Results 81 to 90 of about 10,647 (207)
, 2016 Serum cytokine & alarmin concentrations (mean value ± SEM); NT-T (normothermic trauma), NT-S (normothermic sham), HT-T (hypothermic trauma), HT-S (hypothermic sham), statistical significance p = a) from sham, b) from baseline, c) NT-T vs. HT-T).
D. Eschbach (2657245) +11 more
core +1 more source
S100A8/A9 Drives Emergency Granulopoiesis to Promote Triple‐Negative Breast Cancer Metastasis
iNew Medicine, EarlyView.ABSTRACT Objective Triple‐negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by high metastatic potential and limited therapeutic options. Although neutrophils contribute to tumor progression, how tumors systemically regulate neutrophil production remains poorly understood.
Hami Hemati +5 more
wiley +1 more source
Journal of Associated Medical SciencesBackground: The epithelial alarmin Interleukin-33 (IL-33) and the immunomodulator vitamin D3 are implicated in asthma pathogenesis, yet their combined clinical utility and interplay in pediatric populations remain underexplored. Objectives: This study
Zahraa Hazim Aziz +1 more
doaj +1 more source
JPGN Reports, EarlyView.Abstract Tezepelumab is a human monoclonal antibody that binds to human thymic stromal lymphopoietin (TSLP), an epithelial cytokine that plays a role in Type 2 signaling. We describe a 17‐year‐old with a history of eosinophilic esophagitis (EoE) and eosinophilic gastroenteritis who demonstrated response to tezepelumab with both clinical and histologic ...
Destiny Newsome +3 more
wiley +1 more source
Trisomy 8 defines a distinct subtype of myeloproliferative neoplasms driven by the MYC-alarmin axis
Despite advances in understanding the genetic abnormalities in myeloproliferative neoplasms (MPNs) and the development of JAK2 inhibitors, there is an urgent need to devise new treatment strategies, particularly for triple negative myelofibrosis (MF ...
Su, Siyuan +25 more
core +1 more source
JEADV Clinical Practice, EarlyView.Skin samples of Hailey‐Hailey and Darier diseases were analyzed for inflammatory and barrier markers using indirect immunofluorescence and transcriptomic techniques. A mixed Th2/Th17 inflammatory pattern and altered expression of barrier markers were observed.
Ella Glodjajic +10 more
wiley +1 more source
Allergy, EarlyView.ABSTRACT Allergic diseases arise from aberrant immune recognition of otherwise harmless environmental proteins and are driven by epitope‐specific interactions between allergens and the adaptive immune system. Although component‐resolved diagnostics have improved molecular characterisation of sensitization, they remain limited to whole‐allergen ...
Mark Møiniche +11 more
wiley +1 more source
Ubiquitination of
mBio, 2019 Listeria monocytogenes is a pathogenic bacterium causing potentially fatal foodborne infections in humans and animals. While the mechanisms used by Listeria to manipulate its host have been thoroughly characterized, how the host controls bacterial ...
Edith Gouin +10 more
doaj +1 more source
Serotonin Degradation and Lipid Metabolism Regulate Human Tc2 Cell Effector Functions
Allergy, EarlyView.Human Tc2 cells exhibit a metabolically active phenotype characterized by enhanced glycolysis, mitochondrial respiration, and fatty acid uptake dependent on PPARγ. Alarmins strongly amplify IL‐5 and IL‐13 production in Tc2 cells, supporting a shared immunometabolic program across type 2 lymphocytes.
Sabrina de Souza Ferreira +13 more
wiley +1 more source
High Mobility Group Box Protein-1 in Wound Repair
Cells, 2012 High-mobility group box 1 protein (HMGB1), a member of highly conserved non-histone DNA binding protein family, has been studied as transcription factor and growth factor.
Mauro Patrone +3 more
doaj +1 more source