Results 11 to 20 of about 152,280 (211)

The Role of Thymic Stromal Lymphopoietin (TSLP) in Glomerulonephritis [PDF]

Childhood Kidney Diseases, 2018
Thymic stromal lymphopoietin (TSLP) is an interleukin-7-like cytokine that is an important trigger and initiator of many allergic diseases. TSLP promotes a T-helper type 2 (Th2) cytokine response that can be pathological. A relationship is formed both at
Keum Hwa Lee, Jae Won Yang, Jin Young Cho, Joo Yup Lee, Eun Kyung Lim, Michael Eisenhut, Dong Yeon Jeong, Johanna Steingroever, Jae Il Shin   +8 more
doaj   +8 more sources

Signal transduction around thymic stromal lymphopoietin (TSLP) in atopic asthma [PDF]

Cell Communication and Signaling, 2008
Thymic stromal lymphopoietin (TSLP), a novel interleukin-7-like cytokine, triggers dendritic cell-mediated inflammatory responses ultimately executed by T helper cells of the Th2 subtype.
Kuepper Michael, Borowski Andreas, Sebastian Katrin, Friedrich Karlheinz   +3 more
doaj   +5 more sources

Thymic Stromal Lymphopoietin: To Cut a Long Story ShortSummary [PDF]

Cellular and Molecular Gastroenterology and Hepatology, 2017
Thymic stromal lymphopoietin (TSLP) was identified more than 20 years ago as a secreted factor of a mouse thymic stromal cell line; later, a human orthologue was also identified.
Katerina Tsilingiri, Giulia Fornasa, Maria Rescigno   +2 more
doaj   +2 more sources

Cloning of the Murine Thymic Stromal Lymphopoietin (Tslp) Receptor [PDF]

The Journal of Experimental Medicine, 2000
The cellular receptor for murine thymic stromal lymphopoietin (TSLP) was detected in a variety of murine, but not human myelomonocytic cell lines by radioligand binding. cDNA clones encoding the receptor were isolated from a murine T helper cell cDNA library. TSLP receptor (TSLPR) is a member of the hematopoietin receptor family.
Park, Linda S., Martin, Unja, Garka, Kirsten, Gliniak, Brian, Di Santo, James P., Muller, Werner; id_orcid 0000-0002-1297-9725, Largaespada, David A., Copeland, Neal G., Jenkins, Nancy A., Farr, Andrew G., Ziegler, Steven F., Morrissey, Philip J., Paxton, Raymond, Sims, John E.   +13 more
openaire   +3 more sources

Role of thymic stromal lymphopoietin (TSLP) in asthma [PDF]

, 2021
Thymic Stromal Lymphopoietin (TSLP) is a pleiotropic cytokine originally isolated from a murine thymic stromal cell line and characterized as a lymphocyte growth factor. TSLP is predominantly expressed by lung and gut epithelial cells, keratinocytes, and by dendritic cells (DCs). TSLP can be produced also by airway smooth muscle (ASM) cells, mast cells,
Criscuolo, Gjada
core   +3 more sources

Thymic stromal lymphopoietin (TSLP) is a substrate for tryptase in patients with mastocytosis

European Journal of Internal Medicine, 2023
Mastocytosis is a heterogeneous disease associated to uncontrolled proliferation and increased density of mast cells in different organs. This clonal disorder is related to gain-of-function pathogenic variants of the c-kit gene that encodes for KIT (CD117) expressed on mast cell membrane.
Simone Marcella, Angelica Petraroli, Luisa Canè, Anne Lise Ferrara, Remo Poto, Roberta Parente, Francesco Palestra, Leonardo Cristinziano, Luca Modestino, Maria Rosaria Galdiero, Maria Monti, Gianni Marone, Massimo Triggiani, Gilda Varricchi, Stefania Loffredo   +14 more
core   +5 more sources

Thymic Stromal Lymphopoietin Isoforms, Inflammatory Disorders, and Cancer [PDF]

Frontiers in Immunology, 2018
Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine originally isolated from a murine thymic stromal cell line. TSLP exerts its biological effects by binding to a high-affinity heteromeric complex composed of thymic stromal lymphopoietin ...
Gilda Varricchi, Gilda Varricchi, Antonio Pecoraro, Antonio Pecoraro, Giancarlo Marone, Giancarlo Marone, Gjada Criscuolo, Gjada Criscuolo, Giuseppe Spadaro, Giuseppe Spadaro, Arturo Genovese, Arturo Genovese, Gianni Marone, Gianni Marone, Gianni Marone   +14 more
doaj   +2 more sources

Thymic stromal lymphopoietin (TSLP) is associated with allergic rhinitis in children with asthma [PDF]

Clinical and Molecular Allergy, 2011
Allergic rhinitis (AR) affects up to 80% of children with asthma and increases asthma severity. Thymic stromal lymphopoietin (TSLP) is a key mediator of allergic inflammation. The role of the TSLP gene (TSLP) in the pathogenesis of AR has not been studied.To test for associations between variants in TSLP, TSLP-related genes, and AR in children with ...
Bunyavanich, S, Melen, E, Wilk, JB, Granada, M, Soto-Quiros, ME, Avila, L, Lasky-Su, J, Hunninghake, GM, Wickman, M, Pershagen, G, O'Connor, GT, Weiss, ST, Celedn, JC   +12 more
core   +8 more sources

Thymic Stromal Lymphopoietin (TSLP) Is Cleaved by Human Mast Cell Tryptase and Chymase. [PDF]

Int J Mol Sci
Thymic stromal lymphopoietin (TSLP), mainly expressed by epithelial cells, plays a central role in asthma. In humans, TSLP exists in two variants: the long form TSLP (lfTSLP) and a shorter TSLP isoform (sfTSLP). Macrophages (HLMs) and mast cells (HLMCs) are in close proximity in the human lung and play key roles in asthma.
Canè L, Poto R, Palestra F, Iacobucci I, Pirozzi M, Parashuraman S, Ferrara AL, Illiano A, La Rocca A, Mercadante E, Pucci P, Marone G, Spadaro G, Loffredo S, Monti M, Varricchi G.   +15 more
europepmc   +7 more sources

Tezepelumab. Anti-TSLP (thymic stromal lymphopoietin), Treatment of severe asthma

Drugs of the Future, 2021
Thymic stromal lymphopoietin (TSLP) is an epithelial-derived cytokine of the interleukin-2 (IL-2) cytokine family with both homeostatic and inflammatory properties in the human organism. Aberrant production of TSLP has been observed in several type 2 allergic disorders such as bronchial asthma, atopic dermatitis and allergic rhinitis, prompting the ...
Yao, Y., Ali, Z., Thomsen, S. F.
openaire   +3 more sources