Results 41 to 50 of about 8,634 (215)

USB1 deficiency disrupts neutrophil maturation via RNA dysregulation independent of global pre‐mRNA splicing

Animal Models and Experimental Medicine, EarlyView.
This graphical abstract illustrates the essential role of USB1 in neutrophil maturation. In normal myeloid cells, USB1 acts as an RNA exonuclease, trimming RNA tails to maintain proper RNA network function, which supports the differentiation of myeloid progenitor cells into mature neutrophils.
Hang Li, Guiying Shi, Jiaming Tang, Yiying Huang, Jie Wang, Xuepei Lei, Lin Bai   +6 more
wiley   +1 more source

Tumor necrosis factor is a necroptosis-associated alarmin [PDF]

, 2022
Necroptosis is a form of regulated cell death that can occur downstream of several immune pathways. While previous studies have shown that dysregulated necroptosis can lead to strong inflammatory responses, little is known about the identity of the ...
Gaidt, Moritz M., Pinci, Francesca, Jung, Christophe, Kuut, Gunnar, Hornung, Veit, Nagl, Dennis   +5 more
core   +1 more source

Alarmins link neutrophils and dendritic cells [PDF]

Trends in Immunology, 2009
Neutrophils are the first major population of leukocyte to infiltrate infected or injured tissues and are crucial for initiating host innate defense and adaptive immunity. Although the contribution of neutrophils to innate immune defense is mediated predominantly by phagocytosis and killing of microorganisms, neutrophils also participate in the ...
De, Yang, Gonzalo, de la Rosa, Poonam, Tewary, Joost J, Oppenheim   +3 more
openaire   +2 more sources

A Multifaceted Interplay Among Hemophagocytosis, Interleukin‐18, and Type I Interferon Distinguishes Still Disease From Other Autoinflammatory Diseases

Arthritis &Rheumatology, EarlyView.
Objective The unknown pathophysiology and the lack of specific features for systemic juvenile idiopathic arthritis and adult‐onset Still disease (collectively known as Still disease; SD) delay diagnosis and appropriate treatment. The goal of this study was to identify features and mechanisms that distinguish SD from other systemic autoinflammatory ...
Yvonne M. Mueller, Charlotte Girard, Harmen J. G. van de Werken, Stefan J. Erkeland, Dwin G. B. Grashof, Laurie Vaillant, Renske J. H. den Dekker, Iris van Zuijen, Sharon Veenbergen, Fanny Coffin, Eric Bindels, Yvan Jamilloux, Katerina Laskari, Vassili Soumelis, Bruno Fautrel, Cem Gabay, Peter D. Katsikis   +16 more
wiley   +1 more source

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source

Trisomy 8 defines a distinct subtype of myeloproliferative neoplasms driven by the MYC-alarmin axis [PDF]

Despite advances in understanding the genetic abnormalities in myeloproliferative neoplasms (MPNs) and the development of JAK2 inhibitors, there is an urgent need to devise new treatment strategies, particularly for triple negative myelofibrosis (MF ...
Su, Siyuan, Yun, Seongseok, Nakanishi, Shima, Razabdouski, Tiffany N., Cheng, Chia- Ho, Cory, Suzanne, Lee, Dae Hyun, Chan, Onyee, Patel, Parth C., Kuykendall, Andrew T., Vincelette, Nicole D., Zhang, Ling, Sammut, Rinzine, Eksioglu, Erika A., Lawrence, Harshani R., Yu, Xiaoqing, Komrokji, Rami S., Lee, Daesung, Kaufmann, Scott H., Cleveland, John L., Murphy, Daniel J., Mo, Qianxing, Nguyen, Hai Vu, Al Ali, Najla, Moon, Jungwon, Ferreira, Renan B.   +25 more
core   +1 more source

Exercise‐specific plasma proteomic signatures in racehorses: Candidates for training adaptation and peak load monitoring

Equine Veterinary Journal, EarlyView.
Abstract Background Racehorses undergo profound physiological changes with training and competition, but current biomarkers inadequately capture the complex molecular dynamics of exercise. This study aimed to identify novel plasma biomarkers of training adaptation and peak load using high‐throughput proteomics.
Jowita Grzędzicka, Bianka Świderska, Ewa Sitkiewicz, Izabela Dąbrowska, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

The alarmin IL33 orchestrates type 2 immune-mediated control of thymus regeneration [PDF]

, 2023
As the primary site of T-cell development, the thymus dictates immune competency of the host. The rates of thymus function are not constant, and thymus regeneration is essential to restore new T-cell production following tissue damage from environmental ...
White, Andrea J., Parnell, Sonia M., Anderson, Graham, Bacon, Andrea, McKenzie, Andrew N. J., Jenkinson, W. E.; id_orcid, Cosway, Emilie J., James, Kieran D.   +7 more
core   +1 more source

The Multitasking Potential of Alarmins and Atypical Chemokines [PDF]

Frontiers in Medicine, 2019
When the human genome was sequenced, it came as a surprise that it contains "only" 21,306 protein-coding genes. However, complexity and diversity are multiplied by alternative splicing, non-protein-coding transcripts, or post-translational modifications (PTMs) on proteome level.
Aphrodite Kapurniotu, Ozgun Gokce, Jürgen Bernhagen, Jürgen Bernhagen, Jürgen Bernhagen   +4 more
openaire   +4 more sources

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source