Results 51 to 60 of about 152,280 (211)

Thymic Stromal Lymphopoietin Over-Expressed in Human Atherosclerosis: Potential Role in Th17 Differentiation

Cellular Physiology and Biochemistry, 2013
Background: Adaptive immunity plays a critical role in atherosclerosis and T helper 17 (Th17) cells, a new T-cell lineage, are recently reported to be involved in atherosclerosis.
Jing Lin, Wei Chang, Jiangchuan Dong, Fengxiao Zhang, Nilesh Mohabeer, Kishan Kumar Kushwaha, Lei Wang, Yousu Su, Hongcheng Fang, Dazhu Li   +9 more
doaj   +1 more source

Atopic dermatitis and attention‐deficit/hyperactivity disorder comorbidity in children and adolescents: Epidemiology, mechanisms, and clinical management

Pediatric Investigation, EarlyView.
This review synthesizes epidemiological evidence linking atopic dermatitis to attention‐deficit/hyperactivity disorder in children, proposes an “inflammation‐itch‐neurobehavioral axis” integrating sleep disruption, neuroendocrine dysregulation, and emerging neuro‐immune circuits, and outlines multidisciplinary management strategies targeting both skin ...
Qingyang Zhao, Yuan Liang, Ying Liu, Chunping Shen, Mutong Zhao, Jing Tian, Lei Jiao, Jing Sun, Ying Gu, Qiong Wu, Shan Wang, Lin Ma   +11 more
wiley   +1 more source

Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation [PDF]

Leukemia, 2001
Thymic stromal lymphopoietin (TSLP) is a novel cytokine that was found to promote the development of murine B cells in vitro. Here we describe the cloning and characterization of the human homologue of murine TSLP. This protein, which is expressed in a number of tissues including heart, liver and prostate, prevented apoptosis and stimulated growth of ...
H, Quentmeier, H G, Drexler, D, Fleckenstein, M, Zaborski, A, Armstrong, J E, Sims, S D, Lyman   +6 more
openaire   +2 more sources

Relationship between meconium staining and thymic stromal lymphopoietin

, 2014
OBJECTIVE: Epithelium-derived thymic stromal lymphopoietin (TSLP), is a key pro-allergic cytokine that has recently been linked to chronic airway diseases.
Mollamahmutoglu, L., Engin-Ustun, Y., Yenicesu, O., Demirtas, CANAN, Ozkan, M. S., Eyi, E. G. Y., Aktulay, A.   +6 more
core   +1 more source

Interleukin-7 Receptor Alpha in Innate Lymphoid Cells: More Than a Marker

Frontiers in Immunology, 2019
Innate lymphoid cells (ILCs) are a group of immune cells that are important for defense against pathogens, tissue repair, and lymphoid organogenesis.
Abdalla Sheikh, Abdalla Sheikh, Ninan Abraham, Ninan Abraham, Ninan Abraham   +4 more
doaj   +1 more source

Detection and Inhalation Hazard Assessment of Wear Particles Arising From Abrasion of Market‐relevant Graphene Reinforced Composites

Small, EarlyView.
Abrasion of few‐layer graphene (FLG)–epoxy composites generated respirable particles in which FLG remained fully embedded, as confirmed by correlative HR‑TEM, Raman, and ToF‑SIMS analyses. Advanced lung cell models revealed no cytotoxic or inflammatory responses, and only high‑dose epoxy particles reduced mucociliary clearance.
Govind Gupta, Jimmy Vernaz, Antje Vennemann, Maike Stange, Asmus Meyer‐Plath, Servane Contal, Sarah Zehnder, Ziting Wang, Aline Chary, Stephanie Eitner, Philipp Mueller, Vera M. Kissling, Samuel Constant, Lucie Chupin, Daniel Breitenstein, Birgit Hagenhoff, Tommaso Serchi, Bernadett Boda, Martin Wiemann, Peter Wick, Tina Buerki‐Thurnherr   +20 more
wiley   +1 more source

Molecular cloning and characterization of equine thymic stromal lymphopoietin

, 2010
Thymic stromal lymphopoietin (TSLP) is a novel cytokine that plays a central role in T helper 2 (Th2) cell differentiation and allergic inflammation.
Klukowska-Rötzler, Jolanta, Leeb, Tosso, Marti, Eliane Isabelle, Bugno, M., Janda, Jozef, Klukowska, Jolanta, Bugno M, Leeb T, Marti E, Klukowska-Rötzler J, Janda J, E. Marti, J. Janda, T. Leeb, J. Klukowska-Rötzler, M. Bugno   +15 more
core   +1 more source

Integrative Analysis of Plasma Proteome and Genome Reveals Novel Drug Targets for Chronic Rhinosinusitis and Nasal Polyps

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) and nasal polyps (NP) are chronic inflammatory conditions with unsatisfactory treatment outcomes due to frequent recurrence of refractory disease. Identifying new therapeutic targets is essential. Methods We conducted a proteome‐wide Mendelian randomization (MR) analysis by integrating genome‐wide ...
En Zhou, Shi Luo, Yu Xiao, Bin Liu, Xu‐Ping Xiao   +4 more
wiley   +1 more source

The multiple facets of thymic stromal lymphopoietin (TSLP) during allergic inflammation and beyond [PDF]

Journal of Leukocyte Biology, 2012
ABSTRACTOriginally shown to promote the growth and activation of B cells, TSLP is now known to have wide-ranging impacts on hematopoietic and nonhematopoietic cell lineages, including DCs, basophils, eosinophils, mast cells, CD4+, CD8+, and NK T cells, B cells, and epithelial cells.
Florence, Roan, Bryan D, Bell, Thomas A, Stoklasek, Masayuki, Kitajima, Hongwei, Han, Steven F, Ziegler   +5 more
openaire   +2 more sources

Serotonin Degradation and Lipid Metabolism Regulate Human Tc2 Cell Effector Functions

Allergy, EarlyView.
Human Tc2 cells exhibit a metabolically active phenotype characterized by enhanced glycolysis, mitochondrial respiration, and fatty acid uptake dependent on PPARγ. Alarmins strongly amplify IL‐5 and IL‐13 production in Tc2 cells, supporting a shared immunometabolic program across type 2 lymphocytes.
Sabrina de Souza Ferreira, Lisa Holla, Sophia Björkander, Marie Kaarup Bek, Lorenz Wirth, Patrick A. Shearer, Jesper Säfholm, Erik Sachs, Mamdoh Al‐Ameri, Kasra Vali, Sandra Ekström, Erik Melén, Jenny Mjösberg, Christopher Andrew Tibbitt   +13 more
wiley   +1 more source