Results 1 to 10 of about 8,634 (215)
Nuclear Alarmin Cytokines in Inflammation [PDF]
Journal of Immunology Research, 2020 Pathogen‐associated molecular patterns (PAMPs) are some nonspecific and highly conserved molecular structures of exogenous specific microbial pathogens, whose products can be recognized by pattern recognition receptor (PRR) on innate immune cells and induce an inflammatory response.
Lili Jiang +4 more
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Activation of innate immunity by 14-3-3 ε, a new potential alarmin in osteoarthritis
Osteoarthritis and Cartilage, 2020 International audienceObjective: The innate immune system plays a central role in osteoarthritis (OA). We identified 14-3-3ε as a novel mediator that guides chondrocytes toward an inflammatory phenotype.
L Sudre, Frédéric Pene
exaly +2 more sources
Medicina, 2022 Schizophrenia, consisting of a group of severe psychiatric disorders with a complex etiology, is a leading cause of disability globally. Due to the lack of objective indicators, accurate diagnosis and selection of effective treatments for schizophrenia remain challenging.
Huan Ma, Ning Cheng, Caiyi Zhang
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Sounding the alarmins—The role of alarmin cytokines in asthma
Allergy, 2022 AbstractThe alarmin cytokines thymic stromal lymphopoietin (TSLP), interleukin (IL)‐33, and IL‐25 are epithelial cell‐derived mediators that contribute to the pathobiology and pathophysiology of asthma. Released from airway epithelial cells exposed to environmental triggers, the alarmins drive airway inflammation through the release of predominantly T2
Gail M. Gauvreau +9 more
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Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis [PDF]
, 2021 Summary Functional contributions of individual cellular components of the bone-marrow microenvironment to myelofibrosis (MF) in patients with myeloproliferative neoplasms (MPNs) are incompletely understood. We aimed to generate a comprehensive map of the
Gütgemann, Ines +25 more
core +3 more sources
Immunological Reviews, 2017 SummaryMore than a decade has passed since the conceptualization of the “alarmin” hypothesis. The alarmin family has been expanding in terms of both number and the concept. It has recently become clear that alarmins play important roles as initiators and participants in a diverse range of physiological and pathophysiological processes such as host ...
De Yang, Zhen Han, Joost J. Oppenheim
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Alarmins, COVID-19 and comorbidities [PDF]
Annals of Medicine, 2021 The coronavirus SARS-CoV-2, the aetiological agent of COVID-19 disease, is representing a worldwide threat for the medical community and the society at large so that it is being defined as "the twenty-first-century disease". Often associated with a severe cytokine storm, leading to more severe cases, it is mandatory to block such occurrence early in ...
Di Salvo E. +4 more
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New Perspectives on Classical Alarmin Responses to Intestinal Helminth Infection [PDF]
Parasite ImmunologyRichard K Grencis, Connor P Lynch
exaly +2 more sources
Alarmins and Antitumor Immunity [PDF]
Clinical Therapeutics, 2016 Alarmins are constitutively present endogenous molecules that essentially act as early warning signals for the immune system. We provide a brief overview of major alarmins and highlight their roles in tumor immunity.We searched PubMed up to January 10, 2016, using alarmins and/or damage-associated molecular patterns (DAMPs), as key words.
Yingjie, Nie +2 more
openaire +2 more sources