Results 71 to 80 of about 8,456 (180)

Emerging Paediatric Uses of Dupilumab Beyond Approvals

Clinical &Experimental Allergy, EarlyView.
Dupilumab, through IL‐4Rα blockade, shows promising efficacy beyond approved indications in paediatric diseases driven by T2 inflammation. Emerging evidence—mainly from small studies—supports improvements in disease severity and quality of life, highlighting its potential as a targeted, steroid‐sparing therapy while underscoring the need for ...
Simone Foti Randazzese, Anna Calamita, Diletta D'Angelo, Alessia Marseglia, Esther Mesa Lombardero, Sara Pedersoli, Micol Tedeschi, Mara De Amici, Sara Manti, Valeria Brazzelli, Amelia Licari, Gian Luigi Marseglia   +11 more
wiley   +1 more source

Cellular and Molecular Mechanisms of TSLP Function in Human Allergic Disorders - TSLP Programs the “Th2 code” in Dendritic Cells

Allergology International, 2012
Thymic stromal lymphopoietin (TSLP) has been recently implicated as a key molecule for initiating allergic inflammation at the epithelial cell-dendritic cell (DC) interface.
Tomoki Ito, Yong-Jun Liu, Kazuhiko Arima
doaj   +1 more source

Inflammatory Mediators Associated With Corticosteroid Responsiveness During Asthma Attacks

Clinical &Experimental Allergy, EarlyView.
ABSTRACT Higher baseline sputum/serum eotaxin‐3 and serum IL‐5 levels were associated with greater FEV1 improvement following OCS during asthma attacks. Corticosteroid‐induced inflammatory modulation differed across T2 phenotypes during asthma attacks.
Carlos Celis‐Preciado, Elsa Ben Hamou Kuijpers, Mohamed‐Ilias Kourid, Simon Leclerc, Martine Duval, Dominic O. Cliche, Félix‐Antoine Vézina, Pierre Larivée, Samuel Lemaire‐Paquette, Philippe Lachapelle, Martin Klein, Simon Couillard   +11 more
wiley   +1 more source

A Distinct Sensitization Pattern Associated with Asthma and the Thymic Stromal Lymphopoietin (TSLP) Genotype

Allergology International, 2013
Atopy is a phenotypically heterogeneous condition, and the extent to which atopy accounts for asthma is controversial. In this study, we aimed to identify the presence of distinct sensitization patterns to common inhaled allergens and their association with asthma, allergic rhinitis and TSLP genotypes.We studied 1683 adults from Tsukuba, a city in ...
Iijima, Hiroaki, Kaneko, Yoshiko, Yamada, Hideyasu, Yatagai, Yohei, Masuko, Hironori, Sakamoto, Tohru, Naito, Takashi, Hirota, Tomomitsu, Tamari, Mayumi, Konno, Satoshi, Nishimura, Masaharu, Noguchi, Emiko, Hizawa, Nobuyuki   +12 more
openaire   +3 more sources

Andrographolide suppresses thymic stromal lymphopoietin in phorbol myristate acetate/calcium ionophore A23187-activated mast cells and 2,4-dinitrofluorobenzene-induced atopic dermatitis-like mice model

Drug Design, Development and Therapy, 2016
Chun-xiao Li,* Hua-guo Li,* Hui Zhang,* Ru-hong Cheng, Ming Li, Jian-ying Liang, Yan Gu, Bo Ling, Zhi-rong Yao, Hong Yu Department of Dermatology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of ...
Li CX, Li HG, Zhang H, Cheng RH, Li M, Liang JY, Gu Y, Ling B, Yao ZR, Yu H   +9 more
doaj  

IL-17A-associated IKK-α signaling induced TSLP production in epithelial cells of COPD patients

Experimental and Molecular Medicine, 2018
Lung disease: inflammatory proteins implicated in chronic obstructive pulmonary disease Two proteins involved in the maturation of immune cells contribute to the inflammation responsible for chronic obstructive pulmonary disease (COPD) and could thus ...
Giulia Anzalone, Giusy Daniela Albano, Angela Marina Montalbano, Loredana Riccobono, Anna Bonanno, Rosalia Gagliardo, Fabio Bucchieri, Roberto Marchese, Monica Moscato, Mirella Profita   +9 more
doaj   +1 more source

Oral PHGG ameliorates atopic dermatitis‐like dermatitis with concurrent modulation of colonic IgA and cecal microbiota: implications for the gut–skin axis

Journal of the Science of Food and Agriculture, Volume 106, Issue 11, Page 6380-6394, 30 August 2026.
Abstract BACKGROUND Atopic dermatitis (AD) is increasingly recognized as a systemic inflammatory disorder linked to intestinal immune and microbiome dysregulation. However, whether dietary galactomannan fibers can mitigate AD through coordinated modulation of the gut–skin axis remains unexplored.
Derrick Kakooza, Hyeonjun Yu, Jonghyun Jeong, Jung Cheul Shin, Woo Jung Kim, Sung‐Kwon Moon, Hoon Kim   +6 more
wiley   +1 more source

Thymic stromal lymphopoietin (TSLP) – pro-inflammatory cytokine and antimicrobial peptide

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine primarily produced by epithelial cells. It functions as a key regulator of immune responses, especially at barrier surfaces such as the skin, gut, and respiratory tract. Humans express two forms of TSLP: long-form TSLP (lfTSLP), which acts as a pro-inflammatory cytokine, and short-form TSLP (
Katinka, Döhner, Ojonugwa Precious, John, Thomas, Werfel   +2 more
openaire   +2 more sources

Systemic Corticosteroids in the Management of Sinonasal Disease: An Evidence‐Based Expert Review

International Forum of Allergy &Rhinology, Volume 16, Issue 8, Page 852-879, August 2026.
ABSTRACT Background Chronic rhinosinusitis (CRS) is a prevalent, heterogeneous inflammatory disease associated with significant morbidity. Systemic corticosteroids (SCS) are commonly prescribed for their anti‐inflammatory effects, but cumulative exposure carries risks, including metabolic, cardiovascular, and skeletal complications.
Andrew Thamboo, Deanna Gigliotti, Eugenio De Corso, Stella Lee, Benjamin S. Bleier, Christopher J. Chin, Marie‐Noelle Corriveau, Valerie Hox, Claire Hopkins, Peter H. Hwang, Arif Janjua, Ludger Klimek, Daniel Lee, John Lee, Amber Luong, Geoffrey Mortuaire, Joaquim Mullol, Zara M. Patel, John Scott, Doron Sommer, Leigh Sowerby, Marc Tewfik, Beatrice Voizard, Martin Wagenmannm, Sarah K. Wise, Jonathan Yip, Quirina Thompson, Martin Desrosiers, Yvonne Chan   +28 more
wiley   +1 more source

S100A alarmins and thymic stromal lymphopoietin (TSLP) regulation in severe asthma following bronchial thermoplasty. [PDF]

Respir Res, 2023
Gagnon PA, Klein M, De Vos J, Biardel S, Côté A, Godbout K, Laviolette M, Laprise C, Assou S, Chakir J.   +9 more
europepmc   +1 more source