Thymic Stromal Lymphopoietin (TSLP), Its Isoforms and the Interplay With the Epithelium in Allergy and Asthma [PDF]
International Journal of Molecular Sciences, 2023 Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine that has emerged as a critical player in the development and progression of allergy and asthma. It is primarily produced by epithelial cells and functions as a potent immune system activator.
Darío Antolín-Amérigo +2 more
exaly +6 more sources
The potential role of interleukin (IL)‐25/IL‐33/thymic stromal lymphopoietin (TSLP) on the pathogenesis of idiopathic pulmonary fibrosis [PDF]
The Clinical Respiratory Journal, 2022 Objectives Interleukin (IL)‐25, IL‐33, and thymic stromal lymphopoietin (TSLP) are the important drivers for excessive type‐2 immunity. It has been well elucidated that IL‐25/IL‐33/TSLP plays an important role in allergic airway inflammation and ...
Xuefeng Xu, Huaping Dai, Jinglan Zhang
doaj +2 more sources
Fine Particulate matter (PM2.5) is a risk factor for dermatitis by promoting the expression of thymic stromal lymphopoietin (TSLP) in keratinocytes [PDF]
Indian Journal of Dermatology, 2020 Aim: Common indoor pollutants, as fine particulate matter (PM2.5), can damage people's health and cause skin allergies. However, it remains unknown which common pollutants can lead to allergy, such as, in children atopic dermatitis, and what is the key ...
Fei Li +4 more
doaj +2 more sources
Alarmins differentially modulate airway contraction and relaxation of human small airways [PDF]
Respiratory ResearchAlarmins, including Thymic Stromal Lymphopoietin (TSLP) and Interleukins 33 and 25 (IL-33 and IL-25), contribute to the pathophysiology of allergic and nonallergic asthma by evoking exacerbations in response to allergens, viruses, and environmental ...
Joshua L. Kennedy +3 more
doaj +2 more sources
TSLP and asthma: fellow travelers [PDF]
Exploration of Asthma & Allergy, 2023 The incidence of asthma, a heterogeneous inflammatory disease affecting over 300 million people worldwide, continues to increase in developed countries.
David El-Qutob, Antonio Letran
doaj +1 more source
Effects of Resveratrol on Thymic Stromal Lymphopoietin Expression in Mast Cells
Medicina, 2020 Background and objectives: Cytokine thymic stromal lymphopoietin (TSLP) plays a pivotal role in the pathogenesis of atopic diseases such as atopic dermatitis, allergic rhinitis, and asthma. Resveratrol (RSV) exerts various pharmacological effects such as
Phil-Dong Moon +6 more
doaj +1 more source
The Role of TSLP in Atopic Dermatitis: From Pathogenetic Molecule to Therapeutical Target
Mediators of Inflammation, 2023 Atopic dermatitis (AD) is a kind of chronic skin disease with inflammatory infiltration, characterized by skin barrier dysfunction, immune response dysregulation, and skin dysbiosis.
Jialiang Luo +9 more
doaj +1 more source
Role of the TSLP and its Receptor in the Treatment of Asthma
Barcelona Respiratory Network Reviews, 2023 Thymic stromal lymphopoietin (TSLP) is a crucial cytokine in initiating and regulating immune responses. Various cell types, including epithelial cells, fibroblasts, and dendritic cells, synthesize TSLP. TSLP activates dendritic cells, which subsequently
Miguel Estravís +2 more
doaj +1 more source
Thymic Stromal Lymphopoietin and Cancer: Th2-Dependent and -Independent Mechanisms
Frontiers in Immunology, 2020 The thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine originally cloned from a murine thymic stromal cell line, and subsequently a human homolog was identified using database search methods.
Maria Pia Protti +3 more
doaj +1 more source
TSLP activates the production of IFN-γ via CD8-positive T cells in recurrent tonsillitis
Clinical Immunology Communications, 2022 The role of thymic stromal lymphopoietin (TSLP) in chronic infection is not well understood. We report an increased number of cluster of differentiation 8 (CD8+ T) cells and higher expression of TSLP in the tonsil tissues of patients with recurrent ...
Kota Hiraoka +5 more
doaj +1 more source