Results 41 to 50 of about 63,242,370 (271)

Revisiting the interleukin 17 family of cytokines in psoriasis: pathogenesis and potential targets for innovative therapies

Frontiers in Immunology, 2023
Psoriasis is a common chronic inflammatory skin disease, associated with substantial comorbidity. TH17 lymphocytes, differentiating under the influence of dendritic cell-derived IL-23, and mediating their effects via IL-17A, are believed to be central ...
Nicolo Costantino Brembilla, Wolf-Henning Boehncke, Wolf-Henning Boehncke   +2 more
doaj   +1 more source

Breast cancer therapy with IL-25 [PDF]

Science-Business eXchange, 2011
A U.S.-Taiwan team has shown that the proinflammatory cytokine IL-25 exerts potent cytotoxic effects in breast cancer cells and decreases mammary tumor growth in mice. The researchers and an undisclosed company will collaborate to develop systems for delivering IL-25 or its mimetics directly to tumors.
openaire   +1 more source

Regulation of IL-9 expression by IL-25 signaling [PDF]

Nature Immunology, 2010
The physiological regulation of the expression of interleukin (IL)-9, a cytokine traditionally regarded as being T(H)2 associated, remains unclear. Here, we show that IL-9-expressing T cells generated in vitro in the presence of transforming growth factor-beta and IL-4 express high levels of mRNA for IL-17 receptor B (IL-17RB), the receptor for IL-25 ...
Angkasekwinai, Pornpimon, Chang, Seon Hee, Thapa, Manoj, Watarai, Hiroshi, Dong, Chen   +4 more
openaire   +2 more sources

Bridging the Loneliness Gap: Depression, Connectivity, and Isolation in Pediatric Oncology Patients and Their Peers

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Loneliness is associated with adverse physical and mental health outcomes and remains understudied in children and adolescents undergoing cancer therapy. Pediatric oncology patients may be at increased risk due to medical isolation and disruption of social networks.
Charlotte N. Stahlfeld, Scott H. Maurer, Michelle D. Watkinson, John Nury, Elise Barberis, Molly C. Mack   +5 more
wiley   +1 more source

Biological Properties and the Role of IL-25 in Disease Pathogenesis [PDF]

Journal of Immunology Research, 2018
The interleukin- (IL-) 17 superfamily, a T cell-derived cytokine, consists of 6 ligands (IL-17A–IL-17F) and 5 receptors (IL-17RA–IL-17RE). IL-17A, a prototype member of this family, is involved in the pathogenesis of allergies, autoimmune diseases, allograft transplantations, and malignancies.
Yuwan Liu, Zewei Shao, Guoqiang Shangguan, Qingli Bie, Bin Zhang   +4 more
openaire   +3 more sources

PVA–Borax Double-Network Gels for Sustainable and Selective Cleaning of Highly Textured Street and Urban Murals

Heritage
The removal of spray paint vandalism from contemporary mural paintings and Street and Urban Art represents one of the most challenging operations in conservation practice, particularly when the unwanted layers are chemically similar to the original ...
Michela Renna, Sara De Angelis, Giancarlo Sidoti, Paola Mezzadri   +3 more
doaj   +1 more source

Early Body Mass Index z‐Score Change and Resolution of Severe Malnutrition in Children With Sickle Cell Anemia in a Low‐Income Setting: A Prospective Single‐Arm Extension Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell anemia (SCA) in low‐income settings are at risk of severe malnutrition, but optimal nutritional management has not been established. We evaluated an intensified ready‐to‐use therapeutic food (RUTF) regimen in children with persistent severe malnutrition after initial treatment and assessed whether early ...
Safiya Gambo, Shehu Umar Abdullahi, Hassan Adam Murtala, Halima Kabir, Khadija A. Shamsu, Sari A. Acra, Virginia A. Stallings, Mark Rodeghier, Michael R. DeBaun, Lauren J. Klein   +9 more
wiley   +1 more source

IL-25 regulates Th17 function in autoimmune inflammation [PDF]

The Journal of Experimental Medicine, 2007
Interleukin (IL)-25 is a member of the IL-17 family of cytokines. However, unlike the other members of this family, IL-25 promotes T helper (Th) 2 responses. We now show that IL-25 also regulates the development of autoimmune inflammation mediated by IL-17–producing T cells.
Kleinschek, Melanie A., Owyang, Alexander M., Joyce-Shaikh, Barbara, Langrish, Claire L., Chen, Yi, Gorman, Daniel M., Blumenschein, Wendy M., McClanahan, Terrill, Brombacher, Frank, Hurst, Stephen D., Kastelein, Robert A., Cua, Daniel J.   +11 more
openaire   +2 more sources

The Role of Airway Epithelial Cell Alarmins in Asthma

Cells, 2022
The airway epithelium is the first line of defense for the lungs, detecting inhaled environmental threats through pattern recognition receptors expressed transmembrane or intracellularly.
Christiane E. Whetstone, Maral Ranjbar, Hafsa Omer, Ruth P. Cusack, Gail M. Gauvreau   +4 more
doaj   +1 more source

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source