Results 41 to 50 of about 152,280 (211)

Tezepelumab achieves improvement of severe uncontrolled asthma and rhinosinusitis: Case series

Journal of Allergy and Clinical Immunology: Global
Tezepelumab, a mAb targeting thymic stromal lymphopoietin (TSLP), reduces exacerbations in severe asthma. Four cases in which patients with severe asthma and chronic rhinosinusitis with nasal polyps showed improvements in both conditions after receiving ...
Shigesato Inoue, MD, Hiroaki Ogata, MD, PhD, Yoichi Dotake, MD, Koichi Takagi, MD, PhD, Ayaka Shiota, MD, Yumiko Ishii, MD, PhD, Kentaro Tanaka, MD, PhD, Keiko Kan-o, MD, PhD, Hiromasa Inoue, MD, PhD   +8 more
doaj   +1 more source

Thymic stromal lymphopoietin-stimulated CD4+ T cells induce senescence in advanced breast cancer

Frontiers in Cell and Developmental Biology, 2022
Thymic Stromal Lymphopoietin (TSLP) plays a prominent role in inducing type 2 immune response, commonly associated with atopic diseases. TSLP-activated CD4+ T helper 2 cells block early carcinogenesis by inducing terminal differentiation in spontaneous ...
Margherita Boieri, Margherita Boieri, Emanuela Marchese, Emanuela Marchese, Quan Minh Pham, Quan Minh Pham, Marjan Azin, Marjan Azin, Lauren E. Steidl, Lauren E. Steidl, Anna Malishkevich, Anna Malishkevich, Shadmehr Demehri, Shadmehr Demehri   +13 more
doaj   +1 more source

Efficacy and Predictors of Response to Biologic Therapy and Endoscopic Sinus Surgery in Patients With Nasal Polyps: A Systematic Review

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Biologics and endoscopic sinus surgery (ESS) treat refractory chronic rhinosinusitis with nasal polyposis (CRSwNP), but direct comparisons are lacking. We synthesized efficacy and subgroup data across randomized controlled trials (RCTs) of biologics and ESS.
Arun Chakravorty, Matthew E. Lin, Rory Lubner, Jess C. Mace, Jeffrey Suh, Jivianne Lee, Marilene Wang, Sarah Wise, Naweed Chowdhury, Zachary M. Soler, Justin Turner, Timothy L. Smith, Myung Sim, Daniel M. Beswick   +13 more
wiley   +1 more source

TSLP Expression: Cellular Sources, Triggers, and Regulatory Mechanisms

Allergology International, 2012
Thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine initially identified in the culture supernatant of a thymic stromal cell line. Highly expressed in the epidermis in skin lesions of atopic dermatitis patients, TSLP was subsequently found to be
Toshiro Takai
doaj   +1 more source

High‐Sugar Diet and Intestinal Diseases: A Shared Microbiota–Barrier–Immunity–Metabolism Axis in Inflammatory Bowel Disease, Food Allergy, and Colorectal Cancer

iNew Medicine, EarlyView.
ABSTRACT The global incidence of intestinal diseases—including food allergy, inflammatory bowel disease (IBD), and colorectal cancer (CRC)—continues to escalate in parallel with the expansion of the “Western diet,” within which the high‐sugar diet (HSD) has emerged as a pivotal yet under‐recognized dietary driver.
Yuchen Wang, Yajuan Wu, Huayang Sheng, Shouhong Jiang, Jinping Cheng, Ye Kuang, Miao Liu, Lei Feng, Yanan Sun, Jinzhi Duan   +9 more
wiley   +1 more source

Targeting TSLP in Asthma

Journal of Asthma and Allergy, 2022
Jane R Parnes,1 Nestor A Molfino,1 Gene Colice,2 Ubaldo Martin,2 Jonathan Corren,3 Andrew Menzies-Gow4 1Amgen, Thousand Oaks, CA, USA; 2AstraZeneca, Gaithersburg, MD, USA; 3University of California, Los Angeles, CA, USA; 4Royal Brompton and Harefield ...
Parnes JR, Molfino NA, Colice G, Martin U, Corren J, Menzies-Gow A   +5 more
doaj  

Thymic Stromal Lymphopoietin (TSLP) and Airway Smooth Muscle

The FASEB Journal, 2009
TSLP is a newly‐identified cytokine thought to be involved in airway inflammation. TSLP levels have been shown to significantly increase in airway smooth muscle (ASM) with chronic obstructive pulmonary disease and other inflammatory diseases. This study evaluated the expression of TSLP in
Dan Smelter, Michael Thompson, Lucas Meuchel, Elizabeth Townsend, Alexander Ryu, Christina Pabelick, Robert Vassallo, Y S Prakash   +7 more
openaire   +1 more source

Th2/Th17 Inflammation: Pathogenic Drivers and Therapeutic Targets in Darier and Hailey‐Hailey Diseases

JEADV Clinical Practice, EarlyView.
Skin samples of Hailey‐Hailey and Darier diseases were analyzed for inflammatory and barrier markers using indirect immunofluorescence and transcriptomic techniques. A mixed Th2/Th17 inflammatory pattern and altered expression of barrier markers were observed.
Ella Glodjajic, Darko Stojkov, Joanna Boros‐Majewska, Jeremy Di Domizio, Michel Gilliet, Christoph Schlapbach, Timothée Fettrelet, Luca Borradori, Hans‐Uwe Simon, Dagmar Simon, Susanne Radonjic‐Hoesli   +10 more
wiley   +1 more source

Early Growth Response 1‐Associated Epithelial Autophagy‐Related Changes in Allergic Airway Inflammation

Pediatric Discovery, EarlyView.
House dust mite (HDM) exposure induces early growth response 1 (EGR1) expression in airway epithelial cells and is accompanied by autophagy‐associated alterations, including increased LC3B‐II and Vps34 levels and decreased p62 abundance. Manipulation of EGR1 expression modulates these autophagy‐related changes, whereas pharmacological inhibition of ...
Xinyang Wang, Jie Ren, Yan Zhao, Zhengxiu Luo   +3 more
wiley   +1 more source

The last step to achieve barrier damage control

Frontiers in Immunology
Heterogeneity characterises inflammatory diseases and different phenotypes and endotypes have been identified. Both innate and adaptive immunity contribute to the immunopathological mechanism of these diseases and barrier damage plays a prominent role ...
Ilaria Baglivo, Stefania Colantuono, Arianna Lumaca, Alfredo Papa, Antonio Gasbarrini, Cristiano Caruso   +5 more
doaj   +1 more source