Results 81 to 90 of about 8,634 (215)

The role of basophils in the late asthmatic response and the effect of alarmin cytokines on basophil pro-inflammatory activity

, 2015
There is emerging evidence that the alarmin cytokines, thymic stromal lymphopoietin (TSLP), interleukin (IL)-25 (IL-25), and IL-33 are critical mediators of T helper cell type-2 (Th2)-driven inflammation in allergic airway disease.
Salter, Brittany
core  

Pro-fibrogenic role of alarmin HMGB1 in HIV-HBV co-infection [PDF]

, 2023
OBJECTIVE: Liver disease is accelerated in people living with HIV (PLWH) with hepatitis B (HBV) coinfection. We hypothesised that liver fibrosis in HIV-HBV is triggered by increased hepatocyte apoptosis, microbial translocation and/or HIV/HBV viral ...
Avihingsanon, Anchalee, Otano, Itziar, Singh, Kasha P, Chen, Antony, Lewin, Sharon R, Pallett, Laura J, Duriez, Marion, Fusai, Giuseppe, Singh, Harsimran, Pinzani, Massimo, Maini, Mala K, Rombouts, Krista, Crane, Megan   +12 more
core  

S100A8/A9-alarmin promotes local myeloid-derived suppressor cell activation restricting severe autoimmune arthritis

, 2023
Summary: Immune-suppressive effects of myeloid-derived suppressor cells (MDSCs) are well characterized during anti-tumor immunity. The complex mechanisms promoting MDSC development and their regulatory effects during autoimmune diseases are less ...
Meike von Wulffen, Stefanie Robeck, Veronika Luehrmann, Antonella Russo, Sven Hermann, Thomas Vogl, Karin Loser, Martijn van den Bosch, Dmitry I. Gabrilovich, Johannes Roth, Lena Fischer-Riepe, Peter van Lent   +11 more
core   +1 more source

Impact of Biologics on Oscillometry Defined Small Airway Dysfunction in Uncontrolled Asthma

Clinical &Experimental Allergy, EarlyView.
Forced oscillometry technique defined small airways dysfunction as a treatable trait in asthma. Monoclonal antibodies can improve small airways dysfunction, but their effects vary by mechanism of action. ABSTRACT Small airways dysfunction (SAD) is a recognised treatable trait within severe asthma, associated with worse symptom control and increased ...
Robert Greig, Philipp Suter, Rory Chan, Brian Lipworth   +3 more
wiley   +1 more source

DataSheet_1_Endogenous Interleukin-33 Acts as an Alarmin in Liver Ischemia-Reperfusion and Is Associated With Injury After Human Liver Transplantation.zip

, 2021
Ischemia and reperfusion injury is an early inflammatory process during liver transplantation that impacts on graft function and clinical outcomes. Interleukin (IL)-33 is a danger-associated molecular pattern involved in kidney ischemia/reperfusion ...
Jean-Marc Gombert (155474), Louise Barbier (11461558), Rémy Sindayigaya (11461561), Aurélie Robin (525137), Ephrem Salamé (11301767), Thierry Hauet (525141), Jean-Philippe Girard (376455), Antoine Thierry (525136), Fanny Dujardin (11461567), Luc Pellerin (75905), André Herbelin (177372), Héloïse Ducousso (11461564)   +11 more
core   +1 more source

Plasma Elastase Screening in Hematological Disease Reveals Its Potential as a Diagnostic and Prognostic Biomarker in Hematological Malignancies

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Neutrophil‐extracellular traps are net‐like material released by triggered neutrophils and composed of decondensed chromatin linked to nuclear proteins. Elastase, one of the fourth most represented neutrophil‐specific serine proteases stored in azurophil granules of naïve neutrophils, exerts various actions, including degradation ...
Pasqualina Scala, Anna Maria Della Corte, Angela Bertolini, Marisa Gorrese, Francesca Picone, Bianca Serio, Danilo De Novellis, Laura Mettivier, Luca Pezzullo, Maria Carmen Martorelli, Denise Morini, Matteo D'Addona, Bianca Cuffa, Carmine Selleri, Valentina Giudice   +14 more
wiley   +1 more source

OX40/OX40L modulation: A target for regulating T cells in cutaneous inflammatory disorders

Journal of the European Academy of Dermatology and Venereology, EarlyView.
OX40 and OX40L are a co‐stimulatory immune checkpoint pair. Modulation of this pair impacts multiple immune phenotypes and is an attractive target for immunotherapy in dermatological disorders. Trials are underway with the majority in atopic dermatitis and currently in phase 3 trials.
Aditya K. Gupta, Julia Steriopoulos, Vasiliki Economopoulos, Paradi Mirmirani, Vincent Piguet   +4 more
wiley   +1 more source

Das proinflammatorische Alarmin S100A8/S100A9 als objektiver Parameter zur Diagnostik eines Peritonsillarabszesses

, 2017
Einleitung: Es wurde untersucht, ob sich das proinflammatorische Alarmin S100A8/S100A9 im Speichel und Serum als objektiver Marker zur Identifizierung eines Peritonsillarabszesses eignet.Methoden: Von Patienten, die sich aufgrund einer akuten ...
Stenner, M, Rudack, C, Vogl, T, Spiekermann, CO, Roth, J   +4 more
core   +1 more source

Peri‐Implantitis and Periodontitis: Biological Convergence, Contextual Divergence

Journal of Periodontal Research, EarlyView.
Periodontal and peri‐implant tissues differ and coincide in many aspects, from the clinical and radiological perspective, including histology, microbiology, and molecular markers. Thus, health and disease may also follow different and similar routes.
Pablo Galindo‐Moreno, Pablo Galindo‐Fernandez, Allinson Olaechea, Francisco O'Valle, Abdusalam E. Alrmali, Hom‐Lay Wang, Miguel Padial‐Molina   +6 more
wiley   +1 more source

Granulysin activates antigen-presenting cells through TLR4 and acts as an immune alarmin

, 2010
Granulysin (GNLY), an antimicrobial protein present in the granules of human cytotoxic T lymphocytes and natural killer (NK) cells, is produced as an intact 15-kDa form that is cleaved to yield a 9-kDa form.
Carol Clayberger, Joost J. Oppenheim, Alan M. Krensky, Michael W. Finn, Gonzalo de la Rosa, Yana Li, Poonam Tewary, De Yang   +7 more
core   +1 more source