Results 21 to 30 of about 10,647 (207)

TSLP and asthma: fellow travelers [PDF]

Exploration of Asthma & Allergy, 2023
The incidence of asthma, a heterogeneous inflammatory disease affecting over 300 million people worldwide, continues to increase in developed countries.
David El-Qutob, Antonio Letran
doaj   +1 more source

A key role for NLRP3 signaling in preterm labor and birth driven by the alarmin S100B

, 2023
Preterm birth remains the leading cause of neonatal morbidity and mortality worldwide. A substantial number of spontaneous preterm births occur in the context of sterile intra-amniotic inflammation, a condition that has been mechanistically proven to be ...
Adi L. Tarca, Done, Bogdan, Tarca, Adi L., Arenas-Hernandez, Marcia, Garcia-Flores, Valeria, Miller, Derek, Bogdan Done, Motomura, Kenichiro, Romero, Roberto, Tao, Li, Jose Galaz, Roberto Romero, Zhenjie Liu, Yi Xu, Gomez-Lopez, Nardhy, Kanninen, Tomi, Liu, Zhenjie, Xu, Yi, Galaz, Jose, Derek Miller, Valeria Garcia-Flores, Marcelo Farias-Jofre, Tomi Kanninen, Li Tao, Nardhy Gomez-Lopez, Farias-Jofre, Marcelo, Marcia Arenas-Hernandez, Kenichiro Motomura   +27 more
core   +1 more source

Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis [PDF]

, 2020
Summary Functional contributions of individual cellular components of the bone-marrow microenvironment to myelofibrosis (MF) in patients with myeloproliferative neoplasms (MPNs) are incompletely understood. We aimed to generate a comprehensive map of the
Gütgemann, Ines, Krebs, Philippe, Tai, Evelyn Wing Yin, Leimkühler, Nils B., Fuchs, Stijn N.R., Snoeren, Inge A.M., Crysandt, Martina, Koschmieder, Steffen, Kramann, Rafael, Ronghui, Li, Schneider, Rebekka K., Vogl, Thomas, Brümmendorf, Tim H., Tai, Evelyn Wing-Ying, Banjanin, Bella, Kuppe, Christoph, Stalmann, Ursula S.A., Büsche, Guntram, Boor, Peter, Banz, Yara, Lam, King H., Kreipe, Hans, Bindels, Eric, Costa, Ivan G., Nagai, James S., Gleitz, Hélène F.E., Kreipe, H. (Hans), Banjanin, B. (Bella), Büsche, G. (Guntram), Leimkühler, N.B. (Nils B.), Vogl, T. (Thomas), Kuppe, C. (Christoph), Schneider-Kramann, R.K.M. (Rebekka), Ronghui, L. (Li), Boor, P. (Peter), Fuchs, S.N.R. (Stijn N.R.), Crysandt, M. (Martina), Brummendorf, T.H. (Tim), Nagai, J.S. (James S.), Krebs, P. (Philippe), Banz, Y. (Yara), Kramann, R.J.T. (Rafael), Costa, I.G. (Ivan G.), Gütgemann, I. (Ines), Lam, K.H. (King H.), Bindels, E.M.J. (Eric), Tai, E.W.-Y. (Evelyn Wing-Yin), Snoeren, I.A.M. (Inge A.M.), Gleitz, H.F.E. (Hélène), Koschmieder, S. (Steffen), Stalmann, U.S.A. (Ursula S.A.), Guntram Büsche, Eric Bindels, Li Ronghui, Hans Kreipe, Steffen Koschmieder, King H. Lam, Inge A.M. Snoeren, Bella Banjanin, Yara Banz, Evelyn Wing-Yin Tai, Thomas Vogl, Ursula S.A. Stalmann, Rebekka K. Schneider, Martina Crysandt, Ines Gütgemann, Nils B. Leimkühler, Christoph Kuppe, Hélène F.E. Gleitz, James S. Nagai, Ivan G. Costa, Philippe Krebs, Tim H. Brümmendorf, Rafael Kramann, Stijn N.R. Fuchs, Peter Boor   +75 more
core   +4 more sources

Tumor necrosis factor is a necroptosis-associated alarmin

Frontiers in Immunology, 2022
Necroptosis is a form of regulated cell death that can occur downstream of several immune pathways. While previous studies have shown that dysregulated necroptosis can lead to strong inflammatory responses, little is known about the identity of the ...
Francesca Pinci, Moritz M. Gaidt, Christophe Jung, Dennis Nagl, Gunnar Kuut, Veit Hornung   +5 more
doaj   +1 more source

Replicating viral vector platform exploits alarmin signals for potent CD8+ T cell-mediated tumour immunotherapy [PDF]

