Results 51 to 60 of about 7,888 (200)

Targeting ANGPTL3 and IL‐33/ST2 Ameliorates Diabetic Kidney Disease by Reducing Lipotoxicity, Alleviating Inflammation and Inhibiting Fibrosis

Advanced Science, EarlyView.
Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...
Zhuojin Li, Zhonglian Cao, Rongrui Zhou, Xu Cheng, Xiaozhi Hu, Shuwen Xu, Zihan Dou, Ling Du, Dianwen Ju   +8 more
wiley   +1 more source

Prothymosin Alpha: An Alarmin and More...

Current Medicinal Chemistry, 2017
Prothymosin alpha (proTα) is a ubiquitous polypeptide first isolated by Haritos in 1984, whose role still remains partly elusive. We know that proTα acts both, intracellularly, as an anti-apoptotic and proliferation mediator, and extracellularly, as a biologic response modifier mediating immune responses similarly to molecules termed as "alarmins". Our
Samara, P., Karachaliou, C.-E., Ioannou, K., Papaioannou, N.E., Voutsas, I.F., Zikos, C., Pirmettis, I., Papadopoulos, M., Kalbacher, H., Livaniou, E., Tsitsilonis, O.E., Voelter, W.   +11 more
openaire   +3 more sources

Matrix Stiffness Induces Endothelial Network Senescence

Advanced Science, EarlyView.
Using a 3D human in vitro model that decouples mechanical stress from inflammatory or biochemical signals, matrix stiffening induces a senescence phenotype in endothelial networks. This mechano‐induced senescence activates Notch signaling, and pharmacologic Notch inhibition attenuates this stiffness‐induced senescence.
Jiyeon Song, Alexandra N. Rindone, Ya Guan, Connor D. Amelung, Prarthana Sanjay Daswani, Jennifer H. Elisseeff, Sharon Gerecht   +6 more
wiley   +1 more source

Allergic Rhinitis Amplifies Asthma Risk in Patients With Chronic Rhinosinusitis: A Large‐Scale Retrospective Cohort Analysis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) and allergic rhinitis (AR) are two highly prevalent airway diseases in the United States. While the coexistence of CRS and asthma is well recognized, less is known about the development of new‐onset asthma in CRS, particularly in the context of comorbid AR. This study assessed the impact of CRS and AR on
Austin J. Lee, Mohamad R. Chaaban
wiley   +1 more source

Inflammatory Signatures Beyond Th1/Th2 Endotypes Provide Insights Into Postoperative Recurrence in Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) represents a spectrum of inflammatory endotypes, driven by distinct T helper (Th) immune responses. The high rate of recurrent disease despite appropriate medical and surgical interventions highlights the need for improved characterization beyond the traditional type 2 and non‐type 2 phenotypes to better
Liyona Kampel, Narin N. Carmel, Shaun Edalati, Hen Chaushu, Forsan Jahshan, Yaniv Hadi, Timur Pestrikov, Leonor Leider Trejo, Nidal Muhanna, Avraham Abergel   +9 more
wiley   +1 more source

Neuroinflammatory Biomarkers for Traumatic Brain Injury Diagnosis and Prognosis: A TRACK-TBI Pilot Study

Neurotrauma Reports, 2023
The relationship between systemic inflammation and secondary injury in traumatic brain injury (TBI) is complex. We investigated associations between inflammatory markers and clinical confirmation of TBI diagnosis and prognosis.
John K. Yue, Firas H. Kobeissy, Sonia Jain, Xiaoying Sun, Ryan R.L. Phelps, Frederick K. Korley, Raquel C. Gardner, Adam R. Ferguson, J. Russell Huie, Andrea L.C. Schneider, Zhihui Yang, Haiyan Xu, Cillian E. Lynch, Hansen Deng, Miri Rabinowitz, Mary J. Vassar, Sabrina R. Taylor, Pratik Mukherjee, Esther L. Yuh, Amy J. Markowitz, Ava M. Puccio, David O. Okonkwo, Ramon Diaz-Arrastia, Geoffrey T. Manley, Kevin K.W. Wang, Collaboration group, Collaboration group, Neeraj Badjatia, Brandon Foreman, Shankar Gopinath, Ramesh Grandhi, Ruchira M. Jha, Hester F. Lingsma, Christopher Madden, Debbie Y. Madhok, Michael A. McCrea, Randall Merchant, Lindsay D. Nelson, Laura B. Ngwenya, Claudia S. Robertson, Richard B. Rodgers, Gabriela G. Satris, David M. Schnyer, Alex B. Valadka, Thomas A. van Essen, Ross Zafonte   +45 more
doaj   +1 more source

A Multifaceted Interplay Among Hemophagocytosis, Interleukin‐18, and Type I Interferon Distinguishes Still Disease From Other Autoinflammatory Diseases

Arthritis &Rheumatology, EarlyView.
Objective The unknown pathophysiology and the lack of specific features for systemic juvenile idiopathic arthritis and adult‐onset Still disease (collectively known as Still disease; SD) delay diagnosis and appropriate treatment. The goal of this study was to identify features and mechanisms that distinguish SD from other systemic autoinflammatory ...
Yvonne M. Mueller, Charlotte Girard, Harmen J. G. van de Werken, Stefan J. Erkeland, Dwin G. B. Grashof, Laurie Vaillant, Renske J. H. den Dekker, Iris van Zuijen, Sharon Veenbergen, Fanny Coffin, Eric Bindels, Yvan Jamilloux, Katerina Laskari, Vassili Soumelis, Bruno Fautrel, Cem Gabay, Peter D. Katsikis   +16 more
wiley   +1 more source

Exercise‐specific plasma proteomic signatures in racehorses: Candidates for training adaptation and peak load monitoring

Equine Veterinary Journal, EarlyView.
Abstract Background Racehorses undergo profound physiological changes with training and competition, but current biomarkers inadequately capture the complex molecular dynamics of exercise. This study aimed to identify novel plasma biomarkers of training adaptation and peak load using high‐throughput proteomics.
Jowita Grzędzicka, Bianka Świderska, Ewa Sitkiewicz, Izabela Dąbrowska, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

The axis of complement C1 and nucleolus in antinuclear autoimmunity

Frontiers in Immunology, 2023
Antinuclear autoantibodies (ANA) are heterogeneous self-reactive antibodies that target the chromatin network, the speckled, the nucleoli, and other nuclear regions.
Shan Wu, Shan Wu, Junjie Chen, Junjie Chen, Boon Heng Dennis Teo, Boon Heng Dennis Teo, Seng Yin Kelly Wee, Seng Yin Kelly Wee, Ming Hui Millie Wong, Ming Hui Millie Wong, Jianzhou Cui, Jinmiao Chen, Jinmiao Chen, Khai Pang Leong, Jinhua Lu, Jinhua Lu   +15 more
doaj   +1 more source

Benzalkonium Chloride in Eye Drops Causing Allergic Contact Dermatitis: A Case Series

Australasian Journal of Dermatology, EarlyView.
ABSTRACT We present three patients who developed allergic contact dermatitis (ACD) from benzalkonium chloride (BAK) in ophthalmic drops. BAK is a preservative commonly found in ophthalmic formulations and there is a rising trend of ACD to this allergen. The irritant and sensitising properties of BAK on the ocular mucosa will be discussed.
Arav Kannen, Penelope Harrison, Elizabeth Christou   +2 more
wiley   +1 more source