Results 31 to 40 of about 17,739 (188)

TSLP bronchoalveolar lavage levels at baseline are linked to clinical disease severity and reduced lung function in children with asthma

Frontiers in Pediatrics, 2022
RationaleThymic stromal lymphopoietin (TSLP) is increasingly recognized as a key molecule in asthma pathogenesis and as a promising therapeutic target in adults.
Elizabeth Chorvinsky, Gustavo Nino, Kyle Salka, Susana Gaviria, Maria J. Gutierrez, Dinesh K. Pillai   +5 more
doaj   +1 more source

A Comparative Study on Serum Levels of “Thymic Stromal Lymphopoietin” Between Patients with Psoriasis Vulgaris and Healthy Individuals: A Case-Control Study

Indian Dermatology Online Journal
Background: Thymic stromal lymphopoietin (TSLP) is a cytokine initially implicated to be associated with allergic disorders inducing Th2 response. Emerging studies have shown that TSLP is also involved in autoimmune diseases.
Siri Sri Kollabathula, Konakanchi Venkatachalam, Kethireddi Susmitha Divya, Patnala Guruprasad, Pallapati Anila Sunandini Nayar   +4 more
doaj   +1 more source

TSLP regulates mitochondrial ROS-induced mitophagy via histone modification in human monocytes

Cell & Bioscience, 2022
Background Thymic stromal lymphopoietin (TSLP) is a Th2-like cytokine involved in asthma pathogenesis. Excessive reactive oxygen species (ROS) production can lead to airway inflammation, hyperresponsiveness and remodeling.
Yi-Ching Lin, Yu-Chih Lin, Mei-Lan Tsai, Wei-Ting Liao, Chih-Hsing Hung   +4 more
doaj   +1 more source

Thymic stromal lymphopoietin (TSLP) and Toluene-diisocyanate-induced airway inflammation: alleviation by TSLP neutralizing antibody

, 2019
Toluene-diisocyanate (TDI) is mainly used in the manufacturing process of polyurethane foams, and is a potent inducer of occupational asthma characterized by airway inflammation and airway hyperreactivity.
Shao, Hua, Bo, Cunxiang, Zhang, Yu, Lavin, Martin F., Peng, Cheng, Yu, Gongchang, Wang, Xiaoqun, Sai, Linlin, Yeo, Abrey J., Jia, Qiang   +9 more
core   +1 more source

Synthetic small interfering RNAs selectively suppress the expression of proinflammatory cytokine genes (IL-25 and TSLP) in experiments in vitro

Медицинская иммунология
Allergic rhinitis (AR) is an inflammatory disease of the upper respiratory tract (nasal mucosa). AR affects up to 40% of the world’s population; in the Russian Federation, the incidence is 18% to 30%, depending on the region.
M. M. Kaganova, I. P. Shilovskiy, E. D. Timotievich, K. V. Yumashev, D. A. Gurskii, K. V. Vinogradova, M. V. Popova, M. R. Khaitov   +7 more
doaj   +1 more source

Thymic Stromal Lymphopoietin Promotes MRGPRX2-Triggered Degranulation of Skin Mast Cells in a STAT5-Dependent Manner with Further Support from JNK

Cells, 2021
Thymic stromal lymphopoietin (TSLP) is released by epithelial cells following disturbed homeostasis to act as “alarmin” and driver of Th2-immunity. Aberrant TSLP expression is a hallmark of atopic diseases, including atopic dermatitis (AD).
Magda Babina, Zhao Wang, Kristin Franke, Torsten Zuberbier   +3 more
doaj   +1 more source

Assessing the Mucosal Inflammatory Endotype of Obesity in Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory syndrome of the paranasal sinuses that is defined phenotypically as either with nasal polyps (CRSwNP) or without nasal polyps (CRSsNP). More recently, inflammatory markers have been used to cluster patients into putative endotypes that are presumed to have a common ...
Jeffanie W. Gayoso, Li‐Ching Huang, Quanhu Sheng, Daniel Lofgren, Ping Li, Katherine Cahill, Mason Krysinski, Rakesh K. Chandra, Justin H. Turner, Naweed Chowdhury   +9 more
wiley   +1 more source

No evidence for TSLP pathway activity in human breast cancer

, 2016
Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine that primes dendritic cells for Th2 induction. It has been implicated in different types of allergic diseases.
Ghirelli, Cristina, Scholer-Dahirel, Alix, Zollinger, Raphael, Sirven, Philemon, Martinez-Cingolani, Carolina, Michea, Paula, Soumelis, Vassili, Guillot-Delost, Maude, Reyal, Fabien, Nicolas, Andre, Sadacca, Benjamin, Pattarini, Lucia   +11 more
core   +1 more source

TSLP Inhibitors for Asthma: Current Status and Future Prospects

, 2020
Thymic stromal lymphopoietin (TSLP) is an allarmin cytokine whose importance in human asthma has been repeatedly documented. Accordingly, targeting of TSLP and TSLP-mediated signalling is considered as an attractive therapeutic strategy to asthma ...
Matera M. G., Calzetta L., Rogliani P., Cazzola M.   +3 more
core   +1 more source

Thymic stromal lymphopoietin promotes abdominal aortic aneurysm formation by regulating macrophage polarization

Frontiers in Immunology
BackgroundThe inflammatory cytokine thymic stromal lymphopoietin (TSLP) has pleiotropic roles in immune response and tissue homeostasis, yet its function in abdominal aortic aneurysm (AAA) remains entirely unexplored.MethodsWe integrated clinical ...
Qi Zheng, Qi Zheng, Qi Zheng, Xuhong Wang, Xuhong Wang, Xuhong Wang, Xinglin Chen, Xinglin Chen, Xinglin Chen, Mingkai Huang, Mingkai Huang, Mingkai Huang, Xuzhe Zhang, Xuzhe Zhang, Xuzhe Zhang, Qinlin Li, Qinlin Li, Qinlin Li, Zhengjie Huang, Zhengjie Huang, Zhengjie Huang, Mingyi Li, Mingyi Li, Mingyi Li, Jingyong Li, Jingyong Li, Jingyong Li, Wangling Hu, Wangling Hu, Wangling Hu, Ni Xia, Ni Xia, Ni Xia, Lingfeng Zha, Lingfeng Zha, Lingfeng Zha, Jiao Jiao, Jiao Jiao, Jiao Jiao, Fen Yang, Fen Yang, Fen Yang, Tingting Tang, Tingting Tang, Tingting Tang, Xiang Cheng, Xiang Cheng, Xiang Cheng   +47 more
doaj   +1 more source