Results 11 to 20 of about 13,218 (205)

TSLP: contrasting roles in cancer

Frontiers in Immunology
Thymic stromal lymphopoietin (TSLP) is an alarmin cytokine possessing a plethora of pleiotropic properties. Human and mouse TSLP exerts their activity via a heterodimeric complex composed of TSLP receptor (TSLPR) chain and IL-7Rα.
Remo Poto, Remo Poto, Remo Poto, Gianni Marone, Gianni Marone, Gianni Marone, Steven F. Ziegler, Steven F. Ziegler, Steven F. Ziegler, Gilda Varricchi, Gilda Varricchi, Gilda Varricchi   +11 more
doaj   +4 more sources

TSLP and TSLP receptors variants are associated with smoking [PDF]

Molecular Genetics & Genomic Medicine, 2019
AbstractBackgroundTo search for new prevention markers for early detection of the diseases caused by tobacco, we aimed to investigate the polymorphisms in TSLP and TSLPRs associated with cigarette smoking in the Saudi population.Materials and methodsSamples were collected from 177 smokers and 126 healthy controls. Three TSLP SNPs [rs3806933, rs2289276,
Abdelhabib Semlali, Mikhlid Almutairi, Arezki Azzi, Narasimha Reddy Parine, Abdullah AlAmri, Saleh Alsulami, Talal Meshal Alumri, Mohammad Saud Alanazi, Mahmoud Rouabhia   +8 more
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TSLP Expression: Analysis with a ZsGreen TSLP Reporter Mouse [PDF]

The Journal of Immunology, 2015
Abstract Thymic stromal lymphopoietin (TSLP) is a type I cytokine that plays a central role in induction of allergic inflammatory responses. Its principal targets have been reported to be dendritic cells and/or CD4 T cells; epithelial cells are a principal source.
Cedric, Dewas, Xi, Chen, Tetsuya, Honda, Ilkka, Junttila, Jay, Linton, Mark C, Udey, Stephen F, Porcella, Daniel E, Sturdevant, Lionel, Feigenbaum, Lily, Koo, Joy, Williams, William E, Paul   +11 more
openaire   +2 more sources

TSLP signaling pathway map: a platform for analysis of TSLP-mediated signaling [PDF]

Database, 2014
Thymic stromal lymphopoietin (TSLP) is a four-helix bundle cytokine that plays a critical role in the regulation of immune responses and in the differentiation of hematopoietic cells. TSLP signals through a heterodimeric receptor complex consisting of an interleukin-7 receptor α chain and a unique TSLP receptor (TSLPR) [also known as cytokine receptor ...
Jun Zhong, Jyoti Sharma, Rajesh Raju, Shyam Mohan Palapetta, T. S. Keshava Prasad, Tai-Chung Huang, Akinori Yoda, Jeffrey W. Tyner, Diederik van Bodegom, David M. Weinstock, Steven F. Ziegler, Akhilesh Pandey   +11 more
openaire   +4 more sources

The influence of TSLP on the allergic response [PDF]

Mucosal Immunology, 2010
Exposure to allergens first occurs at body surfaces in direct contact with the environment such as the skin, airways, and gastrointestinal tract, and compelling evidence suggests that allergic inflammatory responses are profoundly influenced by the products of epithelial cells located at these sites.
M R, Comeau, S F, Ziegler
openaire   +2 more sources

Expression and Polymorphism of TSLP/TSLP Receptors as Potential Diagnostic Markers of Colorectal Cancer Progression [PDF]

Genes, 2021
Colorectal cancer (CRC) is the third most common malignancy and the fourth leading cause of cancer-related mortality worldwide. Inflammation is considered as a critical driver for CRC development and growth. We investigated the association between polymorphisms/expression levels of thymic stromal lymphopoietin (TSLP) /TSLP receptors and CRC risk in ...
Abdelhabib Semlali, Mikhlid H. Almutairi, Abdullah Alamri, Narasimha Reddy Parine, Maha Arafah, Majid A. Almadi, Abdulrahman M. Aljebreen, Othman Alharbi, Nahla Ali Azzam, Riyadh Almutairi, Mohammad Alanazi, Mahmoud Rouabhia   +11 more
openaire   +2 more sources

Interactions of thymic stromal lymphopoietin with interleukin-4 in adaptive immunity during Aspergillus fumigatus keratitis [PDF]

International Journal of Ophthalmology, 2021
AIM: To investigate the potential interactions of thymic stromal lymphopoietin (TSLP) with interleukin-4 (IL-4) in adaptive immunity during fungal keratitis (FK).
Chen Chen, Chen-Yang Dai, Fang Han, Jia-Yin Wu, Lin Sun, Xin-Yi Wu   +5 more
doaj   +1 more source

STIM/Orai-mediated calcium entry elicits spontaneous TSLP overproduction in epidermal cells of atopic dermatitis mice

Exploration of Immunology, 2023
Aim: Atopic dermatitis (AD) is a pruritic, chronic inflammatory skin disease. Thymic stromal lymphopoietin (TSLP) is highly expressed in the epidermis of patients with AD and induces T helper 2 (Th2) immune responses and itching.
Masanori Fujii, Shuhei Kobayashi, Ayane Ueda, Misaki Sakagami, Rieko Matsui, Yumeka Yamada, Takeshi Nabe, Susumu Ohya   +7 more
doaj   +1 more source

Human TSLP-Educated DCs [PDF]

Cellular & Molecular Immunology, 2008
Thymic stromal lymphopoietin (TSLP), an IL-7-related cytokine, is widely expressed by epithelial cells in many tissues with different biological effects. Human TSLP (hTSLP) has been shown to play an important role in promoting T cell homeostasis, developing nondeletional central tolerance, amplifying epithelium-induced class switching, inducing atopic ...
Jiongkun, Wang, Feiyue, Xing
openaire   +2 more sources

Thymic Stromal Lymphopoietin Is Implicated in the Pathogenesis of Bullous Pemphigoid by Dendritic Cells

Journal of Immunology Research, 2020
Objectives. Both thymic stromal lymphopoietin (TSLP) and dendritic cells (DCs) are involved in many autoimmune diseases, but the potential roles of TSLP and DCs in bullous pemphigoid (BP) have not been clarified. We sought to explore the contributions of
Si-Zhe Li, Xin-Xing Jin, Xiao-Lei Ge, Ya-Gang Zuo, Hong-Zhong Jin   +4 more
doaj   +1 more source