Results 71 to 80 of about 10,647 (207)
Assessing the Mucosal Inflammatory Endotype of Obesity in Chronic Rhinosinusitis
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Background Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory syndrome of the paranasal sinuses that is defined phenotypically as either with nasal polyps (CRSwNP) or without nasal polyps (CRSsNP). More recently, inflammatory markers have been used to cluster patients into putative endotypes that are presumed to have a common ...
Jeffanie W. Gayoso +9 more
wiley +1 more source
Early Synovial Regulatory T Cell Engagement in Posttraumatic Osteoarthritis
Arthritis &Rheumatology, EarlyView.Objective Posttraumatic osteoarthritis (PTOA) develops despite restoration of joint biomechanics, suggesting that early postinjury biologic processes within the synovium shape disease trajectories. We investigated whether synovial Treg cells are engaged during the early phase following joint injury and whether experimental enrichment of this ...
Xueyou Zhang +5 more
wiley +1 more source
Arthritis &Rheumatology, Accepted Article.Objective Systemic sclerosis (SSc) is a chronic autoimmune disorder characterized by immune dysregulation and fibrosis, with myeloid‐derived suppressor cells (MDSCs) emerging as important regulators of immune responses. However, the role of MDSCs in SSc‐associated fibrosis and their interactions with other immune cell populations remain poorly ...
Stefanie Weber +15 more
wiley +1 more source
Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation
, 2015 In response to infections and irritants, the respiratory epithelium releases the alarmin interleukin (IL)-33 to elicit a rapid immune response. However, little is known about the regulation of IL-33 following its release.
D. R. Higazi (7639901) +30 more
core +4 more sources
Cell death in the pathogenesis of immune-mediated diseases
Swiss Medical Weekly, 2011 Cell death is a ubiquitous process whose immunological consequences can influence the course of infectious, autoimmune and inflammatory diseases. While cell death has long been dichotomised in terms of apoptosis and necrosis, other forms of death ...
D Pisetsky
doaj +1 more source
Lipid droplet profiling during neutrophil differentiation by stimulated Raman scattering microscopy
Biotechnology Progress, EarlyView.Abstract Lipid droplets (LDs) are dynamic organelles that serve as metabolic hubs and emerging regulators of immune cell fate. Although LDs have been implicated in immune regulation, how LD metabolism is remodeled during neutrophil differentiation and how stage‐specific LD dynamics shape mature neutrophil function remain poorly defined.
Ting‐Jung Sung +5 more
wiley +1 more source
iMetaMed, EarlyView.This study delineated nasal‐plasma metabolic reprogramming in house dust mite‐allergic rhinitis (HDM‐AR) and subcutaneous immunotherapy (SCIT) response, showing compartment‐specific signatures dominated by nasal lipid‐redox and plasma nucleotide‐NAD+ axes and across the HC–HDM‐AR–SCIT response continuum, dual‑compartment metabolites exhibited ...
Bixing Fang +13 more
wiley +1 more source
Biologics in Chronic Obstructive Pulmonary Disease: Current Status and Future Prospects [PDF]
Tuberculosis and Respiratory DiseasesSignificant progress has been made in managing chronic obstructive pulmonary disease (COPD), yet substantial unmet needs persist due to the disease's heterogeneity and the diverse underlying inflammatory mechanisms.
Joon Young Choi
doaj +1 more source
Understanding Behçet’s Disease in the Context of Innate Immunity Activation
Frontiers in Immunology, 2020 Behçet´s disease (BD) is a heterogeneous condition consisting of idiopathic systemic vasculitis affecting large and small blood vessels of different types (i.e., arteries, veins, or capillaries).
Sandro F. Perazzio +2 more
doaj +1 more source
iMetaMed, EarlyView.Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is increasingly recognized as a systemic disorder rather than a purely local prostate disease. The diagram illustrates the transition from the traditional local prostate‐centered model to a multi‐axis systemic framework involving clinical heterogeneity, local prostatic inflammation, systemic ...
Kun Wang +10 more
wiley +1 more source