Roles of IL-25 in Type 2 Inflammation and Autoimmune Pathogenesis [PDF]
Frontiers in Immunology, 2021 Interleukin-17E (IL-25) is a member of the IL-17 cytokine family that includes IL-17A to IL-17F. IL-17 family cytokines play a key role in host defense responses and inflammatory diseases.
Chong Deng +9 more
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Evaluation of the Effects of 1,25VitD3 on Inflammatory Responses and IL-25 Expression [PDF]
Frontiers in Genetics, 2021 VitD3 may contribute to a successful pregnancy through modulation of immune responses, so VitD3 deficiency may have a role in the immunopathogenesis of unexplained recurrent spontaneous abortion (URSA). However, the mechanisms of immunomodulatory actions
Nana Li +10 more
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The potential role of interleukin (IL)‐25/IL‐33/thymic stromal lymphopoietin (TSLP) on the pathogenesis of idiopathic pulmonary fibrosis [PDF]
The Clinical Respiratory Journal, 2022 Objectives Interleukin (IL)‐25, IL‐33, and thymic stromal lymphopoietin (TSLP) are the important drivers for excessive type‐2 immunity. It has been well elucidated that IL‐25/IL‐33/TSLP plays an important role in allergic airway inflammation and ...
Xuefeng Xu, Huaping Dai, Jinglan Zhang
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Emerging roles for IL-25 and IL-33 in colorectal cancer tumorigenesis [PDF]
Frontiers in Immunology, 2022 Colorectal cancer (CRC) is the second leading cause of cancer-related death worldwide, and is largely refractory to current immunotherapeutic interventions. The lack of efficacy of existing cancer immunotherapies in CRC reflects the complex nature of the
Eric Jou +2 more
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The Novel Role of MIF in the Secretion of IL-25, IL-31, and IL-33 from PBMC of Patients with Rheumatoid Arthritis [PDF]
Molecules, 2021 Rheumatoid arthritis (RA) is an autoimmune inflammatory joint disease with complex pathogenesis associated with cytokine dysregulation. Macrophage migration inhibitory factor (MIF) plays a role in systemic inflammation and joint destruction in RA and ...
Samuel García-Arellano +5 more
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Assessment of TSLP, IL 25 and IL 33 in patients with shrimp allergy [PDF]
Allergy, Asthma & Clinical Immunology, 2021 Background Shrimp allergy is a growing problem among the European population. TSLP, IL-25 and IL-33 are involved in the pathophysiology of allergic diseases, including asthma and atopic dermatitis, as they activate the Th2-dependent immune response ...
Natalia Ukleja-Sokołowska +4 more
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Intestinal IL-25 prevents high-fat diet-induced obesity by modulating the cholesterol transporter NPC1L1 expression in the intestinal epithelial cells [PDF]
Scientific ReportsThe intestine is essential for digestion and nutrient absorption, and its altered function contributes to metabolic dysregulation and obesity-induced intestinal inflammation.
Siranart Jeerawattanawart +1 more
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Медицинская иммунология, 2021 Atopic dermatitis is one of the most common chronic inflammatory skin diseases caused by both terminal defects in keratinocyte differentiation, and pronounced type 2 immune responses.
M. B. Drozhdina, E. V. Suslova
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Interleukin 25 and its biological features and function in intestinal diseases
Central European Journal of Immunology, 2023 Interleukin 25 (IL-25), also known as IL-17E, is a member of the IL-17 cytokine family and an important regulator of the type 2 immune response. Accumulating evidence suggests that IL-25 interacts with diverse immune as well as non-immune cells and plays
Wei Jiang +3 more
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Epithelial cell alarmin cytokines: Frontline mediators of the asthma inflammatory response
Frontiers in Immunology, 2022 The exposure of the airway epithelium to external stimuli such as allergens, microbes, and air pollution triggers the release of the alarmin cytokines IL-25, IL-33 and thymic stromal lymphopoietin (TSLP). IL-25, IL-33 and TSLP interact with their ligands,
Marc Duchesne, Isobel Okoye, Paige Lacy
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