Results 31 to 40 of about 8,634 (215)

Calcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Cell Responses

, 2019
Neuroimmune interactions have emerged as critical modulators of allergic inflammation, and type 2 innate lymphoid cells (ILC2s) are an important cell type for mediating these interactions.
Burkett, Patrick R., Schnell, Alexandra, Tsujikawa, Kazutake, Thakore, Pratiksha I., Vijay K. Kuchroo, Kazutake Tsujikawa, Kuchroo, Vijay K., Elena Christian, Pratiksha I. Thakore, Alexandra Schnell, Bruce D. Levy, Patrick R. Burkett, Raja-Elie E. Abdulnour, Lambden, Conner, Levy, Bruce D., Se-Jin Kim, Samantha J. Riesenfeld, Ramnik J. Xavier, Herbst, Rebecca H., Antonia Wallrapp, Riesenfeld, Samantha J., Conner Lambden, Regev, Aviv, Isaac M. Chiu, Abdulnour, Raja-Elie E., Chiu, Isaac M., Khan, Pavana, Wallrapp, Antonia, Kim, Se-Jin, Rebecca H. Herbst, Xavier, Ramnik J., Pavana Khan, Christian, Elena, Aviv Regev   +33 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Targeting ANGPTL3 and IL‐33/ST2 Ameliorates Diabetic Kidney Disease by Reducing Lipotoxicity, Alleviating Inflammation and Inhibiting Fibrosis

Advanced Science, EarlyView.
Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...
Zhuojin Li, Zhonglian Cao, Rongrui Zhou, Xu Cheng, Xiaozhi Hu, Shuwen Xu, Zihan Dou, Ling Du, Dianwen Ju   +8 more
wiley   +1 more source

S100A8 & S100A9: alarmin mediated inflammation in tendinopathy [PDF]

, 2019
Alarmins S100A8 and S100A9 are endogenous molecules released in response to environmental triggers and cellular damage. They are constitutively expressed in immune cells such as monocytes and neutrophils and their expression is upregulated under ...
Cao, Hai Man, Kitson, Susan M., Akbar, Moeed, Millar, Neal L., Spencer, Simon J., Murrell, George A.C., Reilly, James H., Rooney, Brain P., Crowe, Lindsay A.N., Chambers, Max, Patommel, Katharina, Mullen, Michael, Garcia Melchor, Emma, McLean, Michael, McInnes, Iain B., Leach, William J.   +15 more
core   +1 more source

Allergic Rhinitis Amplifies Asthma Risk in Patients With Chronic Rhinosinusitis: A Large‐Scale Retrospective Cohort Analysis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) and allergic rhinitis (AR) are two highly prevalent airway diseases in the United States. While the coexistence of CRS and asthma is well recognized, less is known about the development of new‐onset asthma in CRS, particularly in the context of comorbid AR. This study assessed the impact of CRS and AR on
Austin J. Lee, Mohamad R. Chaaban
wiley   +1 more source

Alarmin function of galectin-9 in murine respiratory tularemia.

, 2015
Sepsis is a complex immune disorder that is characterized by systemic hyperinflammation. Alarmins, which are multifunctional endogenous factors, have been implicated in exacerbation of inflammation in many immune disorders including sepsis.
Jyotika Sharma, Bibhuti B Mishra, Dennis W Metzger, Anthony L Steichen, Tanner J Simonson, Sharon L Salmon   +5 more
core   +1 more source

Neuronal alarmin IL-1a evokes astrocyte-mediated protective signals: effectiveness in chemotherapy-induced neuropathic pain

, 2022
The distinction between glial painful and protective pathways is unclear and the possibility to finely modulate the system is lacking. Focusing on painful neuropathies, we studied the role of interleukin 1α (IL-1α), an alarmin belonging to the larger ...
Ghelardini C, Cervetto C, Lucarini E, Di Cesare Mannelli L, Toti A, Marcoli M, Parisio C, Micheli L   +7 more
core   +1 more source

Prothymosin Alpha: An Alarmin and More...

Current Medicinal Chemistry, 2017
Prothymosin alpha (proTα) is a ubiquitous polypeptide first isolated by Haritos in 1984, whose role still remains partly elusive. We know that proTα acts both, intracellularly, as an anti-apoptotic and proliferation mediator, and extracellularly, as a biologic response modifier mediating immune responses similarly to molecules termed as "alarmins". Our
Samara, P., Karachaliou, C.-E., Ioannou, K., Papaioannou, N.E., Voutsas, I.F., Zikos, C., Pirmettis, I., Papadopoulos, M., Kalbacher, H., Livaniou, E., Tsitsilonis, O.E., Voelter, W.   +11 more
openaire   +3 more sources

The alarmin interleukin-33 drives protective antiviral CD8⁺ T cell responses.

, 2012
Pathogen-associated molecular patterns decisively influence antiviral immune responses, whereas the contribution of endogenous signals of tissue damage, also known as damage-associated molecular patterns or alarmins, remains ill defined.
Schrick, Christina, Fröhlich, Anja, Bonilla, Weldy V., Senn, K., Klemenz, R., Johnson, S., Klemenz, Roman, Löhning, M., Fallon, Padraic G., Kreutzfeldt, M., Hegazy, A.N., Fernandez, M., Merkler, D., Bonilla, Weldy V, Löhning, Max, Fallon, Padraic G, Nakae, S., Kallert, Sandra, Pinschewer, D.D., Hegazy, Ahmed N, Schrick, C., Adler, Heiko, Kallert, S., Kreutzfeldt, Mario, Merkler, Doron, Bonilla, W.V., Fallon, P.G., Pinschewer, Daniel, Froehlich, Anja, Fröhlich, A., Nakae, Susumu, Pinschewer, Daniel D., Loehning, Max, Adler, H., Hegazy, Ahmed N., Fernandez, Marylise, Johnson, Susan, Senn, Karin   +37 more
core   +1 more source