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Unveiling the multifaceted antitumor effects of interleukin 33 [PDF]
Frontiers in ImmunologyInterleukin 33 (IL-33), once predominantly recognized for its pro-tumoral activities, has emerged as a multifunctional cytokine with antitumor properties.
Leire Arrizabalaga +10 more
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Interleukin-33 and Obesity-Related Inflammation and Cancer [PDF]
EncyclopediaInterleukin-33 (IL-33) is a cytokine belonging to the IL-1 family. It is primarily associated with type 2 immune responses. It interacts with a receptor complex on immune cells in reaction to tissue damage or cellular injury.
Cameron Kowitt, Qiuyang Zhang
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Interleukin‐33‐Mediated Mechanical‐Loading Induced Degeneration of Knee Joint Chondrocytes [PDF]
FASEB BioAdvancesOsteoarthritis (OA), a common degenerative joint disorder, continued to present significant challenges in clinical management due to an incomplete understanding of its pathogenesis.
Jiahui Zhang +5 more
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Interleukin-33 (IL-33) promotes DNA damage-resistance in lung cancer [PDF]
Cell Death and DiseaseResistance to DNA damage is one of the primary mechanisms by which tumor cells evade the effects of standard chemotherapeutic agents and radiotherapy. Dynamic and complex interactions between the tumor microenvironment (TME) and tumor cells critically ...
Haoge Luo +7 more
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Interleukin-33 regulates the functional state of microglia
Frontiers in Cellular Neuroscience, 2022 Microglia, the most prominent resident immune cells, exhibit multiple functional states beyond their immunomodulatory roles. Non-immune functions such as synaptic reorganization, removal of cellular debris, and deposition of abnormal substances are ...
Tianqing Xiong +5 more
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Biological mechanisms and therapeutic prospects of interleukin-33 in pathogenesis and treatment of allergic disease [PDF]
Journal of InflammationAllergic diseases significantly impact the quality of life of people around the world. Cytokines play a crucial role in regulating the immune system. Due to their importance in pro-inflammatory mechanisms, cytokines are used to understand pathogenesis ...
Mohammad Chand Jamali +10 more
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Interleukin-33: A Double-Edged Sword in Sepsis. [PDF]
Transl Perioper Pain MedDespite some advances that have been made in the clinical management of sepsis, its morbidity and mortality rates remain high. The pathogenesis of systemic inflammation and organ damage leading to septic mortality is not fully understood. Interleukin-33 (IL-33), a new member of the IL-1 superfamily, can be a traditional cytokine and a nuclear factor ...
Liu S, Yue Y, Wu Q, Zhang LM.
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Interleukin-33 in Systemic Sclerosis: Expression and Pathogenesis
Frontiers in Immunology, 2018 Interleukin-33 (IL-33), a member of the IL-1 superfamily, functions as a traditional cytokine and nuclear factor. It is proposed to have an “alarmin” role. IL-33 mediates biological effects by interacting with the ST2 receptor and IL-1 receptor accessory
Liya Li +5 more
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Interleukin 33: a suitable target for biological therapies of COPD? [PDF]
ERJ Open ResearchCorrado Pelaia
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Interleukin‐33 in allergy [PDF]
Allergy, 2012 AbstractInterleukin‐33 (IL‐33) is a member of the IL‐1 cytokine family, which includes IL‐1 and IL‐18, and is considered to be important for host defense against nematodes by inducing Th2 cytokine production via the IL‐33 receptor. IL‐33 receptor is a heterodimer of IL‐1 receptor‐like 1 (IL‐1RL1; also called ST2, T1, Der4, and fit‐1) and IL‐1 receptor ...
Tatsukuni, Ohno +4 more
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