The Role of Thymic Stromal Lymphopoietin (TSLP) in Glomerulonephritis [PDF]
Childhood Kidney Diseases, 2018 Thymic stromal lymphopoietin (TSLP) is an interleukin-7-like cytokine that is an important trigger and initiator of many allergic diseases. TSLP promotes a T-helper type 2 (Th2) cytokine response that can be pathological. A relationship is formed both at
Keum Hwa Lee +8 more
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Allergology International, 2012 Thymic stromal lymphopoietin (TSLP) has been recently implicated as a key molecule for initiating allergic inflammation at the epithelial cell-dendritic cell (DC) interface.
Tomoki Ito, Yong-Jun Liu, Kazuhiko Arima
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Achieving clinical and histologic remission with tezepelumab in an adolescent with refractory eosinophilic gastrointestinal disease: A case report [PDF]
JPGN Reports, EarlyView.Abstract Tezepelumab is a human monoclonal antibody that binds to human thymic stromal lymphopoietin (TSLP), an epithelial cytokine that plays a role in Type 2 signaling. We describe a 17‐year‐old with a history of eosinophilic esophagitis (EoE) and eosinophilic gastroenteritis who demonstrated response to tezepelumab with both clinical and histologic ...
Destiny Newsome +3 more
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Role of the TSLP and its Receptor in the Treatment of Asthma
Barcelona Respiratory Network Reviews, 2023 Thymic stromal lymphopoietin (TSLP) is a crucial cytokine in initiating and regulating immune responses. Various cell types, including epithelial cells, fibroblasts, and dendritic cells, synthesize TSLP. TSLP activates dendritic cells, which subsequently
Miguel Estravís +2 more
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Cellular Physiology and Biochemistry, 2015 Aims: Thymic stromal lymphopoietin (TSLP) plays an important role in inflammatory diseases and is over-expressed in human atherosclerotic artery specimens.
Jangchuan Dong +10 more
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TSLP is involved in expansion of early thymocyte progenitors [PDF]
BMC Immunology, 2007 Background Thymic stromal derived lymphopoietin (TSLP) is preferentially and highly expressed in the thymus, but its function in T cell development is not clear.
Coffield V McNeil +3 more
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TSLP directly impairs pulmonary Treg function: association with aberrant tolerogenic immunity in asthmatic airway [PDF]
Allergy, Asthma & Clinical Immunology, 2010 Background Even though thymic stromal lymphopoietin (TSLP) has been implicated in the development of allergic inflammation, its influence on immune tolerance mediated by regulatory T cells (Treg) have not been explored.
Nguyen Khoa D +2 more
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MERS-CoV Infection and Its Impact on the Expression of TSLP Cytokine and IgG Antibodies: An In Vivo and In Vitro Study [PDF]
Infection and Drug ResistanceAyman Mubarak,1 Mahfoudh Alqoufail,1 Saeedah Almutairi,1 Bahauddeen Alrfaei,2 Abdulaziz Almotairi,3 Ibrahim Aziz,1 Taghreed N Almanaa,1 Mostafa A Abdel-Maksoud,1 Mohamed A Farrag,1 Allolo D Aldreiwish,4 Maaweya E Awadalla,5 Bandar Alosaimi,5 Wael ...
Mubarak A +12 more
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Intestinal bacteria induce TSLP to promote mutualistic T-cell responses [PDF]
, 2013 Thymic stromal lymphopoietin (TSLP) is constitutively expressed in the intestine and is known to regulate inflammation in models of colitis. We show that steady-state TSLP expression requires intestinal bacteria and has an important role in limiting the ...
Massacand, Jonathan +21 more
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Characterization of the function of thymic stromal lymphopoietin in lymphopoiesis and lymph node organogenesis [PDF]
, 2010 Interleukin (IL)-7 is a cytokine, which is crucial for the development of the murine immune system. It is required for lymphopoiesis and for the development of peripheral lymph nodes (LN). IL-7-/-mice have impaired B and T cell lymphopoiesis, decreased
Chappaz, Stéphane
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