, 2017
Viral infections lead to alarmin release and elicit potent cytotoxic effector T lymphocyte (CTLeff) responses. Conversely, the induction of protective tumour-specific CTLeff and their recruitment into the tumour remain challenging tasks.
Kreutzfeldt, Mario, Darbre, Stephanie, Bonilla, Weldy V., Page, Nicolas, Kreuzaler, Matthi, Kallert, Sandra M., Loehning, Max, Mueller, Philipp   +7 more
core   +2 more sources

Inhibition of miR-378a-3p by Inflammation Enhances IL-33 Levels: A Novel Mechanism of Alarmin Modulation in Ulcerative Colitis

Frontiers in Immunology, 2019
Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) characterized by mucosa damage associated with an uncontrolled inflammatory response. This immunological impairment leads to altered inflammatory mediators such as IL-33, which is shown to ...
Karen Dubois-Camacho, David Diaz-Jimenez, David Diaz-Jimenez, Marjorie De la Fuente, Marjorie De la Fuente, Rodrigo Quera, Daniela Simian, Maripaz Martínez, Glauben Landskron, Mauricio Olivares-Morales, John A. Cidlowski, Xiaojiang Xu, Guangping Gao, Jun Xie, Jonás Chnaiderman, Ricardo Soto-Rifo, María-Julieta González, Andrea Calixto, Andrea Calixto, Marcela A. Hermoso   +19 more
doaj   +1 more source

Endogenous Interleukin-33 Acts as an Alarmin in Liver Ischemia-Reperfusion and Is Associated With Injury After Human Liver Transplantation

Frontiers in Immunology, 2021
Ischemia and reperfusion injury is an early inflammatory process during liver transplantation that impacts on graft function and clinical outcomes. Interleukin (IL)-33 is a danger-associated molecular pattern involved in kidney ischemia/reperfusion ...
Louise Barbier, Louise Barbier, Louise Barbier, Louise Barbier, Aurélie Robin, Aurélie Robin, Aurélie Robin, Rémy Sindayigaya, Rémy Sindayigaya, Rémy Sindayigaya, Rémy Sindayigaya, Héloïse Ducousso, Héloïse Ducousso, Héloïse Ducousso, Héloïse Ducousso, Fanny Dujardin, Antoine Thierry, Antoine Thierry, Antoine Thierry, Antoine Thierry, Antoine Thierry, Thierry Hauet, Thierry Hauet, Thierry Hauet, Thierry Hauet, Thierry Hauet, Jean-Philippe Girard, Luc Pellerin, Luc Pellerin, Luc Pellerin, Jean-Marc Gombert, Jean-Marc Gombert, Jean-Marc Gombert, Jean-Marc Gombert, Jean-Marc Gombert, André Herbelin, André Herbelin, André Herbelin, Ephrem Salamé, Ephrem Salamé, Ephrem Salamé, Ephrem Salamé   +41 more
doaj   +1 more source

The transcription of the alarmin cytokine interleukin-1 alpha is controlled by hypoxia inducible factors 1 and 2 alpha in hypoxic cells

Frontiers in Immunology, 2012
During hypoxia, cells undergo transcriptional changes to adjust to metabolic stress, to promote cell survival and to induce pro-angiogenic factors. Hypoxia induced factors (HIFs) regulate these transcriptional alterations.
Peleg eRider, Irena eKaplanov, Marianna eRomzova, Liora eBernardis, Alex eBraiman, Elena eVoronov, Ron Nathan Apte   +6 more
doaj   +1 more source

Nonspecific cytotoxic cell antimicrobial protein (NCAMP-1): a novel alarmin ligand identified in zebrafish. [PDF]

, 2015
Cells from the coelomic cavity of adult zebrafish (zf) were used to study the alarmin-like activities of nonspecific cytotoxic cell antimicrobial protein-1 (NCAMP-1).
Krunkosky Thomas, Donald Lee Evans, Monette Margaret Mariscal, Margaret Mariscal Monette, Liliana Jaso-Friedmann, Camus Alvin, Thomas Krunkosky, Alvin Camus, Evans Donald Lee, Jaso-Friedmann Liliana   +9 more
core   +1 more source

Innate Lymphoid Cells in Helminth Infections—Obligatory or Accessory?

Frontiers in Immunology, 2019
ILCs burst onto the immunological scene with their involvement in bacterial and helminth infections. As their influence has emerged, it has become clear that they play a fundamental role in regulating barrier tissue homeostasis and the immune response ...
Stephan Löser, Katherine A. Smith, Katherine A. Smith, Rick M. Maizels   +3 more
doaj   +1 more source