Results 31 to 40 of about 16,704 (236)

Thymic Stromal Lymphopoietin Isoforms, Inflammatory Disorders, and Cancer

Frontiers in Immunology, 2018
Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine originally isolated from a murine thymic stromal cell line. TSLP exerts its biological effects by binding to a high-affinity heteromeric complex composed of thymic stromal lymphopoietin ...
Gilda Varricchi, Gilda Varricchi, Antonio Pecoraro, Antonio Pecoraro, Giancarlo Marone, Giancarlo Marone, Gjada Criscuolo, Gjada Criscuolo, Giuseppe Spadaro, Giuseppe Spadaro, Arturo Genovese, Arturo Genovese, Gianni Marone, Gianni Marone, Gianni Marone   +14 more
doaj   +1 more source

TSLP is associated with asthma

, 2021
Background Single nucleotide polymorphisms (SNPs) in thymic stromal lymphopoietin (TSLP) have been associated with IgE (in girls) and asthma (in general).
Mathias, Rasika A., Choi, Augustine M.K., Wilk, Jemma B., Ruczinski, Ingo, Bush, Andrew, Soto-Quirós, Manuel E., Lasky‐Su, Jessica A., Hunninghake, Gary, Klanderman, Barbara, Liang, Catherine, Celedón, Juan C., Gauderman, W. James, Raby, Benjamin, Weiss, Scott, Baurley, James W., Sylvia, Jody, Vora, Hita, O’Connor, George T., Himes, Blanca E., Sharma, Sunita, Israel, Elliot, Beaty, Terry H., Bossley, Cara J., Avila, Lydiana, Kim, Hong P., Rafaels, Nicholas, Barnes, Kathleen C., Gilliland, Frank   +27 more
core   +1 more source

ΔNp63 controls a TLR3-mediated mechanism that abundantly provides thymic stromal lymphopoietin in atopic dermatitis.

PLoS ONE, 2014
In the skin lesions of atopic dermatitis (AD), keratinocytes release large quantities of thymic stromal lymphopoietin (TSLP), causing unfavorable inflammation along with skin damage.
Terufumi Kubo, Ryuta Kamekura, Ayako Kumagai, Koji Kawata, Keiji Yamashita, Yukari Mitsuhashi, Takashi Kojima, Kotaro Sugimoto, Akihiro Yoneta, Yasuyuki Sumikawa, Toshiharu Yamashita, Noriyuki Sato, Tetsuo Himi, Shingo Ichimiya   +13 more
doaj   +1 more source

Inflammatory Cytokine TSLP Stimulates Platelet Secretion and Potentiates Platelet Aggregation via a TSLPR-Dependent PI3K/Akt Signaling Pathway

Cellular Physiology and Biochemistry, 2015
Aims: Thymic stromal lymphopoietin (TSLP) plays an important role in inflammatory diseases and is over-expressed in human atherosclerotic artery specimens.
Jangchuan Dong, Jing Lin, Boyuan Wang, Shaolin He, Chun Wu, Kishan Kumar Kushwaha, Nilesh Mohabeer, Yousu Su, Hongcheng Fang, Kai Huang, Dazhu Li   +10 more
doaj   +1 more source

Role of the TSLP and its Receptor in the Treatment of Asthma

Barcelona Respiratory Network Reviews, 2023
Thymic stromal lymphopoietin (TSLP) is a crucial cytokine in initiating and regulating immune responses. Various cell types, including epithelial cells, fibroblasts, and dendritic cells, synthesize TSLP. TSLP activates dendritic cells, which subsequently
Miguel Estravís, Ignacio Dávila, Asunción García-Sánchez   +2 more
doaj   +1 more source

Skin tissue expression and serum level of thymic stromal lymphopoietin in patients with psoriasis vulgaris

Dermatology Reports, 2019
Thymic stromal lymphopoietin (TSLP) is known to be associated with allergic diseases. It is also suggested that TSLP has a role in autoimmune diseases such as psoriasis; however, the associated pathways remain unknown.
Oki Suwarsa, Hartati Purbo Dharmadji, Endang Sutedja, Lengga Herlina, Putri Reno Sori, Reti Hindritiani, Reiva Farah Dwiyana, Hendra Gunawan   +7 more
doaj   +1 more source

Expression of Thymic Stromal Lymphopoietin in Immune-Related Dermatoses

Mediators of Inflammation, 2022
Thymic stromal lymphopoietin (TSLP), long known to be involved in Th2 response, is also implicated in multiple inflammatory dermatoses and cancers. The purpose of this study was to improve our understanding of the expression of TSLP in the skin of those ...
Si-Zhe Li, Xin-Xing Jin, Yin Shan, Hong-Zhong Jin, Ya-Gang Zuo   +4 more
doaj   +1 more source

Thymic Stromal Lymphopoietin Promotes MRGPRX2-Triggered Degranulation of Skin Mast Cells in a STAT5-Dependent Manner with Further Support from JNK

Cells, 2021
Thymic stromal lymphopoietin (TSLP) is released by epithelial cells following disturbed homeostasis to act as “alarmin” and driver of Th2-immunity. Aberrant TSLP expression is a hallmark of atopic diseases, including atopic dermatitis (AD).
Magda Babina, Zhao Wang, Kristin Franke, Torsten Zuberbier   +3 more
doaj   +1 more source

A Comparative Study on Serum Levels of “Thymic Stromal Lymphopoietin” Between Patients with Psoriasis Vulgaris and Healthy Individuals: A Case-Control Study

Indian Dermatology Online Journal
Background: Thymic stromal lymphopoietin (TSLP) is a cytokine initially implicated to be associated with allergic disorders inducing Th2 response. Emerging studies have shown that TSLP is also involved in autoimmune diseases.
Siri Sri Kollabathula, Konakanchi Venkatachalam, Kethireddi Susmitha Divya, Patnala Guruprasad, Pallapati Anila Sunandini Nayar   +4 more
doaj   +1 more source

TSLP regulates mitochondrial ROS-induced mitophagy via histone modification in human monocytes

Cell & Bioscience, 2022
Background Thymic stromal lymphopoietin (TSLP) is a Th2-like cytokine involved in asthma pathogenesis. Excessive reactive oxygen species (ROS) production can lead to airway inflammation, hyperresponsiveness and remodeling.
Yi-Ching Lin, Yu-Chih Lin, Mei-Lan Tsai, Wei-Ting Liao, Chih-Hsing Hung   +4 more
doaj   +1 more source