Results 111 to 120 of about 10,647 (207)

Alerting stem cells to regenerate

, 2018
Alarmin delivery accelerates tissue regeneration by transitioning quiescent stem cells to the metabolically active G Alert state.
Julianne L. Holloway
core   +1 more source

Reactive Astrocyte‐Associated IL‐33 Signaling Contributes to a Protective Neuroimmune State During Chronic Toxoplasma gondii–Plasmodium berghei Coinfection

Glia, Volume 75, Issue 1, January 2027.
Chronic Toxoplasma gondii infection establishes a regulated neuroimmune environment that protects against experimental cerebral malaria without reducing cerebral parasite burden. Coinfection is associated with the emergence of reactive astrocytes displaying an intermediate inflammatory phenotype characterized by the co‐expression of CXCL‐10 and TGF‐β ...
Inès Leleu, Tarun Keswani, Fabien Herbert, Capucine Picavet, Manon Arnaud, Sabrina Marion, Corine Glineur, Sylviane Pied   +7 more
wiley   +1 more source

TSLP: contrasting roles in cancer

Frontiers in Immunology
Thymic stromal lymphopoietin (TSLP) is an alarmin cytokine possessing a plethora of pleiotropic properties. Human and mouse TSLP exerts their activity via a heterodimeric complex composed of TSLP receptor (TSLPR) chain and IL-7Rα.
Remo Poto, Remo Poto, Remo Poto, Gianni Marone, Gianni Marone, Gianni Marone, Steven F. Ziegler, Steven F. Ziegler, Steven F. Ziegler, Gilda Varricchi, Gilda Varricchi, Gilda Varricchi   +11 more
doaj   +1 more source

Established Tissue Eosinophilia is Not Synonymous With Ongoing Local Type 2 Cytokine Activity

Allergy, EarlyView.
Franziska U. Nordström, Malin Lindstedt, Lennart Greiff, Jonas S. Erjefält   +3 more
wiley   +1 more source

Pyroptosis in Preeclampsia: Placenta‐to‐Maternal Organ Communication, Molecular Mechanisms, and Therapeutic Targets

Comprehensive Physiology, Volume 16, Issue 6, December 2026.
Schematic diagram illustrating the potential mechanisms and core molecules contributing to the development of PE via mediating pyroptosis: focus on trophoblasts and endothelial cells. Pyroptosis of trophoblast cells in the placenta of preeclampsia not only inhibits its invasion, migration, and differentiation, causing local infiltration and ...
Xianyi Zhou, Liming Yuan, Ya Li, Rong Zhou, Linbo Gao, Xiaohong Wei   +5 more
wiley   +1 more source

Multi‐Organ Inflammatory and Endocrine Crosstalk Shapes the Early Brain Response to Combined Burn and Blast Injury

The FASEB Journal, Volume 40, Issue 21, 15 November 2026.
Concomitant burn injury and blast‐induced mild TBI lead to a magnified neuroimmune response shaped by endocrine stress‐related pathways and IL‐1R1‐dependent inflammatory signals, which also produce cytokine‐mediated impairment of erythropoiesis. These integrated systemic and CNS responses illustrate how inflammation, hematopoietic adaptation, and early
Hana C. Schwierling, Satarupa Sengupta, John G. Noel, Christopher J. O'Connell, Andrew S. Potter, Mike Adam, Matthew J. Robson, Jason C. Gardner   +7 more
wiley   +1 more source

Potential Therapeutic Aspects of Alarmin Cytokine Interleukin 33 or Its Inhibitors in Various Diseases

, 2016
International audiencePurpose The purpose of this review was to examine the comprehensively accumulated data regarding potential therapeutic aspects of exogenous administration of interleukin 33 (IL-33) or its antagonists in allergic, cancerous ...
Piquet-Pellorce, Claire, Ahmad Khan, Hilal, Imran Arshad, Muhammad, Noel, Gregory, Samson, Michel   +4 more
core   +1 more source

Regulation of IL‐13 Signaling by Retinoic Acid in Airway Epithelial Cells

The FASEB Journal, Volume 40, Issue 21, 15 November 2026.
Our proteomics and subsequent biochemical analyses reveal the effects of retinoic acid receptor (RAR) agonists, ATRA (pan‐RAR agonist), or CD1530 (RARγ agonist) in counteracting molecular changes induced by IL‐13 relevant to airway inflammation and remodeling, such as proteins involved in epithelial‐to‐mesenchymal transition (EMT) and extracellular ...
Vanshika Patel, Jianshi Yu, Mehari Weldemariam, Paul Shapiro, Deepak A. Deshpande, Maureen A. Kane   +5 more
wiley   +1 more source

Epithelial-derived cytokines in the pathogenesis of severe asthma

Frontiers in Allergy
IntroductionAirway epithelial cells function as the first physical barrier against pathogens and are key regulators of immune responses by producing a wide array of cytokines involved in both innate and adaptive immunity.MethodsThis review summarizes ...
Duong Duc Pham, Tae-Bum Kim
doaj   +1 more source

Plasma Level of Soluble ST2 in Chronically Infected HIV-1 Patients with Suppressed Viremia

, 2017
International audienceINTRODUCTION : Interleukin-33 (IL-33) is a cell damage-induced alarmin. The plasma concentration of suppression of tumorogenicity (sST2), a surrogate marker of IL-33 production, is a prognostic marker of cardiovascular disease ...
Younas, Mehwish, Vikram Mehraj, Pierre Corbeau, Jacques Reynes, Cezar, Renaud, Psomas, Christina, Jean-Pierre Routy, Mehraj, Vikram, Edouard Tuaillon, Renaud Cezar, Tuaillon, Edouard, Guigues, Adeline, Routy, Jean-Pierre, Portales, Pierre, Corbeau, Pierre, Mehwish Younas, Christina Psomas, Adeline Guigues, Reynes, Jacques, Pierre Portales   +19 more
core   +1 more source