Results 21 to 30 of about 152,280 (211)

Andrographolide suppresses thymic stromal lymphopoietin in phorbol myristate acetate/calcium ionophore A23187-activated mast cells and 2,4-dinitrofluorobenzene-induced atopic dermatitis-like mice model

Drug Design, Development and Therapy, 2016
Chun-xiao Li,* Hua-guo Li,* Hui Zhang,* Ru-hong Cheng, Ming Li, Jian-ying Liang, Yan Gu, Bo Ling, Zhi-rong Yao, Hong Yu Department of Dermatology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of ...
Li CX, Li HG, Zhang H, Cheng RH, Li M, Liang JY, Gu Y, Ling B, Yao ZR, Yu H   +9 more
doaj   +1 more source

Regulation of Thymic Stromal Lymphopoietin (TSLP) receptor expression [PDF]

Allergy, Asthma & Clinical Immunology, 2010
Objective/purpose TSLP plays a major role in the induction and effector phases of allergic diseases by acting on dendritic cells, mast cells (MCs), T cells and CD34 hemopoietic progenitor cells. Whereas the cellular origin and the mechanisms regulating TSLP production are well documented, little is known about the regulation of TSLP receptor expression.
Allakhverdi Zoulfia, Delespesse Guy
doaj   +3 more sources

Achieving clinical and histologic remission with tezepelumab in an adolescent with refractory eosinophilic gastrointestinal disease: A case report [PDF]

JPGN Rep
Abstract Tezepelumab is a human monoclonal antibody that binds to human thymic stromal lymphopoietin (TSLP), an epithelial cytokine that plays a role in Type 2 signaling. We describe a 17‐year‐old with a history of eosinophilic esophagitis (EoE) and eosinophilic gastroenteritis who demonstrated response to tezepelumab with both clinical and histologic ...
Newsome D, Sharlin C, Bauer C, Schroeder S.   +3 more
europepmc   +2 more sources

The Biology of Thymic Stromal Lymphopoietin (TSLP) [PDF]

, 2013
Originally shown to promote the growth and activation of B cells, thymic stromal lymphopoietin (TSLP) is now known to have wide-ranging impacts on both hematopoietic and nonhematopoietic cell lineages, including dendritic cells, basophils, eosinophils, mast cells, CD4⁺, CD8⁺ and natural killer T cells, B cells and epithelial cells. While TSLP's role in
Steven F, Ziegler, Florence, Roan, Bryan D, Bell, Thomas A, Stoklasek, Masayuki, Kitajima, Hongwei, Han   +5 more
openaire   +2 more sources

Distinct Roles for Thymic Stromal Lymphopoietin (TSLP) and IL-33 in Experimental Eosinophilic Esophagitis. [PDF]

Allergy
Abstract Rationale Thymic stromal lymphopoietin (TSLP) and IL-33 are alarmins implicated in EoE pathogenesis by activating multiple cells including mast cells (MCs). Whether TSLP or IL-33 have a role in EoE and whether their activities are distinct requires further investigation.
Dsilva A, Wagner A, Itan M, Rhone N, Avlas S, Gordon Y, Davidian N, Sharma S, Razravina E, Zan-Bar I, Parnes JR, Gorski KS, Sherrill JD, Varol C, Ziegler SF, Rothenberg ME, Munitz A.   +16 more
europepmc   +4 more sources

Characterization of the function of thymic stromal lymphopoietin in lymphopoiesis and lymph node organogenesis [PDF]

, 2010
Interleukin (IL)-7 is a cytokine, which is crucial for the development of the murine immune system. It is required for lymphopoiesis and for the development of peripheral lymph nodes (LN). IL-7-/-mice have impaired B and T cell lymphopoiesis, decreased
Chappaz, Stéphane
core   +1 more source

Exacerbation of Allergic Diseases by Chemicals: Role of TSLP

Journal of Pharmacological Sciences, 2014
Environmental chemicals, such as cigarette smoke and diesel exhaust, have been reported as risk factors that exacerbate allergic diseases. However, the exacerbation mechanisms induced by these chemicals are not yet fully understood.
Ryosuke Segawa, Noriyasu Hirasawa
doaj   +1 more source

Thymic Stromal Lymphopoietin Induction Suppresses Lung Cancer Development

, 2022
SIMPLE SUMMARY: The recurrence rate for lung cancer is high after the removal of the primary tumor. Herein, we demonstrate the potential of immunotherapy against lung cancer by examining the impact of Thymic Stromal Lymphopoietin (TSLP) cytokine ...
Azin, Marjan, Michael P. Stover, Matthew T. McGoldrick, Marjan Azin, Guennoun, Ranya, Kathryn E. Trerice, Shadmehr Demehri, Stover, Michael P., Jennet Hojanazarova, Ranya Guennoun, Erik B. Schiferle, Trerice, Kathryn E., Schiferle, Erik B., Demehri, Shadmehr, Hojanazarova, Jennet, McGoldrick, Matthew T.   +15 more
core   +1 more source

Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma

Nature Communications, 2017
The pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP) is a promising therapeutic target. Here the authors characterize the assembly mechanism of the receptor complex driven by human TSLP, and its antagonism by the monoclonal antibody ...
Kenneth Verstraete, Frank Peelman, Harald Braun, Juan Lopez, Dries Van Rompaey, Ann Dansercoer, Isabel Vandenberghe, Kris Pauwels, Jan Tavernier, Bart N. Lambrecht, Hamida Hammad, Hans De Winter, Rudi Beyaert, Guy Lippens, Savvas N. Savvides   +14 more
doaj   +1 more source

Food allergy in mice is modulated through the thymic stromal lymphopoietin pathway [PDF]

, 2015
Thymic stromal lymphopoietin (TSLP) is involved in the pathogenesis of allergic reactions in the skin and the lung. Nevertheless, data on the role of TSLP in food allergy are scarce.
Simone C. Zimmerli, Rincon Garriz, José Maria, Christophe P. Frossard, Frossard, Christophe, Philippe A. Eigenmann, José M. Rincon Garriz, Eigenmann, Philippe, Zimmerli, Simone   +7 more
core   +1 more source