Results 51 to 60 of about 8,634 (215)

Supplementary Figure -Supplemental material for Fragmented hyaluronan has no alarmin function assessed in arthritis synovial fibroblast and chondrocyte cultures

, 2018
Supplemental material, Supplementary Figure for Fragmented hyaluronan has no alarmin function assessed in arthritis synovial fibroblast and chondrocyte cultures by Mia Olsson, Lisa Bremer, Cecilia Aulin and Helena Erlandsson Harris in Innate ...
Helena Erlandsson Harris (32049), Mia Olsson (227252), Lisa Bremer (5323145), Cecilia Aulin (5323142)   +3 more
core   +1 more source

Redox-control of the alarmin, Interleukin-1α

Redox Biology, 2013
The pro-inflammatory cytokine Interleukin-1α (IL-1α) has recently emerged as a susceptibility marker for a wide array of inflammatory diseases associated with oxidative stress including Alzheimer's, arthritis, atherosclerosis, diabetes and cancer. In the present study, we establish that expression and nuclear localization of IL-1α are redox-dependent ...
Donald A. McCarthy, Aparna Ranganathan, Sita Subbaram, Nicole L. Flaherty, Nilay Patel, Mohamed Trebak, Nadine Hempel, J. Andrés Melendez   +7 more
openaire   +3 more sources

Targeting Inflammatory Alarmin S100A9 Modulates Activation of Pro‐Inflammatory Macrophage to Protect Nasal Epithelial Cells From LPS‐Induced Epithelial–Mesenchymal Transition

Microbiology and Immunology, EarlyView.
ABSTRACT Chronic rhinosinusitis with nasal polyps (CRSwNP) exhibits pronounced endotypic heterogeneity, with macrophages serving as key drivers of sustained mucosal inflammation. In this study, we identify S100A9 as a macrophage‐derived alarmin that is markedly elevated in CRSwNP tissues.
Yunxiang Ji, Jia Luan, Fang Yuan, Zhao Wang, Ran Wei, Guangbin Sun   +5 more
wiley   +1 more source

Memory CD8+ T Cell Protection From Viral Reinfection Depends on Interleukin-33 Alarmin Signals [PDF]

, 2019
Memory CD8+ cytotoxic T lymphocytes (CTLs) can protect against viral reinfection. However, the signals driving rapid memory CTL reactivation have remained ill-defined.
Vivien Holecska, Max Löhning, Tobias M. Brunner, Fröhlich, Anja, Anja Fröhlich, Pinschewer, Daniel D., Löhning, Max, Claudia Baumann, Baumann, Claudia, Brunner, Tobias M., Daniel D. Pinschewer, Holecska, Vivien   +11 more
core   +1 more source

Pro-fibrogenic role of alarmin high mobility group box 1 in HIV–hepatitis B virus coinfection

, 2022
20.500.12530/87852Liver disease is accelerated in people with HIV (PWH) with hepatitis B virus (HBV) coinfection. We hypothesized that liver fibrosis in HIV-HBV is triggered by increased hepatocyte apoptosis, microbial translocation and/or HIV/HBV viral ...
Singh, Kasha P, Chen, Antony, Pallett, Laura J, Fusai, Giuseppe, Kasha P. Singh, Massimo Pinzani, Harsimran Singh, Antony Chen, Itziar Otano, Mala K. Maini, Rombouts, Krista, Crane, Megan, Laura J. Pallett, Avihingsanon, Anchalee, Otano, Itziar, Marion Duriez, Sharon R. Lewin, Megan Crane, Lewin, Sharon R, Duriez, Marion, Giuseppe Fusai, Singh, Harsimran, Pinzani, Massimo, Anchalee Avihingsanon, Maini, Mala K, Krista Rombouts   +25 more
core   +1 more source

Red alert: labile heme is an alarmin [PDF]

Current Opinion in Immunology, 2016
Alarmins are a heterogeneous group of endogenous molecules that signal cellular damage when sensed extracellularly. Heme is an endogenous molecule that acts as a prosthetic group of hemoproteins, such as hemoglobin and myoglobin. When released from damaged red blood cells or muscle cells, oxidized hemoglobin and myoglobin release their prosthetic heme ...
Miguel P Soares, Marcelo T Bozza
openaire   +3 more sources

Sequence of Immunological Events During IgE‐Mediated Allergic Reactions to Food

Allergy, EarlyView.
ABSTRACT Food allergies (FA) represent a significant global health burden. Upon allergen re‐exposure, allergic patients exhibit a sequence of symptoms that vary in terms of affected organ systems, severity, time of onset and allergen reactivity thresholds.
N. A. Nagy, D. Schnoegl, V. Houghton, L. O'Mahony, A. F. Santos, E. F. Knol, A. Kuehn, T. Eiwegger   +7 more
wiley   +1 more source

Targeting Immunologic Pathways in Eosinophilic Granulomatosis With Polyangiitis: Translating Emerging Evidence Into Clinical Practice

Allergy, EarlyView.
ABSTRACT Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare and potentially life‐threatening systemic, inflammatory disease with multi‐organ manifestations, variable presentation and complex pathology. Multiple interconnected immunological pathways are implicated in EGPA pathology, including a type‐2 immune response driving predominantly ...
Harold Wilson‐Morkeh, Lior Seluk, Philipp Bosch, Carolina Aguiar, Jens Thiel, Bernhard Hellmich, Michael E. Wechsler, Salman Siddiqui   +7 more
wiley   +1 more source

TL1A: a novel alarmin in airway, intestinal, and autoimmune disorders

: The term alarmin denotes a broad class of molecules rapidly released to alert the immune system through the engagement of specific receptors on immune cells. Three alarmin cytokines, thymic stromal lymphopoietin (TSLP), IL-33, IL-25), are released from
Varricchi, Gilda, Marone, Gianni, Strisciuglio, Caterina, Poto, Remo, Nair, Parameswaran, Criscuolo, Gjada   +5 more
core   +1 more source

The Role of Alarmins in the Pathogenesis of Asthma

Biomolecules
Asthma is defined as a chronic respiratory disease, the processes of which are mainly related to the hyperreactivity of the immune system. Airway hyperresponsiveness and remodeling are other hallmarks of asthma that are strongly involved in the progression of the disease.
Paulina Plewa, Julia Pokwicka, Estera Bakinowska, Kajetan Kiełbowski, Andrzej Pawlik   +4 more
openaire   +3 more sources