Results 11 to 20 of about 8,456 (180)

The Role of Thymic Stromal Lymphopoietin (TSLP) in Glomerulonephritis [PDF]

Childhood Kidney Diseases, 2018
Thymic stromal lymphopoietin (TSLP) is an interleukin-7-like cytokine that is an important trigger and initiator of many allergic diseases. TSLP promotes a T-helper type 2 (Th2) cytokine response that can be pathological. A relationship is formed both at
Keum Hwa Lee, Jae Won Yang, Jin Young Cho, Joo Yup Lee, Eun Kyung Lim, Michael Eisenhut, Dong Yeon Jeong, Johanna Steingroever, Jae Il Shin   +8 more
doaj   +4 more sources

Signal transduction around thymic stromal lymphopoietin (TSLP) in atopic asthma [PDF]

Cell Communication and Signaling, 2008
Thymic stromal lymphopoietin (TSLP), a novel interleukin-7-like cytokine, triggers dendritic cell-mediated inflammatory responses ultimately executed by T helper cells of the Th2 subtype.
Kuepper Michael, Borowski Andreas, Sebastian Katrin, Friedrich Karlheinz   +3 more
doaj   +3 more sources

Regulation of Thymic Stromal Lymphopoietin (TSLP) receptor expression [PDF]

Allergy, Asthma & Clinical Immunology, 2010
Objective/purpose TSLP plays a major role in the induction and effector phases of allergic diseases by acting on dendritic cells, mast cells (MCs), T cells and CD34 hemopoietic progenitor cells. Whereas the cellular origin and the mechanisms regulating TSLP production are well documented, little is known about the regulation of TSLP receptor expression.
Allakhverdi Zoulfia, Delespesse Guy
doaj   +3 more sources

The biology of thymic stromal lymphopoietin (TSLP). [PDF]

Adv Pharmacol, 2013
Originally shown to promote the growth and activation of B cells, thymic stromal lymphopoietin (TSLP) is now known to have wide-ranging impacts on both hematopoietic and nonhematopoietic cell lineages, including dendritic cells, basophils, eosinophils, mast cells, CD4⁺, CD8⁺ and natural killer T cells, B cells and epithelial cells. While TSLP's role in
Ziegler SF, Roan F, Bell BD, Stoklasek TA, Kitajima M, Han H.   +5 more
europepmc   +4 more sources

Thymic stromal lymphopoietin (TSLP) is associated with allergic rhinitis in children with asthma [PDF]

Clinical and Molecular Allergy, 2011
Allergic rhinitis (AR) affects up to 80% of children with asthma and increases asthma severity. Thymic stromal lymphopoietin (TSLP) is a key mediator of allergic inflammation. The role of the TSLP gene (TSLP) in the pathogenesis of AR has not been studied.To test for associations between variants in TSLP, TSLP-related genes, and AR in children with ...
Bunyavanich, S, Melen, E, Wilk, JB, Granada, M, Soto-Quiros, ME, Avila, L, Lasky-Su, J, Hunninghake, GM, Wickman, M, Pershagen, G, O'Connor, GT, Weiss, ST, Celedn, JC   +12 more
openaire   +6 more sources

Thymic Stromal Lymphopoietin (TSLP) Is Cleaved by Human Mast Cell Tryptase and Chymase. [PDF]

Int J Mol Sci
Thymic stromal lymphopoietin (TSLP), mainly expressed by epithelial cells, plays a central role in asthma. In humans, TSLP exists in two variants: the long form TSLP (lfTSLP) and a shorter TSLP isoform (sfTSLP). Macrophages (HLMs) and mast cells (HLMCs) are in close proximity in the human lung and play key roles in asthma.
Canè L, Poto R, Palestra F, Iacobucci I, Pirozzi M, Parashuraman S, Ferrara AL, Illiano A, La Rocca A, Mercadante E, Pucci P, Marone G, Spadaro G, Loffredo S, Monti M, Varricchi G.   +15 more
europepmc   +5 more sources

Distinct Roles for Thymic Stromal Lymphopoietin (TSLP) and IL-33 in Experimental Eosinophilic Esophagitis. [PDF]

Allergy
Abstract Rationale Thymic stromal lymphopoietin (TSLP) and IL-33 are alarmins implicated in EoE pathogenesis by activating multiple cells including mast cells (MCs). Whether TSLP or IL-33 have a role in EoE and whether their activities are distinct requires further investigation.
Dsilva A, Wagner A, Itan M, Rhone N, Avlas S, Gordon Y, Davidian N, Sharma S, Razravina E, Zan-Bar I, Parnes JR, Gorski KS, Sherrill JD, Varol C, Ziegler SF, Rothenberg ME, Munitz A.   +16 more
europepmc   +4 more sources

Cloning of the Murine Thymic Stromal Lymphopoietin (Tslp) Receptor [PDF]

The Journal of Experimental Medicine, 2000
The cellular receptor for murine thymic stromal lymphopoietin (TSLP) was detected in a variety of murine, but not human myelomonocytic cell lines by radioligand binding. cDNA clones encoding the receptor were isolated from a murine T helper cell cDNA library. TSLP receptor (TSLPR) is a member of the hematopoietin receptor family.
Linda S. Park, Unja Martin, Kirsten Garka, Brian Gliniak, James P. Di Santo, Werner Muller, David A. Largaespada, Neal G. Copeland, Nancy A. Jenkins, Andrew G. Farr, Steven F. Ziegler, Philip J. Morrissey, Raymond Paxton, John E. Sims   +13 more
openaire   +1 more source

Exacerbation of Allergic Diseases by Chemicals: Role of TSLP

Journal of Pharmacological Sciences, 2014
Environmental chemicals, such as cigarette smoke and diesel exhaust, have been reported as risk factors that exacerbate allergic diseases. However, the exacerbation mechanisms induced by these chemicals are not yet fully understood.
Ryosuke Segawa, Noriyasu Hirasawa
doaj   +1 more source

Thymic Stromal Lymphopoietin Isoforms, Inflammatory Disorders, and Cancer

Frontiers in Immunology, 2018
Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine originally isolated from a murine thymic stromal cell line. TSLP exerts its biological effects by binding to a high-affinity heteromeric complex composed of thymic stromal lymphopoietin ...
Gilda Varricchi, Gilda Varricchi, Antonio Pecoraro, Antonio Pecoraro, Giancarlo Marone, Giancarlo Marone, Gjada Criscuolo, Gjada Criscuolo, Giuseppe Spadaro, Giuseppe Spadaro, Arturo Genovese, Arturo Genovese, Gianni Marone, Gianni Marone, Gianni Marone   +14 more
doaj   +1 more source