Results 31 to 40 of about 7,371,445 (279)

Regulation of IL-9 expression by IL-25 signaling [PDF]

Nature Immunology, 2010
The physiological regulation of the expression of interleukin (IL)-9, a cytokine traditionally regarded as being T(H)2 associated, remains unclear. Here, we show that IL-9-expressing T cells generated in vitro in the presence of transforming growth factor-beta and IL-4 express high levels of mRNA for IL-17 receptor B (IL-17RB), the receptor for IL-25 ...
Angkasekwinai, Pornpimon, Chang, Seon Hee, Thapa, Manoj, Watarai, Hiroshi, Dong, Chen   +4 more
openaire   +2 more sources

Cytoplasmic tail of IL-13Ralpha2 regulates IL-4 signal transduction [PDF]

, 2009
IL (interleukin)-4 and IL-13 are key cytokines in the pathogenesis of allergic inflammatory disease. IL-4 and IL-13 share many functional properties as a result of their utilization of a common receptor complex comprising IL-13Ralpha1 (IL-13 receptor ...
Donna E. Davies, Holgate, Stephen T, Isabelle Kirby, Ida Karin Nordgren, Tavassoli, Ali, Davies, Donna E, Holloway, John W, Andrews, Allison-Lynn, Stephen T. Holgate, Nordgren, Ida Karin, John W. Holloway, Kirby, Isabelle, Allison-Lynn Andrews, Ali Tavassoli   +13 more
core   +1 more source

The IL-17 Family of Cytokines in Psoriasis: IL-17A and Beyond

Frontiers in Immunology, 2018
Psoriasis is a frequent chronic inflammatory skin disease, nowadays considered a major global health problem. Several new drugs, targeting the IL-23/IL-17A pathway, have been recently licensed or are in clinical development.
Nicolo Costantino Brembilla, Luisa Senra, Wolf-Henning Boehncke, Wolf-Henning Boehncke   +3 more
doaj   +1 more source

Biological Properties and the Role of IL-25 in Disease Pathogenesis [PDF]

Journal of Immunology Research, 2018
The interleukin- (IL-) 17 superfamily, a T cell-derived cytokine, consists of 6 ligands (IL-17A–IL-17F) and 5 receptors (IL-17RA–IL-17RE). IL-17A, a prototype member of this family, is involved in the pathogenesis of allergies, autoimmune diseases, allograft transplantations, and malignancies.
Yuwan Liu, Zewei Shao, Guoqiang Shangguan, Qingli Bie, Bin Zhang   +4 more
openaire   +3 more sources

IL-25 regulates Th17 function in autoimmune inflammation [PDF]

The Journal of Experimental Medicine, 2007
Interleukin (IL)-25 is a member of the IL-17 family of cytokines. However, unlike the other members of this family, IL-25 promotes T helper (Th) 2 responses. We now show that IL-25 also regulates the development of autoimmune inflammation mediated by IL-17–producing T cells.
Kleinschek, Melanie A., Owyang, Alexander M., Joyce-Shaikh, Barbara, Langrish, Claire L., Chen, Yi, Gorman, Daniel M., Blumenschein, Wendy M., McClanahan, Terrill, Brombacher, Frank, Hurst, Stephen D., Kastelein, Robert A., Cua, Daniel J.   +11 more
openaire   +2 more sources

Clonorchis sinensis lysophospholipase A upregulates IL-25 expression in macrophages as a potential pathway to liver fibrosis

Parasites & Vectors, 2017
Background Liver fibrosis is an excessive wound-healing reaction that requires the participation of inflammatory cells and hepatic stellate cells (HSCs).
Lina Zhou, Mengchen Shi, Lu Zhao, Zhipeng Lin, Zeli Tang, Hengchang Sun, Tingjin Chen, Zhiyue Lv, Jin Xu, Yan Huang, Xinbing Yu   +10 more
doaj   +1 more source

Determination of the functional biology of IL‐25

The FASEB Journal, 2008
Interleukin (IL)‐25 (IL‐17E) is a recently described member of the IL‐17 cytokine family. Recent studies have demonstrated key functions of IL‐25 in T H 2 cytokine‐mediated host protective immunity and in the inhibition of IL‐17‐mediated inflammation.
Steven A. Saenz, Colby Zaph, Daniel J. Cua, Robert A. Kastelein, David Artis   +4 more
openaire   +1 more source

Street and Urban Muralism in Public Art: Conservation Between Evolution and Research in the Methods of the Istituto Centrale per Il Restauro

Heritage
This paper presents an overview of a research line developed at the Istituto Centrale per il Restauro within the CHANGES (Cultural Heritage Active Innovation for Next-Gen Sustainable Society) project, funded under the Italian National Recovery and ...
Paola Mezzadri, Sara De Angelis, Rebecca Picca Orlandi, Michela Renna, Giancarlo Sidoti   +4 more
doaj   +1 more source

Alarmin Cytokines as Central Regulators of Cutaneous Immunity

Frontiers in Immunology, 2022
Skin acts as the primary interface between the body and the environment. The skin immune system is composed of a complex network of immune cells and factors that provide the first line of defense against microbial pathogens and environmental insults ...
Tatsuya Hasegawa, Tomonori Oka, Shadmehr Demehri   +2 more
doaj   +1 more source

New insights into the function of Interleukin-25 in disease pathogenesis

Biomarker Research, 2023
Interleukin-25 (IL-25), also known as IL-17E, is a cytokine belonging to the IL-17 family. IL-25 is abundantly expressed by Th2 cells and various kinds of epithelial cells.
Qingfang Yuan, Na Peng, Fan Xiao, Xiaofei Shi, Bo Zhu, Ke Rui, Jie Tian, Liwei Lu   +7 more
doaj   +1 more source