Results 61 to 70 of about 139,364 (204)

The multiple facets of thymic stromal lymphopoietin (TSLP) during allergic inflammation and beyond [PDF]

Journal of Leukocyte Biology, 2012
ABSTRACTOriginally shown to promote the growth and activation of B cells, TSLP is now known to have wide-ranging impacts on hematopoietic and nonhematopoietic cell lineages, including DCs, basophils, eosinophils, mast cells, CD4+, CD8+, and NK T cells, B cells, and epithelial cells.
Florence, Roan, Bryan D, Bell, Thomas A, Stoklasek, Masayuki, Kitajima, Hongwei, Han, Steven F, Ziegler   +5 more
openaire   +2 more sources

Emollient Formulations and Skin Barrier Practices in the Context of Eczema and Food Allergy Prevention

Allergy, EarlyView.
ABSTRACT The skin is far from a passive shield; it functions as a dynamic “living barrier” whose structural and immunological integrity is paramount in preventing atopic dermatitis (AD) and the subsequent progression of the atopic march toward food allergy (FA).
Klaudia Ryczaj, Donald Y. M. Leung, Carina Venter, Barbara Sozańska, Helen A. Brough   +4 more
wiley   +1 more source

Thymic stromal lymphopoietin (TSLP)-mediated dermal inflammation aggravates experimental asthma [PDF]

Mucosal Immunology, 2012
Individuals with one atopic disease are far more likely to develop a second. Approximately half of all atopic dermatitis (AD) patients subsequently develop asthma, particularly those with severe AD. This association, suggesting a role for AD as an entry point for subsequent allergic disease, is a phenomenon known as the "atopic march." Although the ...
Han, Hongwei, Xu, Whitney, Headley, Mark B., Jessup, Heidi K., Lee, Karen S., Omori, Miyuki, Comeau, Michael R., Marshak-Rothstein, Ann, Ziegler, Steven F.   +8 more
openaire   +2 more sources

Microbiota Signatures in Early Life and Their Association With Food Allergy: A Systematic Review

Allergy, EarlyView.
ABSTRACT Food allergy (FA) is increasing worldwide, and early life may be a critical window for immune training. We systematically reviewed observational human studies linking early‐life microbiota (infant, maternal, environmental, or extraintestinal) profiled using culture‐based and/or culture‐independent methods (including sequencing‐based approaches)
Eduard Flores Ventura, Jeremy Corriger, Hélène Omer, Marie Bodinier, Dirk Haller, Tomer Hertz, Martin Larsen, Maria Carmen Collado   +7 more
wiley   +1 more source

Thymic stromal lymphopoietin levels after allogeneic hematopoietic stem cell transplantation

, 2022
Background: Thymic stromal lymphopoietin (TSLP) is an immunoregulatory, Th2-polarizing cytokine produced by epithelial cells. We hypothesized that TSLP affects immune reconstitution after hematopoietic stem cell transplantation (HSCT) leading to ...
Lars Peter Ryder, Dina Leth Møller, Ryder, Lars Peter, Pedersen, Anders Elm, Müller, Klaus, Claus Henrik Nielsen, Katrine Kielsen, Kielsen, Katrine, Anders Elm Pedersen, Klaus Müller, Sengeløv, Henrik, Henrik Sengeløv, Møller, Dina Leth, Nielsen, Claus Henrik   +13 more
core   +1 more source

TSLP/dendritic cell axis promotes CD4+ T cell tolerance to the gut microbiome

JCI Insight, 2023
Thymic stromal lymphopoietin (TSLP) overexpression is widely associated with atopy. However, TSLP is expressed in normal barrier organs, suggesting a homeostatic function.
Jonathan L. Messerschmidt, Marjan Azin, Kaitlin E. Dempsey, Shadmehr Demehri   +3 more
doaj   +1 more source

Basophils in Immunity: Activation Pathways, Roles in Allergy and AllergoOncology and Application of the Basophil Activation Test

Allergy, EarlyView.
ABSTRACT Basophils, the least abundant leukocytes, are increasingly recognised as potent immunomodulators. Upon activation, they rapidly release preformed granule‐associated mediators including histamine and lipid mediators such as LTC4, while cytokine production occurs over a longer timescale, contributing to downstream immune responses.
Jitesh Chauhan, Sofia Vlasova, Alicia Chenoweth, Debra H. Josephs, Heather J. Bax, Sophia N. Karagiannis   +5 more
wiley   +1 more source

Dendritic Cell-Derived TSLP Negatively Regulates HIF-1α and IL-1β During Dectin-1 Signaling

Frontiers in Immunology, 2019
Thymic stromal lymphopoietin (TSLP) is a functionally pleotropic cytokine important in immune regulation, and TSLP dysregulation is associated with numerous diseases.
Matthew J. Elder, Matthew J. Elder, Steve J. Webster, Steve J. Webster, Timothy J. Fitzmaurice, Aran S. D. Shaunak, Martin Steinmetz, Ronnie Chee, Ziad Mallat, E. Suzanne Cohen, David L. Williams, J. S. Hill Gaston, Jane C. Goodall   +12 more
doaj   +1 more source

Expression of Thymic Stromal Lymphopoietin in Immune-Related Dermatoses

Mediators of Inflammation, 2022
Thymic stromal lymphopoietin (TSLP), long known to be involved in Th2 response, is also implicated in multiple inflammatory dermatoses and cancers. The purpose of this study was to improve our understanding of the expression of TSLP in the skin of those ...
Si-Zhe Li, Xin-Xing Jin, Yin Shan, Hong-Zhong Jin, Ya-Gang Zuo   +4 more
doaj   +1 more source

Serum‐Proteomic Profiling Reveals Distinct Atopic Dermatitis Severity‐Linked Signatures

Allergy, EarlyView.
This study aimed to identify a set of serum biomarkers that robustly distinguish prespecified severe from mild atopic dermatitis groups. Serum proteomic profiling distinguishes severe from mild atopic dermatitis, revealing an epithelial enriched severity footprint linked to LDH‐associated tissue injury and Th2/Th22 inflammation.
Jag S. Lally, Takeshi Yoshida, Shan Gao, Xueya Cai, Donald Y. M. Leung, Lisa A. Beck, Anna De Benedetto   +6 more
wiley   +1 more source