Results 41 to 50 of about 7,888 (200)

Alarmins, inflammasomes and immunity

Biomedical Journal, 2012
The elaboration of an effective immune response against pathogenic microbes such as viruses, intracellular bacteria or protozoan parasites relies on the recognition of microbial products called pathogen-associated molecular patterns (PAMPs) by pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs).
Najwane Saïd-Sadier, David M Ojcius
openaire   +3 more sources

First-Breath-Induced Type 2 Pathways Shape the Lung Immune Environment

Cell Reports, 2017
From birth onward, the lungs are exposed to the external environment and therefore harbor a complex immunological milieu to protect this organ from damage and infection.
Simona Saluzzo, Anna-Dorothea Gorki, Batika M.J. Rana, Rui Martins, Seth Scanlon, Philipp Starkl, Karin Lakovits, Anastasiya Hladik, Ana Korosec, Omar Sharif, Joanna M. Warszawska, Helen Jolin, Ildiko Mesteri, Andrew N.J. McKenzie, Sylvia Knapp   +14 more
doaj   +1 more source

Macrophage Death following Influenza Vaccination Initiates the Inflammatory Response that Promotes Dendritic Cell Function in the Draining Lymph Node

Cell Reports, 2017
The mechanism by which inflammation influences the adaptive response to vaccines is not fully understood. Here, we examine the role of lymph node macrophages (LNMs) in the induction of the cytokine storm triggered by inactivated influenza virus vaccine ...
Nikolaos Chatziandreou, Yagmur Farsakoglu, Miguel Palomino-Segura, Rocco D’Antuono, Diego Ulisse Pizzagalli, Federica Sallusto, Veronika Lukacs-Kornek, Mariagrazia Uguccioni, Davide Corti, Shannon J. Turley, Antonio Lanzavecchia, Michael C. Carroll, Santiago F. Gonzalez   +12 more
doaj   +1 more source

Extracellular Nucleophosmin Is Increased in Psoriasis and Correlates With the Determinants of Cardiovascular Diseases

Frontiers in Cardiovascular Medicine, 2022
We previously showed that genotoxic stress induced an active extracellular release of nucleophosmin (NPM) in human cardiac mesenchymal progenitor cells, and that serum deprivation provokes NPM secretion from human endothelial cells, eliciting ...
Marco D'Agostino, Sara Beji, Sara Sileno, Daniela Lulli, Laura Mercurio, Stefania Madonna, Corrado Cirielli, Sabatino Pallotta, Cristina Albanesi, Maurizio C. Capogrossi, Maurizio C. Capogrossi, Daniele Avitabile, Guido Melillo, Alessandra Magenta   +13 more
doaj   +1 more source

Serum calprotectin in nonsegmental vitiligo: a possible marker of disease activity

Journal of the Egyptian Women’s Dermatologic Society
Background Determining the status of nonsegmental vitiligo is crucial in initiating the management plan, especially when planning for surgery. Serum biomarkers can serve as an additive tool, to clinical examination and history-taking, in differentiating ...
Dalia A. Bassiouny, Yasmin B. El Zawahry, Ahmed M. Soliman, Alaa H. Sayed, Eman R. Youness, Dina G. Saadi   +5 more
doaj   +1 more source

S100A1 is released from ischemic cardiomyocytes and signals myocardial damage via Toll‐like receptor 4

EMBO Molecular Medicine, 2014
Members of the S100 protein family have been reported to function as endogenous danger signals (alarmins) playing an active role in tissue inflammation and repair when released from necrotic cells.
David Rohde, Christoph Schön, Melanie Boerries, Ieva Didrihsone, Julia Ritterhoff, Katharina F Kubatzky, Mirko Völkers, Nicole Herzog, Mona Mähler, James N Tsoporis, Thomas G Parker, Björn Linke, Evangelos Giannitsis, Erhe Gao, Karsten Peppel, Hugo A Katus, Patrick Most   +16 more
doaj   +1 more source

Epicutaneous Immunity and Onset of Allergic Diseases - Per-“Eczema”tous Sensitization Drives the Allergy March

Allergology International, 2013
Results: from recent epidemiological studies strongly suggest that ingestion of food promotes immune tolerance to food antigens, whereas exposure to food antigens through skin leads to allergic sensitization.
Kenji Matsumoto, Hirohisa Saito
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Alarmins and Related Molecules in Elective Surgery

Folia Biologica, 2023
Surgery is associated with alterations of alarmins’ and related molecules’ levels. The aim of this study was to investigate which biomarkers are most involved in surgery. The studied group consisted of 58 patients with inguinal or umbilical hernia or cholecystolithiasis and 21 healthy controls for compa­rison.
Sabina, Strohalmová, Kateřina, Levová, Aleš Antonín, Kuběna, David, Hoskovec, Zdeněk, Krška, Tomáš, Zima, Marta, Kalousová   +6 more
openaire   +2 more sources

Role of alarmin cytokines and microRNAs in the host-schistosome interaction [version 1; referees: 3 approved]

F1000Research, 2018
Schistosomiasis is a serious but neglected tropical infectious disease, afflicting more than 240 million people in 78 countries. Lack of an effective vaccine and obscuring disease mechanism could be the main hurdles to effectively control and eradicate ...
Xing He, Weiqing Pan
doaj   +1 more source