Results 71 to 80 of about 139,364 (204)

Understanding the Type 2 Immunity: An Evolving View Beyond Allergic Diseases

Allergy, EarlyView.
ABSTRACT Type 2 (T2) immunity is classically associated with defense against helminths and environmental threats, from a physiological perspective, and with allergies and eosinophilic inflammatory diseases, in a pathological sense. However, growing evidence reveals that T2 pathways also support other essential homeostatic functions, including tissue ...
Rodrigo Jiménez‐Saiz, Salvador Iborra, Carlos Blanco, Ruperto González‐Pérez, Emilio Nuñez‐Borque, Can Zeyneloglu, Huseyn Babayev, Ozlem Göksel, Tuncay Göksel, Musa Khaitov, Dmitry Kudlay, Yadong Gao, Mustafa Sevim, Marie‐Charlotte Brüggen, Oral Alpan, Ming Wang, Luo Zhang, María J. Torres, Mohamed Shamji, Mübeccel Akdis, Kari C. Nadeau, Ismail Ogulur, Cezmi A. Akdis   +22 more
wiley   +1 more source

Emerging Paediatric Uses of Dupilumab Beyond Approvals

Clinical &Experimental Allergy, EarlyView.
Dupilumab, through IL‐4Rα blockade, shows promising efficacy beyond approved indications in paediatric diseases driven by T2 inflammation. Emerging evidence—mainly from small studies—supports improvements in disease severity and quality of life, highlighting its potential as a targeted, steroid‐sparing therapy while underscoring the need for ...
Simone Foti Randazzese, Anna Calamita, Diletta D'Angelo, Alessia Marseglia, Esther Mesa Lombardero, Sara Pedersoli, Micol Tedeschi, Mara De Amici, Sara Manti, Valeria Brazzelli, Amelia Licari, Gian Luigi Marseglia   +11 more
wiley   +1 more source

Upregulated thymic stromal lymphopoietin receptor expression in children with asthma

, 2017
Background Thymic stromal lymphopoietin (TSLP) plays an important role in pathogenesis in patients with asthma. However, the role of thymic stromal lymphopoietin receptor (TSLPR) and correlation with IL-7R alpha and clinical severity in asthmatic or ...
江伯倫, Lin, Sheng-Chieh;Huang, Jian-Jhang;Wang, Jiu-Yao;Chuang, Hsiao-Chi;Chiang, Bor-Luen;Ye, Yi-Ling   +1 more
core   +1 more source

Targeting thymic stromal lymphopoietin in nasal type 2 inflammation

Eye & ENT Research
Epithelial cell‐derived thymic stromal lymphopoietin (TSLP) plays a crucial role in mediating type 2 immune responses, which is one of the key underlying pathophysiological mechanisms of allergic rhinitis (AR) and most presentations of chronic ...
Xintong Li, Jingjing Guo, Jing Song, Ming Wang   +3 more
doaj   +1 more source

TSLP promoting B cell proliferation and polarizing follicular helper T cell as a therapeutic target in IgG4-related disease

Journal of Translational Medicine, 2022
Objective To figure out the functions of thymic stromal lymphopoietin (TSLP) in IgG4-related disease (IgG4-RD). Methods Plasma TSLP levels were tested by Elisa, and its receptors were detected by flow cytometry.
Hui Lu, Xunyao Wu, Yu Peng, Ruijie Sun, Yuxue Nie, Jingna Li, Mu Wang, Yaping Luo, Linyi Peng, Yunyun Fei, Jiaxin Zhou, Wen Zhang, Xiaofeng Zeng   +12 more
doaj   +1 more source

Inflammatory Mediators Associated With Corticosteroid Responsiveness During Asthma Attacks

Clinical &Experimental Allergy, EarlyView.
ABSTRACT Higher baseline sputum/serum eotaxin‐3 and serum IL‐5 levels were associated with greater FEV1 improvement following OCS during asthma attacks. Corticosteroid‐induced inflammatory modulation differed across T2 phenotypes during asthma attacks.
Carlos Celis‐Preciado, Elsa Ben Hamou Kuijpers, Mohamed‐Ilias Kourid, Simon Leclerc, Martine Duval, Dominic O. Cliche, Félix‐Antoine Vézina, Pierre Larivée, Samuel Lemaire‐Paquette, Philippe Lachapelle, Martin Klein, Simon Couillard   +11 more
wiley   +1 more source

Trans‐resveratrol alleviates inflammation and improves skin barrier function via aryl hydrocarbon receptor pathway in human reconstructed epidermis

International Journal of Cosmetic Science, EarlyView.
In a cytokine‐challenged human epidermal model, trans‐resveratrol reduces inflammation (IL‐1α) and oxidative stress markers (CYP1A1, CYP1B1), while modulating the expression of barrier‐related genes (LOR, OCLN) and differentiation‐associated CASP14. This supports its role as a multifunctional active for sensitive and compromised skin.
Irini M. Dijkhoff, Sandeep Keshavan, Regina G. Daré, Alke Petri‐Fink, Marc Eeman, Agnès Tessier, Barbara Rothen‐Rutishauser   +6 more
wiley   +1 more source

Thymic stromal lymphopoietin in leukemia: A double-edged sword?

Leukemia Research Reports
Thymic stromal lymphopoietin (TSLP) is a cytokine expressed by various cell types. It is involved in the development of allergies, autoimmune diseases, and cancers.
Xing Zou, Mengmeng Gu, Yue Su, Dayong Yao, Hao Gang, Yang Li, Ce Shi   +6 more
doaj   +1 more source

Microbial and host‐derived biomarkers for the diagnosis and management of peri‐implant diseases

Periodontology 2000, EarlyView.
Abstract Objectives To critically evaluate the current evidence on microbial and host‐derived biomarkers for the diagnosis and management of peri‐implant diseases, with emphasis on their biological relevance, potential clinical utility, and current translational limitations.
Su Sheng Quach, Ausra Ramanauskaite, Sašo Ivanovski, Pingping Han, Frank Schwarz, Emilio A. Cafferata   +5 more
wiley   +1 more source

Therapeutic potential of a Bax inhibitor‐1/TMBIM6 antagonist (BIA) and its analogues in Aspergillus fumigatus‐induced asthma via dual targeting of AKT and epithelial‐derived inflammatory cytokines

British Journal of Pharmacology, Volume 183, Issue 19, Page 5975-5991, October 2026.
Background and Purpose Aspergillus fumigatus (A. fumigatus) exposure causes of severe allergic asthma, characterized by airway inflammation and epithelial dysfunction. TMBIM6 (Bax inhibitor‐1) has been implicated in airway epithelial stress responses and AKT signalling.
Young‐Jin Yu, Ahsan Ullah, Jisun Kim, Mehedi Hasan Bappi, Yerim Heo, Jin Hee Ahn, Hyun‐Kyoung Kim, Han‐Jung Chae   +7 more
wiley   +1 more source