Results 11 to 20 of about 8,634 (215)

Heme Oxygenase Protects against Placental Vascular Inflammation and Abortion by the Alarmin Heme in Mice. [PDF]

, 2020
Both infectious as non-infectious inflammation can cause placental dysfunction and pregnancy complications. During the first trimester of human gestation, when palatogenesis takes place, intrauterine hematoma and hemorrhage are common phenomena, causing ...
Christiaan M. Suttorp, Suttorp, Christiaan M, van Rheden, Rene E. M., Suttorp, Christiaan M., Kuijpers-Jagtman, Anne Marie; id_orcid, Helmich, M.P.A.C., van Dijk, Natasja W. M., René E. M. van Rheden, Helmich, Maria P. A. C., Wagener, F.A.D.T.G., Rheden, R.E.M. van, Dijk, N.W.M. van, Wagener, Frank A D T G, Anne Marie Kuijpers-Jagtman, Frank A. D. T. G. Wagener, Wagener, Frank A. D. T. G., Helmich, Maria P A C, Kuijpers-Jagtman, Anne Marie, Maria P. A. C. Helmich, van Rheden, René E M, van Dijk, Natasja W M, Suttorp, C.M., Kuijpers-Jagtman, A.M., Natasja W. M. van Dijk   +23 more
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Targeting alarmin release reverses Sjogren's syndrome phenotype by revitalizing Ca2+ signalling [PDF]

, 2023
Background Primary Sjogren's syndrome (pSS) is a systemic autoimmune disease that is embodied by the loss of salivary gland function and immune cell infiltration, but the mechanism(s) are still unknown.
Yuyang Sun, Brij B. Singh, Pooja Chauhan, Julian L. Ambrus, Chauhan, Arun, Bibhuti B. Mishra, Singh, Brij B, Viviane Nascimento Da Conceicao, Ambrus, Julian L, Frans G. M. Kroese, Madesh Muniswamy, Arun Chauhan, Pramod Sukumaran, Nascimento Da Conceicao, Viviane, Kroese, Frans G M, Mishra, Bibhuti B, Muniswamy, Madesh, Sukumaran, Pramod, Arjan Vissink, Vissink, Arjan, Vissink, Arjan; id_orcid, Chauhan, Pooja, Sun, Yuyang   +22 more
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Replicating viral vector platform exploits alarmin signals for potent CD8+ T cell-mediated tumour immunotherapy [PDF]

, 2017
Viral infections lead to alarmin release and elicit potent cytotoxic effector T lymphocyte (CTLeff) responses. Conversely, the induction of protective tumour-specific CTLeff and their recruitment into the tumour remain challenging tasks.
Kreutzfeldt, Mario, Darbre, Stephanie, Bonilla, Weldy V., Page, Nicolas, Kreuzaler, Matthi, Kallert, Sandra M., Loehning, Max, Mueller, Philipp   +7 more
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Alarmins and antimicrobial immunity [PDF]

Medical Mycology, 2009
Alarmins are endogenous mediators capable of enhancing innate and adaptive immune response through induction of concomitant recruitment and activation of antigen-presenting cells. Here we provide a brief overview of various alarmins, highlight their critical roles in innate and adaptive antimicrobial immunity, and speculate on potential usage of ...
D, Yang, J J, Oppenheim
openaire   +2 more sources

Alarmins: Feel the Stress [PDF]

The Journal of Immunology, 2017
Abstract Over the last decade, danger-associated molecular pattern molecules, or alarmins, have been recognized as signaling mediators of sterile inflammatory responses after trauma and injury. In contrast with the accepted passive release models suggested by the “danger hypothesis,” it was recently shown that alarmins can also directly ...
Rider, P., Voronov, E., Dinarello, C.A., Dinarello, C.A., Apte, R.N., Cohen, I.   +5 more
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Airway epithelial type‐2 alarmin profiles: Blood eosinophil counts remain in memory

, 2023
International audienceEpithelial cytokines are involved in the orchestration of T1/T2 inflammatory patterns. We question the persistence of this trait in air-liquid interface (ALI) epithelial cultures and whether this local orientation can be related to ...
Jeremy Charriot, Aurélie Petit, Knabe, Lucie, Carey Suehs, Charriot, Jérémy, Vernisse, Charlotte, Bedin, Anne Sophie, Charlotte Vernisse, Edouard Tuaillon, Pascal Chanez, Gras, Delphine, Arnaud Bourdin, Bourdin, Arnaud, Suehs, Carey, Tuaillon, Edouard, Delphine Gras, Petit, Aurélie, Anne Sophie Bedin, Vachier, Isabelle, Lucie Knabe, Chanez, Pascal, Isabelle Vachier   +21 more
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Role of alarmin cytokines and microRNAs in the host-schistosome interaction [version 1; referees: 3 approved] [PDF]

, 2018
Schistosomiasis is a serious but neglected tropical infectious disease, afflicting more than 240 million people in 78 countries. Lack of an effective vaccine and obscuring disease mechanism could be the main hurdles to effectively control and eradicate ...
Xing He, Weiqing Pan
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A key role for NLRP3 signaling in preterm labor and birth driven by the alarmin S100B

, 2023
Preterm birth remains the leading cause of neonatal morbidity and mortality worldwide. A substantial number of spontaneous preterm births occur in the context of sterile intra-amniotic inflammation, a condition that has been mechanistically proven to be ...
Adi L. Tarca, Done, Bogdan, Tarca, Adi L., Arenas-Hernandez, Marcia, Garcia-Flores, Valeria, Miller, Derek, Bogdan Done, Motomura, Kenichiro, Romero, Roberto, Tao, Li, Jose Galaz, Roberto Romero, Zhenjie Liu, Yi Xu, Gomez-Lopez, Nardhy, Kanninen, Tomi, Liu, Zhenjie, Xu, Yi, Galaz, Jose, Derek Miller, Valeria Garcia-Flores, Marcelo Farias-Jofre, Tomi Kanninen, Li Tao, Nardhy Gomez-Lopez, Farias-Jofre, Marcelo, Marcia Arenas-Hernandez, Kenichiro Motomura   +27 more
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Hypo-osmotic stress induces the epithelial alarmin IL-33 in the colonic barrier of ulcerative colitis [PDF]

, 2022
Epithelial alarmins are gaining interest as therapeutic targets for chronic inflammation. The nuclear alarmin interleukin-33 (IL-33) is upregulated in the colonic mucosa of acute ulcerative colitis (UC) and may represent an early instigator of the ...
Gundersen, Mona Dixon, Johnsen, Kay-Martin, Haraldsen, Guttorm, Johnsen, Kay Martin, Florholmen, Jon, Larsen, Kenneth Bowitz, Goll, Rasmus   +6 more
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Tumors Sound the Alarmin(s) [PDF]

Cancer Research, 2008
Abstract Recent evidence suggests that inflammatory molecules play critical roles in the development and progression of numerous tumors. However, one specific group of inflammatory molecules whose importance has been established in host immune responses, termed alarmins, has been largely overlooked in cancer biology.
Seth B, Coffelt, Aline B, Scandurro
openaire   +2 more sources