Results 91 to 100 of about 152,280 (211)

Microbial and host‐derived biomarkers for the diagnosis and management of peri‐implant diseases

Periodontology 2000, EarlyView.
Abstract Objectives To critically evaluate the current evidence on microbial and host‐derived biomarkers for the diagnosis and management of peri‐implant diseases, with emphasis on their biological relevance, potential clinical utility, and current translational limitations.
Su Sheng Quach, Ausra Ramanauskaite, Sašo Ivanovski, Pingping Han, Frank Schwarz, Emilio A. Cafferata   +5 more
wiley   +1 more source

A Distinct Sensitization Pattern Associated with Asthma and the Thymic Stromal Lymphopoietin (TSLP) Genotype

Allergology International, 2013
Atopy is a phenotypically heterogeneous condition, and the extent to which atopy accounts for asthma is controversial. In this study, we aimed to identify the presence of distinct sensitization patterns to common inhaled allergens and their association with asthma, allergic rhinitis and TSLP genotypes.We studied 1683 adults from Tsukuba, a city in ...
Iijima, Hiroaki, Kaneko, Yoshiko, Yamada, Hideyasu, Yatagai, Yohei, Masuko, Hironori, Sakamoto, Tohru, Naito, Takashi, Hirota, Tomomitsu, Tamari, Mayumi, Konno, Satoshi, Nishimura, Masaharu, Noguchi, Emiko, Hizawa, Nobuyuki   +12 more
openaire   +3 more sources

IL-17A-associated IKK-α signaling induced TSLP production in epithelial cells of COPD patients

Experimental and Molecular Medicine, 2018
Lung disease: inflammatory proteins implicated in chronic obstructive pulmonary disease Two proteins involved in the maturation of immune cells contribute to the inflammation responsible for chronic obstructive pulmonary disease (COPD) and could thus ...
Giulia Anzalone, Giusy Daniela Albano, Angela Marina Montalbano, Loredana Riccobono, Anna Bonanno, Rosalia Gagliardo, Fabio Bucchieri, Roberto Marchese, Monica Moscato, Mirella Profita   +9 more
doaj   +1 more source

Cellular and Molecular Mechanisms of TSLP Function in Human Allergic Disorders - TSLP Programs the “Th2 code” in Dendritic Cells

Allergology International, 2012
Thymic stromal lymphopoietin (TSLP) has been recently implicated as a key molecule for initiating allergic inflammation at the epithelial cell-dendritic cell (DC) interface.
Tomoki Ito, Yong-Jun Liu, Kazuhiko Arima
doaj   +1 more source

Cancer‐associated fibroblast heterogeneity across solid and haematological malignancies: Lessons from colorectal cancer and multiple myeloma

The Journal of Physiology, EarlyView.
Abstract figure legend CAF origins and plasticity give rise to distinct phenotypes with immunosuppressive functions in colorectal cancer and multiple myeloma. These distinct CAF phenotypes contribute to immunosuppressive tumour microenvironments through ECM remodelling, cytokine signalling and immune regulation.
Hui Mo, Haoyan Han, Michael O'Dwyer, Eileen Reidy, Aideen E. Ryan   +4 more
wiley   +1 more source

Thymic stromal lymphopoietin (TSLP) – pro-inflammatory cytokine and antimicrobial peptide

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine primarily produced by epithelial cells. It functions as a key regulator of immune responses, especially at barrier surfaces such as the skin, gut, and respiratory tract. Humans express two forms of TSLP: long-form TSLP (lfTSLP), which acts as a pro-inflammatory cytokine, and short-form TSLP (
Katinka, Döhner, Ojonugwa Precious, John, Thomas, Werfel   +2 more
openaire   +2 more sources

Thymic stromal lymphopoietin is expressed in the intact central nervous system and upregulated in the myelin‐degenerative central nervous system

, 2014
Thymic stromal lymphopoietin (TSLP) is an epithelial cytokine expressed at barrier surfaces of the skin, gut, nose, lung, and the maternal/fetal interphase.
Isabella Wimmer, Antonia Rudel, Kitic, M, Lassmann, H, Monika Bradl, Adzemovic, M, Bradl, M, Milena Adzemovic, Maja Kitic, Kögl, N, Nikolaus Kögl, Rudel, A, Wimmer, I, Hans Lassmann   +13 more
core   +1 more source

Pharmacokinetics and safety of tezepelumab in children with mild, moderate or severe asthma and adolescents with mild‐to‐moderate asthma

British Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 3819-3830, November 2026.
Abstract Aim Tezepelumab is a human monoclonal antibody that blocks the activity of thymic stromal lymphopoietin and is approved for adolescents and adults with severe asthma. This analysis assessed pharmacokinetics (PK), pharmacodynamics and safety of tezepelumab up to 85 days postdose in adolescents and children.
Anna Lundahl, Jonathan Grigg, Lubna Abuqayyas, Piotr Kuna, Gillian Hunter, Beata Pawlikowska, Jacob Leander, Michael Levin, Atul Gupta, James Paton, Katharine C. Pike, Jane R. Parnes, Gun Almqvist, Stephanie L. Roseti, on behalf of the study investigators   +14 more
wiley   +1 more source

S100A alarmins and thymic stromal lymphopoietin (TSLP) regulation in severe asthma following bronchial thermoplasty. [PDF]

Respir Res, 2023
Gagnon PA, Klein M, De Vos J, Biardel S, Côté A, Godbout K, Laviolette M, Laprise C, Assou S, Chakir J.   +9 more
europepmc   +1 more source

Adaptive Immunity in Marsupials

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, Volume 345, Issue 9, Page 913-932, November 2026.
Comparison of the marsupial and eutherian adaptive immune systems. ABSTRACT Marsupials diverged from eutherian mammals 125–160 million years ago. Although evolutionarily distinct, both groups of mammals can produce complex adaptive immune responses to antigens with several key differences.
Cassandra L. Jol, Hayley J. Stannard, Julie M. Old   +2 more
wiley   +1 more source