Results 101 to 110 of about 8,634 (215)

Interleukin‐5, Eosinophils, and Interleukin‐5 Pathway Inhibitors in Eosinophilic Granulomatosis With Polyangiitis

open access: yesArthritis &Rheumatology, Volume 78, Issue 6, Page 1196-1205, June 2026.
Interlukin‐5 (IL‐5) plays a crucial role in the pathogenesis of eosinophilic granulomatosis with polyangiitis (EGPA) by promoting eosinophil differentiation, activation, and survival. We present here a typical case of EGPA in which treatment with IL‐5 pathway inhibitors is prescribed, showing to be beneficial for the patient.
Alvise Berti, Christian Pagnoux
wiley   +1 more source

Integrative Single‐Cell RNA Sequencing and Spatial Transcriptomics Uncover Distinct Fibroblast–Macrophage Crosstalk in Human Hip Synovium Between Patients With Femoroacetabular Impingement and Osteoarthritis

open access: yesArthritis &Rheumatology, Volume 78, Issue 6, Page 1219-1230, June 2026.
Objective Femoroacetabular impingement (FAI) and synovitis have been recognized as essential factors for developing osteoarthritis (OA) in the hip joints. However, little is known about altered synovial cellular compositions, their associated transcriptomic profiles, and cell–cell interactions in FAI and hip OA.
Gulzada Kulzhanova   +9 more
wiley   +1 more source

Programmed Cell Death in Chronic Rhinosinusitis

open access: yesClinical and Translational Allergy, Volume 16, Issue 6, June 2026.
ABSTRACT Chronic rhinosinusitis (CRS) is a prevalent upper respiratory condition characterized by a multifaceted etiology involving various cellular and molecular processes. In recent years, researchers have increasingly recognized the significance of different forms of programmed cell death (PCD), such as apoptosis and pyroptosis, in the pathological ...
Xingchen Liu   +5 more
wiley   +1 more source

Skin Tape Stripping: A Non‐Invasive Approach Linking Epidermal Changes and Systemic Inflammation in Atopic Dermatitis

open access: yesClinical and Translational Allergy, Volume 16, Issue 6, June 2026.
This review positions skin tape stripping as a methodological bridge in atopic dermatitis, linking epidermal molecular profiling with systemic inflammation. Integrated with multi‐omics technologies, STS enables non‐invasive biomarker discovery, disease endotyping, and treatment monitoring, advancing precision medicine for AD. ABSTRACT Atopic dermatitis
Ziyuan Tian, Ke Xue, Yong Cui
wiley   +1 more source

Improvement of Mixed Inflammatory Environment in Nasal Secretions of Diffuse Type 2 Chronic Rhinosinusitis With Nasal Polyps Under Dupilumab

open access: yesClinical and Translational Allergy, Volume 16, Issue 6, June 2026.
ABSTRACT Background In Western countries, Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) is predominantly associated with a type 2 inflammatory endotype. While nasal secretion analysis shows promise for disease endotyping, current biomarkers remain limited for accurate stratification, disease monitoring, and prediction of treatment response ...
Fabio S. Ryser   +4 more
wiley   +1 more source

The Glia-Derived Alarmin IL-33 Orchestrates the Immune Response and Promotes Recovery following CNS Injury

open access: yes, 2015
SummaryInflammation is a prominent feature of CNS injury that heavily influences neuronal survival, yet the signals that initiate and control it remain poorly understood.
Kipnis, Jonathan   +4 more
core   +1 more source

Alarmins and More [PDF]

open access: yesClinical Therapeutics, 2016
openaire   +2 more sources

Tocilizumab and Dexamethasone Reduce TNF‐α and IL‐33 and Oxidative Stress in Kidney Tissue in Oleic Acid‐Induced ARDS Model

open access: yesJournal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.
Oleic acid causes ARDS‐associated AKI. Tocilizumab and dexamethasone reduces ARDS‐induced kidney injury. The width of the filtration slits increases in kidney injury. Tocilizumab and dexamethasone suppress TNF‐a and IL‐33. ABSTRACT The most common extrapulmonary organ injury in cases of acute respiratory distress syndrome (ARDS) is acute kidney injury (
Huseyin Serkan Erol   +4 more
wiley   +1 more source

Novel Therapeutics for Chronic Obstructive Pulmonary Disease: From Empirical Bronchodilation to Precision Medicine

open access: yesRespirology, Volume 31, Issue 6, Page 561-577, June 2026.
ABSTRACT Chronic obstructive pulmonary disease (COPD) remains the third leading cause of death worldwide, and conventional bronchodilator‐based therapies have limited efficacy in preventing exacerbations and disease progression. The 2024–2026 period represents a historic inflection point: three mechanistically distinct agents received Food and Drug ...
Naoya Fujino, Hisatoshi Sugiura
wiley   +1 more source

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