Thymic Stromal Lymphopoietin (TSLP) Is Cleaved by Human Mast Cell Tryptase and Chymase [PDF]
International Journal of Molecular SciencesThymic stromal lymphopoietin (TSLP), mainly expressed by epithelial cells, plays a central role in asthma. In humans, TSLP exists in two variants: the long form TSLP (lfTSLP) and a shorter TSLP isoform (sfTSLP). Macrophages (HLMs) and mast cells (HLMCs) are in close proximity in the human lung and play key roles in asthma.
Luisa Canè +15 more
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The potential role of interleukin (IL)‐25/IL‐33/thymic stromal lymphopoietin (TSLP) on the pathogenesis of idiopathic pulmonary fibrosis [PDF]
The Clinical Respiratory Journal, 2022 Objectives Interleukin (IL)‐25, IL‐33, and thymic stromal lymphopoietin (TSLP) are the important drivers for excessive type‐2 immunity. It has been well elucidated that IL‐25/IL‐33/TSLP plays an important role in allergic airway inflammation and ...
Xuefeng Xu, Huaping Dai, Jinglan Zhang
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Thymic Stromal Lymphopoietin: To Cut a Long Story ShortSummary [PDF]
Cellular and Molecular Gastroenterology and Hepatology, 2017 Thymic stromal lymphopoietin (TSLP) was identified more than 20 years ago as a secreted factor of a mouse thymic stromal cell line; later, a human orthologue was also identified.
Katerina Tsilingiri +2 more
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Thymic Stromal Lymphopoietin Isoforms, Inflammatory Disorders, and Cancer [PDF]
Frontiers in Immunology, 2018 Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine originally isolated from a murine thymic stromal cell line. TSLP exerts its biological effects by binding to a high-affinity heteromeric complex composed of thymic stromal lymphopoietin ...
Gilda Varricchi +14 more
doaj +2 more sources
Thymic stromal lymphopoietin (TSLP) is associated with allergic rhinitis in children with asthma [PDF]
Clinical and Molecular Allergy, 2011 Allergic rhinitis (AR) affects up to 80% of children with asthma and increases asthma severity. Thymic stromal lymphopoietin (TSLP) is a key mediator of allergic inflammation. The role of the TSLP gene (TSLP) in the pathogenesis of AR has not been studied.To test for associations between variants in TSLP, TSLP-related genes, and AR in children with ...
Bunyavanich, S +12 more
core +8 more sources
Role of thymic stromal lymphopoietin (TSLP) in asthma [PDF]
, 2021 Thymic Stromal Lymphopoietin (TSLP) is a pleiotropic cytokine originally isolated from a murine thymic stromal cell line and characterized as a lymphocyte growth factor. TSLP is predominantly expressed by lung and gut epithelial cells, keratinocytes, and by dendritic cells (DCs). TSLP can be produced also by airway smooth muscle (ASM) cells, mast cells,
Criscuolo, Gjada
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Fine Particulate matter (PM2.5) is a risk factor for dermatitis by promoting the expression of thymic stromal lymphopoietin (TSLP) in keratinocytes [PDF]
Indian Journal of Dermatology, 2020 Aim: Common indoor pollutants, as fine particulate matter (PM2.5), can damage people's health and cause skin allergies. However, it remains unknown which common pollutants can lead to allergy, such as, in children atopic dermatitis, and what is the key ...
Fei Li +4 more
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Dynamic Thymic Stromal Lymphopoietin and Its Receptor Complex Expression on Skin Langerhans Cells in Response to MC903-induced Skin Inflammation [PDF]
Eur J ImmunolThymic Stromal Lymphopoietin (TSLP) regulates the skin microenvironment during type 2 inflammation. Epidermal APCs, Langerhans cells (LCs), might be the target of TSLP, but whether LCs express CD127 needed for TSLP signaling has been unclear.
Salomaa, Tanja +7 more
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Natural Compounds Targeting Thymic Stromal Lymphopoietin (TSLP): A Promising Therapeutic Strategy for Atopic Dermatitis [PDF]
BiomoleculesAtopic dermatitis (AD) is a chronic inflammatory skin disease with rising prevalence, marked by eczematous lesions, itching, and a weakened skin barrier often tied to filaggrin gene mutations. This breakdown allows allergen and microbe entry, with thymic
Chiara Moltrasio +9 more
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Drug Design, Development and Therapy, 2016 Chun-xiao Li,* Hua-guo Li,* Hui Zhang,* Ru-hong Cheng, Ming Li, Jian-ying Liang, Yan Gu, Bo Ling, Zhi-rong Yao, Hong Yu Department of Dermatology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of ...
Li CX +9 more
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