IL-25 blockade inhibits metastasis in breast cancer [PDF]
Protein & Cell, 2016 Metastasis is the leading cause of death in breast cancer patients. However, the mechanisms underlying metastasis are not well understood and there is no effective treatment in the clinic.
Zhujun Jiang +5 more
doaj +4 more sources
IL-25 dampens the growth of human germinal center-derived B-cell non Hodgkin Lymphoma by curtailing neoangiogenesis [PDF]
OncoImmunology, 2018 Interleukin (IL)-25, a member of the IL-17 cytokine superfamily, is produced by immune and non-immune cells and exerts type 2 pro-inflammatory effects in vitro and in vivo. The IL-25 receptor(R) is composed of the IL-17RA/IL-17RB subunits.
Elisa Ferretti +9 more
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Interleukin (IL)-25 suppresses IL-22-induced osteoclastogenesis in rheumatoid arthritis via STAT3 and p38 MAPK/IκBα pathway [PDF]
Arthritis Research & Therapy, 2020 Background The present study aimed to evaluate the suppressive role of interleukin (IL)-25 in IL-22-induced osteoclastogenesis and receptor activator of nuclear factor κB ligand (RANKL) expression in rheumatoid arthritis (RA). Methods Serum from patients
Hong Ki Min +7 more
doaj +2 more sources
Roles of IL-25 in Type 2 Inflammation and Autoimmune Pathogenesis [PDF]
Frontiers in Immunology, 2021 Interleukin-17E (IL-25) is a member of the IL-17 cytokine family that includes IL-17A to IL-17F. IL-17 family cytokines play a key role in host defense responses and inflammatory diseases.
Chong Deng +9 more
doaj +2 more sources
The potential role of interleukin (IL)‐25/IL‐33/thymic stromal lymphopoietin (TSLP) on the pathogenesis of idiopathic pulmonary fibrosis [PDF]
The Clinical Respiratory Journal, 2022 Objectives Interleukin (IL)‐25, IL‐33, and thymic stromal lymphopoietin (TSLP) are the important drivers for excessive type‐2 immunity. It has been well elucidated that IL‐25/IL‐33/TSLP plays an important role in allergic airway inflammation and ...
Xuefeng Xu, Huaping Dai, Jinglan Zhang
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Interleukin 25 (IL-25) expression in cholangiocarcinoma. [PDF]
Mol Clin Oncol, 2020 Various cytokines are involved in carcinogenesis and tumor progression. Some tumor cells produce cytokines by themselves. Using secretome analysis, a high expression of APEX-1 was found in cholangiocarcinoma (CCA) cell lines. During this secretome analysis, it was found that CCA cell lines overexpressed some cytokines and related molecules, including ...
Kaewsarabhumi S +7 more
europepmc +4 more sources
Role of IL-25 in Immunity [PDF]
Journal of Clinical and Diagnostic Research, 2015 IL-25 a 2o KDa protein mostly known as IL-17E, encoded by chromosome 14, and containing 117 amino acids. Cytokine IL-17 family consists of 6 members; IL-17A to IL-17F, among which IL-25 has a unique structure and function. The receptor of IL-25 (IL-17BR)
Azar Valizadeh +3 more
doaj +3 more sources
Emerging roles for IL-25 and IL-33 in colorectal cancer tumorigenesis [PDF]
Frontiers in Immunology, 2022 Colorectal cancer (CRC) is the second leading cause of cancer-related death worldwide, and is largely refractory to current immunotherapeutic interventions. The lack of efficacy of existing cancer immunotherapies in CRC reflects the complex nature of the
Eric Jou +2 more
doaj +2 more sources
The Novel Role of MIF in the Secretion of IL-25, IL-31, and IL-33 from PBMC of Patients with Rheumatoid Arthritis [PDF]
Molecules, 2021 Rheumatoid arthritis (RA) is an autoimmune inflammatory joint disease with complex pathogenesis associated with cytokine dysregulation. Macrophage migration inhibitory factor (MIF) plays a role in systemic inflammation and joint destruction in RA and ...
Samuel García-Arellano +5 more
doaj +2 more sources
Assessment of TSLP, IL 25 and IL 33 in patients with shrimp allergy [PDF]
Allergy, Asthma & Clinical Immunology, 2021 Background Shrimp allergy is a growing problem among the European population. TSLP, IL-25 and IL-33 are involved in the pathophysiology of allergic diseases, including asthma and atopic dermatitis, as they activate the Th2-dependent immune response ...
Natalia Ukleja-Sokołowska +4 more
doaj +2 more sources