Results 21 to 30 of about 8,456 (180)
Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma
Nature Communications, 2017 The pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP) is a promising therapeutic target. Here the authors characterize the assembly mechanism of the receptor complex driven by human TSLP, and its antagonism by the monoclonal antibody ...
Kenneth Verstraete +14 more
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The role of thymic stromal lymphopoietin (TSLP) in allergic disorders [PDF]
Current Opinion in Immunology, 2010 The importance of the epithelium in initiating and controlling immune responses is becoming more appreciated. For example, allergen contact first occurs at mucosal sites exposed to the external environment, such as the skin, airways and gastrointestinal tract.
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Haematologica, 2016 Thymic stromal lymphopoietin (TSLP) stimulates in vitro proliferation of human fetal B-cell precursors. However, its in vivo role during normal human B lymphopoiesis is unknown.
Olivia L. Francis +22 more
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Thymic stromal lymphopoietin limits primary and recall CD8+ T-cell anti-viral responses
eLife, 2021 Thymic stromal lymphopoietin (TSLP) is a cytokine that acts directly on CD4+ T cells and dendritic cells to promote progression of asthma, atopic dermatitis, and allergic inflammation.
Risa Ebina-Shibuya +10 more
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TSLP is involved in expansion of early thymocyte progenitors
BMC Immunology, 2007 Background Thymic stromal derived lymphopoietin (TSLP) is preferentially and highly expressed in the thymus, but its function in T cell development is not clear.
Coffield V McNeil +3 more
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Peripheral blood TSLP (thymic stromal lymphopoietin) in children as a biomarker?
Paediatric asthma and allergy, 2021 Introduction There is substantial evidence that alarmin TSLP plays one of the key roles in driving type 2 inflammation and it is also thought that it has a role in neutrophilic, type 2-low airway inflammation. There is much less known about the role of alarmins in type 2-low asthma and its role in the heterogeneity of inflammation in acute asthma ...
Vrsalovic, Renata +6 more
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Thymic Stromal Lymphopoietin in Cutaneous Immune-Mediated Diseases
Frontiers in Immunology, 2021 Thymic stromal lymphopoietin (TSLP) was initially demonstrated to be critical in regulating inflammatory responses among various allergic disorders (such as atopic dermatitis, food allergy, and asthma). Although two isoforms (short form and long form) of
Si-Hang Wang, Ya-Gang Zuo
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Clinical, Cosmetic and Investigational Dermatology, 2022 Yu-qing Hu, Jian-zhong Zhang Department of Dermatology, Peking University People’s Hospital, Beijing, People’s Republic ChinaCorrespondence: Jian-zhong Zhang, Tel +86-10-88325472, Fax +86-10-68318386, Email rmzjz@126.comBackground: Bullous pemphigoid (BP)
Hu YQ, Zhang JZ
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Medicina, 2020 Background: Viral infection is the main cause of asthma and COPD (chronic obstructive pulmonary disease) exacerbation and accumulate inflammatory cells to airway tissue.
Tetsuya Homma +23 more
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Thymic stromal lymphopoietin-stimulated CD4+ T cells induce senescence in advanced breast cancer
Frontiers in Cell and Developmental Biology, 2022 Thymic Stromal Lymphopoietin (TSLP) plays a prominent role in inducing type 2 immune response, commonly associated with atopic diseases. TSLP-activated CD4+ T helper 2 cells block early carcinogenesis by inducing terminal differentiation in spontaneous ...
Margherita Boieri +13 more
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