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Unveiling the multifaceted antitumor effects of interleukin 33 [PDF]

Frontiers in Immunology
Interleukin 33 (IL-33), once predominantly recognized for its pro-tumoral activities, has emerged as a multifunctional cytokine with antitumor properties.
Leire Arrizabalaga, Leire Arrizabalaga, Aline Risson, Aline Risson, Miriam Ezcurra-Hualde, Miriam Ezcurra-Hualde, Fernando Aranda, Fernando Aranda, Pedro Berraondo, Pedro Berraondo, Pedro Berraondo   +10 more
doaj   +4 more sources

Interleukin-33 and Obesity-Related Inflammation and Cancer [PDF]

Encyclopedia
Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 family. It is primarily associated with type 2 immune responses. It interacts with a receptor complex on immune cells in reaction to tissue damage or cellular injury.
Cameron Kowitt, Qiuyang Zhang
doaj   +4 more sources

Interleukin‐33‐Mediated Mechanical‐Loading Induced Degeneration of Knee Joint Chondrocytes [PDF]

FASEB BioAdvances
Osteoarthritis (OA), a common degenerative joint disorder, continued to present significant challenges in clinical management due to an incomplete understanding of its pathogenesis.
Jiahui Zhang, Yao Sun, Tongtong Chen, Hanqi Wang, Changwei Li, Yong Lu   +5 more
doaj   +2 more sources

Interleukin 33 regulates the autophagy of oxygen-glucose-deprivation/reoxygenation microglia via macrophage polarization [PDF]

Central European Journal of Immunology
Introduction Interleukin (IL)-33 is a pleiotropic cytokine in the immune system and inflammatory responses, which is involved in cerebral ischemia/reperfusion (I/R) injury.
Yong Fan, Lili Lin, Kailiang Huang, Jinying Lin, Junping Xu, Xiaohui Zhou, Yongkai Yang   +6 more
doaj   +2 more sources

Interleukin-33 (IL-33) promotes DNA damage-resistance in lung cancer [PDF]

Cell Death and Disease
Resistance to DNA damage is one of the primary mechanisms by which tumor cells evade the effects of standard chemotherapeutic agents and radiotherapy. Dynamic and complex interactions between the tumor microenvironment (TME) and tumor cells critically ...
Haoge Luo, Liping Liu, Xiaoping Liu, Yingdong Xie, Xin Huang, Ming Yang, Chen Shao, Dong Li   +7 more
doaj   +2 more sources

Interleukin-33 regulates the functional state of microglia

Frontiers in Cellular Neuroscience, 2022
Microglia, the most prominent resident immune cells, exhibit multiple functional states beyond their immunomodulatory roles. Non-immune functions such as synaptic reorganization, removal of cellular debris, and deposition of abnormal substances are ...
Tianqing Xiong, Tianqing Xiong, Xingyi Wang, Yiwen Zha, Yingge Wang, Yingge Wang   +5 more
doaj   +3 more sources

Biological mechanisms and therapeutic prospects of interleukin-33 in pathogenesis and treatment of allergic disease [PDF]

Journal of Inflammation
Allergic diseases significantly impact the quality of life of people around the world. Cytokines play a crucial role in regulating the immune system. Due to their importance in pro-inflammatory mechanisms, cytokines are used to understand pathogenesis ...
Mohammad Chand Jamali, Asma’a H. Mohamed, Azfar Jamal, Mohammad Azhar Kamal, Waleed Al Abdulmonem, Bashar Abdullah Saeed, Nasrin Mansuri, Fuzail Ahmad, Mustafa Mudhafar, Alaa Shafie, Haroonrashid M. Hattiwale   +10 more
doaj   +2 more sources

Interleukin-33 in Systemic Sclerosis: Expression and Pathogenesis

Frontiers in Immunology, 2018
Interleukin-33 (IL-33), a member of the IL-1 superfamily, functions as a traditional cytokine and nuclear factor. It is proposed to have an “alarmin” role. IL-33 mediates biological effects by interacting with the ST2 receptor and IL-1 receptor accessory
Liya Li, Liya Li, Honglin Zhu, Honglin Zhu, Xiaoxia Zuo, Xiaoxia Zuo   +5 more
doaj   +3 more sources

Interleukin-33: A Double-Edged Sword in Sepsis. [PDF]

Transl Perioper Pain Med
Despite some advances that have been made in the clinical management of sepsis, its morbidity and mortality rates remain high. The pathogenesis of systemic inflammation and organ damage leading to septic mortality is not fully understood. Interleukin-33 (IL-33), a new member of the IL-1 superfamily, can be a traditional cytokine and a nuclear factor ...
Liu S, Yue Y, Wu Q, Zhang LM.
europepmc   +3 more sources

Serum Level of IL-33 in Vitiligo [PDF]

Zagazig University Medical Journal, 2023
Background: Vitiligo is a commonly acquired depigmentation disorder of the skin, related to the loss of functioning melanocytes or melanin in the epidermis or mucosa, or/and hair folliculi.
Naglaa Khalifa, Al-Shimaa Ibrahim, Mahmoud Abdel-Mawla, Rania Abd El-karim   +3 more
doaj   +1 more source