Results 11 to 20 of about 16,704 (236)

TSLP signaling pathway map: a platform for analysis of TSLP-mediated signaling [PDF]

Database, 2014
Thymic stromal lymphopoietin (TSLP) is a four-helix bundle cytokine that plays a critical role in the regulation of immune responses and in the differentiation of hematopoietic cells. TSLP signals through a heterodimeric receptor complex consisting of an interleukin-7 receptor α chain and a unique TSLP receptor (TSLPR) [also known as cytokine receptor ...
Jun Zhong, Jyoti Sharma, Rajesh Raju, Shyam Mohan Palapetta, T. S. Keshava Prasad, Tai-Chung Huang, Akinori Yoda, Jeffrey W. Tyner, Diederik van Bodegom, David M. Weinstock, Steven F. Ziegler, Akhilesh Pandey   +11 more
openaire   +7 more sources

TSLP and Immune Homeostasis [PDF]

Allergology International, 2012
In an immune system, dendritic cells (DCs) are professional antigen-presenting cells (APCs) as well as powerful sensors of danger signals. When DCs receive signals from infection and tissue stress, they immediately activate and instruct the initiation of appropriate immune responses to T cells.
Shino Hanabuchi, Norihiko Watanabe, Yong-Jun Liu   +2 more
openaire   +4 more sources

The Role of Thymic Stromal Lymphopoietin (TSLP) in Glomerulonephritis [PDF]

Childhood Kidney Diseases, 2018
Thymic stromal lymphopoietin (TSLP) is an interleukin-7-like cytokine that is an important trigger and initiator of many allergic diseases. TSLP promotes a T-helper type 2 (Th2) cytokine response that can be pathological. A relationship is formed both at
Keum Hwa Lee, Jae Won Yang, Jin Young Cho, Joo Yup Lee, Eun Kyung Lim, Michael Eisenhut, Dong Yeon Jeong, Johanna Steingroever, Jae Il Shin   +8 more
doaj   +5 more sources

A new itch to scratch for TSLP [PDF]

Trends in Immunology, 2014
Atopic dermatitis (AD) is characterized by allergic inflammation and itch. Thymic stromal lymphopoietin (TSLP) is a pro-allergic cytokine implicated in AD. A paper in Cell transforms the understanding of the functional repertoire of TSLP in general and in AD in particular showing that TSLP can directly stimulate sensory neurons and provoke itch.
Turner, Matthew J., Zhou, Baohua
openaire   +3 more sources

MERS-CoV Infection and Its Impact on the Expression of TSLP Cytokine and IgG Antibodies: An In Vivo and In Vitro Study [PDF]

Infection and Drug Resistance
Ayman Mubarak,1 Mahfoudh Alqoufail,1 Saeedah Almutairi,1 Bahauddeen Alrfaei,2 Abdulaziz Almotairi,3 Ibrahim Aziz,1 Taghreed N Almanaa,1 Mostafa A Abdel-Maksoud,1 Mohamed A Farrag,1 Allolo D Aldreiwish,4 Maaweya E Awadalla,5 Bandar Alosaimi,5 Wael ...
Mubarak A, Alqoufail M, Almutairi S, Alrfaei B, Almotairi A, Aziz I, Almanaa TN, Abdel-Maksoud MA, Farrag MA, Aldreiwish AD, Awadalla ME, Alosaimi B, Alturaiki W   +12 more
doaj   +1 more source

Severe Asthmatic Responses: The Impact of TSLP

International Journal of Molecular Sciences, 2023
Asthma is a chronic inflammatory disease that affects the lower respiratory system and includes several categories of patients with varying features or phenotypes. Patients with severe asthma (SA) represent a group of asthmatics that are poorly responsive to medium-to-high doses of inhaled corticosteroids and additional controllers, thus leading in ...
Theofani, Efthymia, Tsitsopoulou, Aikaterini, Morianos, Ioannis, Semitekolou, Maria   +3 more
openaire   +3 more sources

TSLP is involved in expansion of early thymocyte progenitors [PDF]

BMC Immunology, 2007
Background Thymic stromal derived lymphopoietin (TSLP) is preferentially and highly expressed in the thymus, but its function in T cell development is not clear.
Coffield V McNeil, Jiang Qi, Kondo Motonari, Su Lishan   +3 more
doaj   +3 more sources

TSLP Expression: Cellular Sources, Triggers, and Regulatory Mechanisms [PDF]

Allergology International, 2012
Thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine initially identified in the culture supernatant of a thymic stromal cell line. Highly expressed in the epidermis in skin lesions of atopic dermatitis patients, TSLP was subsequently found to be
Toshiro Takai
doaj   +2 more sources

TSLP and TSLP receptors variants are associated with smoking [PDF]

Molecular Genetics & Genomic Medicine, 2019
AbstractBackgroundTo search for new prevention markers for early detection of the diseases caused by tobacco, we aimed to investigate the polymorphisms in TSLP and TSLPRs associated with cigarette smoking in the Saudi population.Materials and methodsSamples were collected from 177 smokers and 126 healthy controls. Three TSLP SNPs [rs3806933, rs2289276,
Abdelhabib Semlali, Mikhlid Almutairi, Arezki Azzi, Narasimha Reddy Parine, Abdullah AlAmri, Saleh Alsulami, Talal Meshal Alumri, Mohammad Saud Alanazi, Mahmoud Rouabhia   +8 more
openaire   +3 more sources

TSLP Expression: Analysis with a ZsGreen TSLP Reporter Mouse [PDF]

The Journal of Immunology, 2015
Abstract Thymic stromal lymphopoietin (TSLP) is a type I cytokine that plays a central role in induction of allergic inflammatory responses. Its principal targets have been reported to be dendritic cells and/or CD4 T cells; epithelial cells are a principal source.
Cedric, Dewas, Xi, Chen, Tetsuya, Honda, Ilkka, Junttila, Jay, Linton, Mark C, Udey, Stephen F, Porcella, Daniel E, Sturdevant, Lionel, Feigenbaum, Lily, Koo, Joy, Williams, William E, Paul   +11 more
openaire   +2 more sources