Results 51 to 60 of about 10,647 (207)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Hypo-osmotic stress induces the epithelial alarmin IL-33 in the colonic barrier of ulcerative colitis [PDF]

, 2022
Epithelial alarmins are gaining interest as therapeutic targets for chronic inflammation. The nuclear alarmin interleukin-33 (IL-33) is upregulated in the colonic mucosa of acute ulcerative colitis (UC) and may represent an early instigator of the ...
Gundersen, Mona Dixon, Johnsen, Kay-Martin, Haraldsen, Guttorm, Johnsen, Kay Martin, Florholmen, Jon, Larsen, Kenneth Bowitz, Goll, Rasmus   +6 more
core   +1 more source

Topically Delivered Treg‐Attracting Microparticle‐Hydrogel Composites Recruit Regulatory T Cells and Limit Cardiac Injury After Severe Ischemia

Advanced Healthcare Materials, EarlyView.
CCL22‐releasing PLGA microparticles (MP) suspended in topically applied hydrogels (HEART) establish a sustained chemokine gradient at the injured myocardium. HEART recruits CCR4+ regulatory T cells, reduces infarct size and graft fibrosis, and improves cardiac function.
Matthew A. Borrelli, Alexis T. Reese, Jordan J. P. Warunek, Betsy Ann Varghese, Canxing Lin, Jeffery J. Baust, Brenda McMahon, Steven R. Little, Hēth R. Turnquist   +8 more
wiley   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

The role of basophils in the late asthmatic response and the effect of alarmin cytokines on basophil pro-inflammatory activity

, 2015
There is emerging evidence that the alarmin cytokines, thymic stromal lymphopoietin (TSLP), interleukin (IL)-25 (IL-25), and IL-33 are critical mediators of T helper cell type-2 (Th2)-driven inflammation in allergic airway disease.
Salter, Brittany
core   +1 more source

Interleukin‐1α Mediates Pancreatic Fibroblast Activation, Regulates Immune Cell Recruitment and Fibrosis in Acute and Chronic Pancreatitis

Advanced Science, EarlyView.
During pancreatitis, IL‐1α is released from necrotic acinar cells. In response to IL‐1α, pancreatic fibroblasts release chemokines and cytokines that regulate the recruitment of immune cells to the damaged organ. Furthermore, IL‐1α primes fibroblasts, resulting in increased tissue fibrosis during chronic pancreatitis.
Hala Mazloum, Shenja Buchholz, Hanna Schifter, Sabine Ameling, Leif Steil, Ben Lewin Becker, Elke Hammer, Georg Homuth, Uwe Völker, Barbara M. Bröker, Lukas Zierke, Frank Ulrich Weiss, Juliane Glaubitz, Matthias Sendler   +13 more
wiley   +1 more source

Alarmin S100A8/S100A9 as a biomarker for molecular imaging of local inflammatory activity [PDF]

, 2014
Inflammation has a key role in the pathogenesis of various human diseases. The early detection, localization and monitoring of inflammation are crucial for tailoring individual therapies.
Hermann, Sven, Roebrock, Kirsten, Faust, Andreas, Zenker, Stefanie, Geyer, Christiane, Schaefers, Michael, Voeller, Tom, Roth, Johannes, Petersen, Beatrix, Eisenblaetter, Michel, Vogl, Thomas, Bremer, Christoph, van Lent, Peter, Hermann, S., Vogl, T., Schafers, M., Eisenblatter, M., Roth, J., Petersen, B., Lent, P.L. van, Zenker, S., Roebrock, K., Faust, A., Geyer, C., Voller, T., Bremer, C.   +25 more
core   +3 more sources

The Multitasking Potential of Alarmins and Atypical Chemokines

Frontiers in Medicine, 2019
When the human genome was sequenced, it came as a surprise that it contains “only” 21,306 protein-coding genes. However, complexity and diversity are multiplied by alternative splicing, non-protein-coding transcripts, or post-translational modifications (
Aphrodite Kapurniotu, Ozgun Gokce, Jürgen Bernhagen, Jürgen Bernhagen, Jürgen Bernhagen   +4 more
doaj   +1 more source

Neuroinflammatory Biomarkers for Traumatic Brain Injury Diagnosis and Prognosis: A TRACK-TBI Pilot Study

Neurotrauma Reports, 2023
The relationship between systemic inflammation and secondary injury in traumatic brain injury (TBI) is complex. We investigated associations between inflammatory markers and clinical confirmation of TBI diagnosis and prognosis.
John K. Yue, Firas H. Kobeissy, Sonia Jain, Xiaoying Sun, Ryan R.L. Phelps, Frederick K. Korley, Raquel C. Gardner, Adam R. Ferguson, J. Russell Huie, Andrea L.C. Schneider, Zhihui Yang, Haiyan Xu, Cillian E. Lynch, Hansen Deng, Miri Rabinowitz, Mary J. Vassar, Sabrina R. Taylor, Pratik Mukherjee, Esther L. Yuh, Amy J. Markowitz, Ava M. Puccio, David O. Okonkwo, Ramon Diaz-Arrastia, Geoffrey T. Manley, Kevin K.W. Wang, Collaboration group, Collaboration group, Neeraj Badjatia, Brandon Foreman, Shankar Gopinath, Ramesh Grandhi, Ruchira M. Jha, Hester F. Lingsma, Christopher Madden, Debbie Y. Madhok, Michael A. McCrea, Randall Merchant, Lindsay D. Nelson, Laura B. Ngwenya, Claudia S. Robertson, Richard B. Rodgers, Gabriela G. Satris, David M. Schnyer, Alex B. Valadka, Thomas A. van Essen, Ross Zafonte   +45 more
doaj   +1 more source

Neuronal alarmin IL-1α evokes astrocyte-mediated protective signals: Effectiveness in chemotherapy-induced neuropathic pain [PDF]

, 2022
The distinction between glial painful and protective pathways is unclear and the possibility to finely modulate the system is lacking. Focusing on painful neuropathies, we studied the role of interleukin 1α (IL-1α), an alarmin belonging to the larger ...
Ghelardini C, Cervetto C, Lucarini E, Di Cesare Mannelli L, Toti A, Marcoli M, Parisio C, Micheli L, Laura Micheli, Lucarini, Elena, Chiara Cervetto, Manuela Marcoli, Alessandra Toti, Carla Ghelardini, Elena Lucarini, Di Cesare Mannelli, Lorenzo, Parisio, Carmen, Micheli, Laura, Carmen Parisio, Ghelardini, Carla, Lorenzo Di Cesare Mannelli, Toti, Alessandra   +21 more
core   +1 more source