Results 11 to 20 of about 63,242,370 (271)

Role of IL-25 in Immunity [PDF]

Journal of Clinical and Diagnostic Research, 2015
IL-25 a 2o KDa protein mostly known as IL-17E, encoded by chromosome 14, and containing 117 amino acids. Cytokine IL-17 family consists of 6 members; IL-17A to IL-17F, among which IL-25 has a unique structure and function. The receptor of IL-25 (IL-17BR)
Azar Valizadeh, Afra Khosravi, Layla Jafar Zadeh, Elaheh Gholami Parizad   +3 more
doaj   +4 more sources

IL-25 and IL-25 receptor expression on eosinophils from subjects with allergic asthma.

International Archives of Allergy and Immunology, 2014
BACKGROUND: Allergic asthma is an inflammatory airway disease in which Th2 cytokines play an important role. Epithelial-derived interleukin (IL)-25 has been suggested to be important in the maintenance of Th2-type responses.
Howie, Karen, Tang, Wei, O'Byrne, Paul M, Smith, Steven G, Beaudin, Sue, Dua, Benny, Gauvreau, Gail   +6 more
core   +4 more sources

Serum concentrations of 25-OH vitamin D and the pro-inflammatory interleukins IL-17, IL-23, and IL-18 in patients with plaque psoriasis

Biomedical Papers
Aims. The present study aimed to assess vitamin D status and serum concentrations of pro-inflammatory cytokines IL-17, Il-23, and IL-18 in patients with chronic plaque psoriasis and their association with various demographic and clinical characteristics.
Maria Ganeva, Zhivka Tsokeva, Tanya Gancheva, Evgeniya Hristakieva, Vanya Tsoneva, Irena Manolova   +5 more
doaj   +2 more sources

IL-25 (IL-17E) in epithelial immunology and pathophysiology

Journal of Allergy and Clinical Immunology, 2021
IL-25, also known as IL-17E, is a unique cytokine of the IL-17 family. Indeed, IL-25 exclusively was shown to strongly induce expression of the cytokines associated with type 2 immunity. Although produced by several types of immune cells, such as T cells,
Boehncke, Wolf-Henning, Brembilla, Nicolo, Julia Borowczyk, Nicolo Costantino Brembilla, Maria Shutova, Wolf-Henning Boehncke, Borowczyk, Julia, Shutova, Maria   +7 more
core   +4 more sources

IL-25 promotes trophoblast proliferation and invasion via binding with IL-17RB and associated with PE

Hypertension in Pregnancy, 2021
Introduction: Interleukin-25 is a Th2 interleukin and has been shown to influence cell behavior. This study aims to illustrate its affection on extravillous trophoblasts function and association with PE.
Siyu Liu, Yi Sun, Yao Tang, Rong Hu, Qiongjie Zhou, Xiaotian Li   +5 more
doaj   +2 more sources

IL-25 blockade inhibits metastasis in breast cancer [PDF]

Protein & Cell, 2016
Metastasis is the leading cause of death in breast cancer patients. However, the mechanisms underlying metastasis are not well understood and there is no effective treatment in the clinic.
Zhujun Jiang, Jingtao Chen, Xuemei Du, Hang Cheng, Xiaohu Wang, Chen Dong   +5 more
doaj   +3 more sources

IL-25 blockade augments antiviral immunity during respiratory virus infection. [PDF]

Commun Biol, 2022
IL-25 is implicated in the pathogenesis of viral asthma exacerbations. However, the effect of IL-25 on antiviral immunity has yet to be elucidated. We observed abundant expression and colocalization of IL-25 and IL-25 receptor at the apical surface of ...
Williams TC, Loo SL, Nichol KS, Reid AT, Veerati PC, Esneau C, Wark PAB, Grainge CL, Knight DA, Vincent T, Jackson CL, Alton K, Shimkets RA, Girkin JL, Bartlett NW.   +14 more
europepmc   +2 more sources

Interleukin 25 (IL-25) expression in cholangiocarcinoma. [PDF]

Mol Clin Oncol, 2020
Various cytokines are involved in carcinogenesis and tumor progression. Some tumor cells produce cytokines by themselves. Using secretome analysis, a high expression of APEX-1 was found in cholangiocarcinoma (CCA) cell lines. During this secretome analysis, it was found that CCA cell lines overexpressed some cytokines and related molecules, including ...
Kaewsarabhumi S, Proungvitaya T, Limpaiboon T, Tippayawat P, Tummanatsakun D, Titapun A, Sa-Ngaimwibool P, Proungvitaya S.   +7 more
europepmc   +4 more sources

Differential Effects of Alarmins on Human and Mouse Basophils

Frontiers in Immunology, 2022
Epithelial-derived alarmins (IL-33, TSLP, and IL-25) play an upstream role in the pathogenesis of asthma. Basophil-derived cytokines are a pivotal component of allergic inflammation.
Adriana R. Gambardella, Adriana R. Gambardella, Remo Poto, Remo Poto, Remo Poto, Remo Poto, Valentina Tirelli, John T. Schroeder, Gianni Marone, Gianni Marone, Gianni Marone, Gianni Marone, Fabrizio Mattei, Gilda Varricchi, Gilda Varricchi, Gilda Varricchi, Gilda Varricchi, Giovanna Schiavoni   +17 more
doaj   +1 more source

IL-25 Enhances B Cell Responses in Type 2 Inflammation Through IL-17RB Receptor. [PDF]

Allergy
Background: Alarmin cytokine IL-25 promotes type 2 inflammatory responses in disorders such as asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) and known targets include ILC2 and Th2 cells.
Abdu S, Xia J, Yuan H, Tan TJ, Layhadi JA, Shamji MH, McKenzie ANJ, Haloob N, Hopkins C, Woszczek G, Till SJ.   +10 more
europepmc   +2 more sources