Results 1 to 10 of about 16,704 (236)

Targeting TSLP in Asthma

Journal of Asthma and Allergy, 2022
Jane R Parnes,1 Nestor A Molfino,1 Gene Colice,2 Ubaldo Martin,2 Jonathan Corren,3 Andrew Menzies-Gow4 1Amgen, Thousand Oaks, CA, USA; 2AstraZeneca, Gaithersburg, MD, USA; 3University of California, Los Angeles, CA, USA; 4Royal Brompton and Harefield ...
Jonathan Corren, Andrew Menzies-Gow, Ubaldo José Martin   +2 more
exaly   +6 more sources

Mouse Models of Allergic Diseases: TSLP and Its Functional Roles [PDF]

Allergology International, 2012
The cytokine TSLP was originally identified in a murine thymic stromal cell line as a lymphoid growth factor. After the discovery of TSLP, extensive molecular genetic analyses and gene targeting experiments have demonstrated that TSLP plays an essential ...
Hongwei Han
exaly   +4 more sources

Cellular and Molecular Mechanisms of TSLP Function in Human Allergic Disorders - TSLP Programs the “Th2 code” in Dendritic Cells [PDF]

Allergology International, 2012
Thymic stromal lymphopoietin (TSLP) has been recently implicated as a key molecule for initiating allergic inflammation at the epithelial cell-dendritic cell (DC) interface.
Tomoki Itô, Kazuhiko Arima
exaly   +4 more sources

TSLP: contrasting roles in cancer

Frontiers in Immunology
Thymic stromal lymphopoietin (TSLP) is an alarmin cytokine possessing a plethora of pleiotropic properties. Human and mouse TSLP exerts their activity via a heterodimeric complex composed of TSLP receptor (TSLPR) chain and IL-7Rα.
Remo Poto, Hongwei Han, Gilda Varricchi   +2 more
exaly   +6 more sources

Anti-TSLP antibodies: Targeting a master regulator of type 2 immune responses

Allergology International, 2020
TSLP is an epithelial cell-derived cytokine synthesized in response to various stimuli, including protease allergens and microorganisms like viruses and bacteria. Biological functions of TSLP require heterodimer formation between the TSLP receptor (TSLPR)
Hiroki Kabata, Kenji Kabashima, Koichiro Asano   +2 more
exaly   +3 more sources

Thymic stromal lymphopoietin promotes abdominal aortic aneurysm formation by regulating macrophage polarization [PDF]

Frontiers in Immunology
BackgroundThe inflammatory cytokine thymic stromal lymphopoietin (TSLP) has pleiotropic roles in immune response and tissue homeostasis, yet its function in abdominal aortic aneurysm (AAA) remains entirely unexplored.MethodsWe integrated clinical ...
Qi Zheng, Qi Zheng, Qi Zheng, Xuhong Wang, Xuhong Wang, Xuhong Wang, Xinglin Chen, Xinglin Chen, Xinglin Chen, Mingkai Huang, Mingkai Huang, Mingkai Huang, Xuzhe Zhang, Xuzhe Zhang, Xuzhe Zhang, Qinlin Li, Qinlin Li, Qinlin Li, Zhengjie Huang, Zhengjie Huang, Zhengjie Huang, Mingyi Li, Mingyi Li, Mingyi Li, Jingyong Li, Jingyong Li, Jingyong Li, Wangling Hu, Wangling Hu, Wangling Hu, Ni Xia, Ni Xia, Ni Xia, Lingfeng Zha, Lingfeng Zha, Lingfeng Zha, Jiao Jiao, Jiao Jiao, Jiao Jiao, Fen Yang, Fen Yang, Fen Yang, Tingting Tang, Tingting Tang, Tingting Tang, Xiang Cheng, Xiang Cheng, Xiang Cheng   +47 more
doaj   +2 more sources

TSLP and asthma: fellow travelers [PDF]

Exploration of Asthma & Allergy, 2023
The incidence of asthma, a heterogeneous inflammatory disease affecting over 300 million people worldwide, continues to increase in developed countries.
David El-Qutob, Antonio Letran
doaj   +1 more source

TSLP promoting B cell proliferation and polarizing follicular helper T cell as a therapeutic target in IgG4-related disease

Journal of Translational Medicine, 2022
Objective To figure out the functions of thymic stromal lymphopoietin (TSLP) in IgG4-related disease (IgG4-RD). Methods Plasma TSLP levels were tested by Elisa, and its receptors were detected by flow cytometry.
Hui Lu, Xunyao Wu, Yu Peng, Ruijie Sun, Yuxue Nie, Jingna Li, Mu Wang, Yaping Luo, Linyi Peng, Yunyun Fei, Jiaxin Zhou, Wen Zhang, Xiaofeng Zeng   +12 more
doaj   +1 more source

SARS-CoV-2-Induced TSLP Is Associated with Duration of Hospital Stay in COVID-19 Patients

Viruses, 2023
Thymic stromal lymphopoietin (TSLP) is an epithelium-derived pro-inflammatory cytokine involved in lung inflammatory responses. Previous studies show conflicting observations in blood TSLP in COVID-19, while none report SARS-CoV-2 inducing TSLP ...
Luke Gerla, Subhabrata Moitra, Desmond Pink, Natasha Govindasamy, Marc Duchesne, Eileen Reklow, Angela Hillaby, Amy May, John D. Lewis, Lyle Melenka, Tom C. Hobman, Irvin Mayers, Paige Lacy   +12 more
doaj   +1 more source

Interactions of thymic stromal lymphopoietin with interleukin-4 in adaptive immunity during Aspergillus fumigatus keratitis [PDF]

International Journal of Ophthalmology, 2021
AIM: To investigate the potential interactions of thymic stromal lymphopoietin (TSLP) with interleukin-4 (IL-4) in adaptive immunity during fungal keratitis (FK).
Chen Chen, Chen-Yang Dai, Fang Han, Jia-Yin Wu, Lin Sun, Xin-Yi Wu   +5 more
doaj   +1 more source