Results 31 to 40 of about 7,888 (200)
Frontiers in Immunology, 2012 During hypoxia, cells undergo transcriptional changes to adjust to metabolic stress, to promote cell survival and to induce pro-angiogenic factors. Hypoxia induced factors (HIFs) regulate these transcriptional alterations.
Peleg eRider +6 more
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Innate Lymphoid Cells in Helminth Infections—Obligatory or Accessory?
Frontiers in Immunology, 2019 ILCs burst onto the immunological scene with their involvement in bacterial and helminth infections. As their influence has emerged, it has become clear that they play a fundamental role in regulating barrier tissue homeostasis and the immune response ...
Stephan Löser +3 more
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Do advanced glycation end products contribute to food allergy?
Frontiers in Allergy, 2023 Sugars can bind non-enzymatically to proteins, nucleic acids or lipids and form compounds called Advanced Glycation End Products (AGEs). Although AGEs can form in vivo, factors in the Western diet such as high amounts of added sugars, processing methods ...
P. K. Smith +4 more
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Role of Alarmins in the Pathogenesis of Systemic Sclerosis [PDF]
International Journal of Molecular Sciences, 2020 Systemic sclerosis (SSc) is a rare chronic autoimmune disease associated with significant morbidity and mortality. Two main subsets of SSc are recognized: (i) diffuse cutaneous SSc with rapidly progressive fibrosis of the skin, lungs, and other internal organs; and (ii) limited cutaneous SSc, which is dominated by vascular manifestations, with skin and
Antonello Giovannetti +5 more
openaire +6 more sources
Frontiers in Immunology, 2022 Calreticulin is a chaperone, normally found in the endoplasmic reticulum, but can be released by macrophages into the extracellular medium. It is also found in cerebrospinal fluid bound to amyloid beta (Aβ).
Kyle M. Reid +4 more
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Alarmin‐induced cell migration [PDF]
European Journal of Immunology, 2013 Alarmins are endogenous, constitutively available, damage‐associated molecular patterns that upon release can mobilize and activate various leukocytes for the induction of innate and adaptive immune responses. For our immune system to function appropriately, it relies on navigating various leukocytes to distinct places at the right time.
De, Yang +4 more
openaire +2 more sources
Alarmins: awaiting a clinical response [PDF]
Journal of Clinical Investigation, 2012 Alarmins are endogenous molecules that are constitutively available and released upon tissue damage and activate the immune system. Current evidence indicates that uncontrolled and excessive release of alarmins contributes to the dysregulated processes seen in many inflammatory and autoimmune conditions, as well as tumorigenesis and cancer spread ...
Chan, James K +7 more
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The Involvement of Alarmins in the Pathogenesis of Sjögren’s Syndrome [PDF]
International Journal of Molecular Sciences, 2022 Sjögren’s syndrome (SS) is a chronic autoimmune disease that affects exocrine glands, primarily the salivary and lachrymal glands. It is characterized by lymphoplasmacytic infiltration of the glandular tissues, ultimately leading to their dysfunction and destruction. Besides classic dry eyes and dry mouth defined as sicca syndrome, patients affected by
Julie Sarrand +3 more
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Medicina, 2021 Mental disorders are common in the general population; every year about 25% of the total European population is affected by a mental condition. The prevalence of psychiatric disorders might be underestimated.
Gianluca Pandolfo +6 more
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Critical and diverse role of alarmin cytokines in parasitic infections
Frontiers in Cellular and Infection MicrobiologyAlarmin cytokines including IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) function as danger signals to trigger host immunity in response to tissue injury caused by pathogenic factors such as parasitic infections.
Zhou Xing, Suiyi Liu, Xing He
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