Results 11 to 20 of about 10,647 (207)

Role of alarmin cytokines and microRNAs in the host-schistosome interaction [version 1; referees: 3 approved] [PDF]

F1000Research, 2018
Schistosomiasis is a serious but neglected tropical infectious disease, afflicting more than 240 million people in 78 countries. Lack of an effective vaccine and obscuring disease mechanism could be the main hurdles to effectively control and eradicate ...
Xing He, Weiqing Pan
doaj   +2 more sources

Early Growth Response 1‐Associated Epithelial Autophagy‐Related Changes in Allergic Airway Inflammation [PDF]

Pediatric Discovery, EarlyView.
House dust mite (HDM) exposure induces early growth response 1 (EGR1) expression in airway epithelial cells and is accompanied by autophagy‐associated alterations, including increased LC3B‐II and Vps34 levels and decreased p62 abundance. Manipulation of EGR1 expression modulates these autophagy‐related changes, whereas pharmacological inhibition of ...
Xinyang Wang, Jie Ren, Yan Zhao, Zhengxiu Luo   +3 more
wiley   +2 more sources

The alarmin–ILC2 axis as a candidate mechanism for persistent olfactory dysfunction in allergic rhinitis [PDF]

Frontiers in Immunology
BackgroundAllergic rhinitis (AR) is an underrecognized contributor to olfactory dysfunction (OD). Although smell loss in AR is commonly attributed to conductive obstruction, some patients exhibit persistent or disproportionate hyposmia despite ...
Jin-xiang Zhu, Jin-xiang Zhu, Hao-ran Luo, Dan Li, Biao-qing Lu, Biao-qing Lu, Wei-juan Zhang, Guan-jiang Huang, Guan-jiang Huang, Yan Ruan, Yan Ruan   +10 more
doaj   +2 more sources

Interleukin-33 at the intersection of inflammation and repair [PDF]

Frontiers in Allergy
Interleukin 33 (IL-33) is a cytokine of the IL-1 family that acts as an alarmin in both innate and adaptive immunity. IL-33 is constitutively nuclear in epithelial and endothelial cells, where its activity is limited by nuclear retention.
Fernanda Martinez-Moreno, Elina Jerschow, Victor E. Ortega, Hirohito Kita, Sergio E. Chiarella   +4 more
doaj   +2 more sources

Reframing paucigranulocytic asthma through genetic endotyping: a hypothesis-generating focus on the 17q21 rs7216389 locus [PDF]

Curr Opin Allergy Clin Immunol
Purpose of review: Non-T2 asthma is currently defined by missing parameters, such as low blood eosinophils and FeNO, rather than positively identifiable mechanistic features. This definition overlaps with paucigranulocytic asthma (PGA).
Breda, Daniela, Varricchi, Gilda, Burastero, Samuele E, Poto, Remo, Chan, Rory, Burastero, Samuele E., Chan, Rory; id_orcid   +6 more
core   +2 more sources

Heme Oxygenase Protects against Placental Vascular Inflammation and Abortion by the Alarmin Heme in Mice. [PDF]

, 2020
Both infectious as non-infectious inflammation can cause placental dysfunction and pregnancy complications. During the first trimester of human gestation, when palatogenesis takes place, intrauterine hematoma and hemorrhage are common phenomena, causing ...
Christiaan M. Suttorp, Suttorp, Christiaan M, van Rheden, Rene E. M., Suttorp, Christiaan M., Kuijpers-Jagtman, Anne Marie; id_orcid, Helmich, M.P.A.C., van Dijk, Natasja W. M., René E. M. van Rheden, Helmich, Maria P. A. C., Wagener, F.A.D.T.G., Rheden, R.E.M. van, Dijk, N.W.M. van, Wagener, Frank A D T G, Anne Marie Kuijpers-Jagtman, Frank A. D. T. G. Wagener, Wagener, Frank A. D. T. G., Helmich, Maria P A C, Kuijpers-Jagtman, Anne Marie, Maria P. A. C. Helmich, van Rheden, René E M, van Dijk, Natasja W M, Suttorp, C.M., Kuijpers-Jagtman, A.M., Natasja W. M. van Dijk   +23 more
core   +3 more sources

Airway epithelial type‐2 alarmin profiles: Blood eosinophil counts remain in memory

, 2023
International audienceEpithelial cytokines are involved in the orchestration of T1/T2 inflammatory patterns. We question the persistence of this trait in air-liquid interface (ALI) epithelial cultures and whether this local orientation can be related to ...
Jeremy Charriot, Aurélie Petit, Knabe, Lucie, Carey Suehs, Charriot, Jérémy, Vernisse, Charlotte, Bedin, Anne Sophie, Charlotte Vernisse, Edouard Tuaillon, Pascal Chanez, Gras, Delphine, Arnaud Bourdin, Bourdin, Arnaud, Suehs, Carey, Tuaillon, Edouard, Delphine Gras, Petit, Aurélie, Anne Sophie Bedin, Vachier, Isabelle, Lucie Knabe, Chanez, Pascal, Isabelle Vachier   +21 more
core   +1 more source

IL33/ST2 Axis in Diabetic Kidney Disease: A Literature Review

Medicina, 2019
Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 family, playing a role in inflammatory, infectious and autoimmune diseases and expressed in the cellular nucleus in several tissues.
Alessandro Tonacci, Paolina Quattrocchi, Sebastiano Gangemi   +2 more
doaj   +1 more source

Early activation and recruitment of invariant natural killer T cells during liver ischemia-reperfusion: the major role of the alarmin interleukin-33

Frontiers in Immunology, 2023
Over the past thirty years, the complexity of the αβ-T cell compartment has been enriched by the identification of innate-like T cells (ITCs), which are composed mainly of invariant natural killer T (iNKT) cells and mucosal-associated invariant T (MAIT ...
Aurélie Robin, Claire Mackowiak, Romain Bost, Fanny Dujardin, Alice Barbarin, Antoine Thierry, Thierry Hauet, Luc Pellerin, Jean-Marc Gombert, Ephrem Salamé, André Herbelin, Louise Barbier   +11 more
doaj   +1 more source

Alarmins from conjunctival fibroblasts up-regulate matrix metalloproteinases in corneal fibroblasts [PDF]

International Journal of Ophthalmology, 2020
AIM: To explore the effects of alarmins produced by necrotic human conjunctival fibroblasts on the release of matrix metalloproteinases (MMPs) by human corneal fibroblasts (HCFs).
Lin Chen, Ye Liu, Xiao-Shuo Zheng, Hui Zheng, Ping-Ping Liu, Xiu-Xia Yang, Yang Liu   +6 more
doaj   +1 more source