Conserved Mechanisms in the Formation of the Airways and Alveoli of the Lung

Frontiers in Cell and Developmental Biology, 2021
Branching is an intrinsic property of respiratory epithelium that can be induced and modified by signals emerging from the mesenchyme. However, during stereotypic branching morphogenesis of the airway, the relatively thick upper respiratory epithelium ...
David Warburton
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Taste Receptors: The Gatekeepers of the Airway Epithelium [PDF]

Cells, 2021
Taste receptors are well known for their role in the sensation of taste. Surprisingly, the expression and involvement of taste receptors in chemosensory processes outside the tongue have been recently identified in many organs including the airways. Currently, a clear understanding of the airway-specific function of these receptors and the endogenous ...
Martens, Katleen, Steelant, Brecht, Bullens, Dominique M.A.   +2 more
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Apical-Out Human Airway Organoids Modeling SARS-CoV-2 Infection

Viruses, 2023
The respiratory epithelium, particularly the airway epithelium, is the primary infection site for respiratory pathogens. The apical surface of epithelial cells is constantly exposed to external stimuli including invading pathogens. Efforts have been made
Man Chun Chiu, Shuxin Zhang, Cun Li, Xiaojuan Liu, Yifei Yu, Jingjing Huang, Zhixin Wan, Xiaoxin Zhu, Jie Zhou   +8 more
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Establishing Bipotential Human Lung Organoid Culture System and Differentiation to Generate Mature Alveolar and Airway Organoids

Bio-Protocol, 2023
A robust in vitro model of the human respiratory epithelium, including the alveolar and the airway epithelium, is essential for understanding the biology and pathology of the human respiratory system.
Man Chun Chiu, Cun Li, Yifei Yu, Xiaojuan Liu, Jingjing Huang, Zhixin Wan, Kwok Yung Yuen, Jie Zhou   +7 more
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Fibroblast growth factor-9 expression in airway epithelial cells amplifies the type I interferon response and alters influenza A virus pathogenesis.

PLoS Pathogens, 2022
Influenza A virus (IAV) preferentially infects conducting airway and alveolar epithelial cells in the lung. The outcome of these infections is impacted by the host response, including the production of various cytokines, chemokines, and growth factors ...
Bradley E Hiller, Yongjun Yin, Yi-Chieh Perng, Ítalo de Araujo Castro, Lindsey E Fox, Marissa C Locke, Kristen J Monte, Carolina B López, David M Ornitz, Deborah J Lenschow   +9 more
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Pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional

Nature Communications, 2021
Environmental and genetic risk factors affect the distal airway epithelium in idiopatic pulmonary fibrosis (IPF) but the role of the epithelium in IPF remains unclear.
Ian T. Stancil, Jacob E. Michalski, Duncan Davis-Hall, Hong Wei Chu, Jin-Ah Park, Chelsea M. Magin, Ivana V. Yang, Bradford J. Smith, Evgenia Dobrinskikh, David A. Schwartz   +9 more
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Apoptosis and the Airway Epithelium [PDF]

Journal of Allergy, 2011
The airway epithelium functions as a barrier and front line of host defense in the lung. Apoptosis or programmed cell death can be elicited in the epithelium as a response to viral infection, exposure to allergen or to environmental toxins, or to drugs.
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Disparate oxidant gene expression of airway epithelium compared to alveolar macrophages in smokers

Respiratory Research, 2009
Background The small airway epithelium and alveolar macrophages are exposed to oxidants in cigarette smoke leading to epithelial dysfunction and macrophage activation. In this context, we asked: what is the transcriptome of oxidant-related genes in small
Hackett Neil R, Harvey Ben-Gary, Carolan Brendan J, O'Connor Timothy P, Cassano Patricia A, Crystal Ronald G   +5 more
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Airway Epithelial-Derived Immune Mediators in COVID-19

Viruses, 2023
The airway epithelium, which lines the conducting airways, is central to the defense of the lungs against inhaled particulate matter and pathogens such as SARS-CoV-2, the virus that causes COVID-19.
Tony J. F. Guo, Gurpreet K. Singhera, Janice M. Leung, Delbert R. Dorscheid   +3 more
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